US3965260A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-inflammatory dipeptide
Assignee: Individual
•
Filing: 1975-07-07
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Granted: 1976-06-22
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Expires: 1995-07-07
Abstract
Abstract The pharmaceutical composition has a dipeptide or a pharmaceutically-acceptable salt thereof as an active ingredient. The depeptide has the general formula ##EQU1## wherein R 1 and R 2 are the same or different and each is either phenyl or indolyl. administration composition may be in a solid form for oral administraion in which case the active ingredient is surrounded by an enteric coating. The composition may also be in a liquid form for administration by injection in which case the active ingredient is dissolved in a physiologically compatible sterile liquid. The composition is useful in the treatment of inflammation in mammals and may be administered daily in an amount of about 40mg of the dipeptide or salt per kilogram weight of the mammal.
Inventors
- 👤 John N. McArthur
- 👤 Peter D. Dawkins
- 👤 Mervyn J. H. Smith
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 05:25
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06139; C07K5/06156; C07K5/06008; C07K5/06078
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
74 words
A method for the treatment of inflammation in a mammal which comprises administering to such mammal an effective amount of a composition comprising: a dipeptide or a pharmaceutically-acceptable salt thereof surrounded by a coating of an enteric substance which resists dissolution in gastric fluids but disintegrates in the intestine, said dipeptide having the general formula: ##EQU4## wherein R 1 and R 2 are the same or different and each is either phenyl or indolyl.
Claim 2
Independent Claim
74 words
A method for the treatment of inflammation in a mammal which comprises administering to such mammal an effective amount of a composition comprising: a dipeptide or a pharmaceutically-acceptable salt thereof surrounded by a coating of an enteric substance which resists dissolution in gastric fluids but disintegrates in the intestine, said dipeptide having the general formula: ##EQU4## wherein R 1 and R 2 are the same or different and each is either phenyl or indolyl.
Claim 3
Independent Claim
62 words
A method for the treatment of inflammation in a mammal which comprises administering to such mammal an effective D-phenylalanyl-D-tryptophan, of a composition comprising: a dipeptide or a pharmaceutically-acceptable salt thereof dissolved in a physiologically compatible sterile liquid, said dipeptide having the general formula: ##EQU5## wherein R 1 and R 2 are the same or different and each is either phenyl or indolyl.
Claim 4
Independent Claim
62 words
A method for the treatment of inflammation in a mammal which comprises administering to such mammal an effective D-phenylalanyl-D-tryptophan, of a composition comprising: a dipeptide or a pharmaceutically-acceptable salt thereof dissolved in a physiologically compatible sterile liquid, said dipeptide having the general formula: ##EQU5## wherein R 1 and R 2 are the same or different and each is either phenyl or indolyl.
Claim 5
Dependent Claim
35 words
A method as claimed in claim 1 wherein the daily dose of said composition administered to said mammal is about 40 mg of said dipeptide or pharmaceutically-acceptable salt thereof per kilogram weight of said mammal.
Claim 6
Dependent Claim
35 words
A method as claimed in claim 2 wherein the daily dose of said composition administered to said mammal is about 40 mg of said dipeptide or pharmaceutically-acceptable salt thereof per kilogram weight of said mammal.
Claim 7
Dependent Claim
26 words
A method as claimed in claim 1 wherein said dipeptide is selected from the group consisting of: D-phenylalanyl-D-phenylalanine, D-phenylalanyl-D-tryptophan, D-tryptophany-D-phenylalanine, D-tryptophanyl-D-tryptophan and L-tryptophanyl-L-tryptophan and mixtures thereof.
Claim 8
Dependent Claim
28 words
A method as claimed in claim 2 wherein said dipeptide is selected from the group consisting of: D-phenylalanyl-D-phenylalanine, D-p henylalanyl-D-tryptophan, D-tryptophanyl-D-phenylalanine, D-tryptophanyl-D-tryptophan and L-tryptophanyl-L-tryptophan, L-tryptophanyl-D-tryptophan and mixtures thereof.
Claim 9
Dependent Claim
77 words
A pharmaceutical composition useful in the treatment of inflammation which comprises: a dipeptide or a pharmaceutically-acceptable salt thereof surrounded by a coating of an enteric substance which resists dissolution in gastric fluids but disintegrates in the intestine, the amount of said dipeptide present in said composition being an amount effective against inflammation, said dipeptide having the general formula: ##EQU6## wherein R 1 and R 2 are the same or different and each is either phenyl or indolyl.
Claim 10
Dependent Claim
77 words
A pharmaceutical composition useful in the treatment of inflammation which comprises: a dipeptide or a pharmaceutically-acceptable salt thereof surrounded by a coating of an enteric substance which resists dissolution in gastric fluids but disintegrates in the intestine, the amount of said dipeptide present in said composition being an amount effective against inflammation, said dipeptide having the general formula: ##EQU6## wherein R 1 and R 2 are the same or different and each is either phenyl or indolyl.
Claim 11
Dependent Claim
17 words
The composition as claimed in claim 7 wherein said enteric coating is shellac or cellulose acetate phthalate.
Claim 12
Dependent Claim
21 words
The composition of claim 7 wherein said dipeptide is selected from the group consisting of: D-phenylalanyl-D-phenylalanine, D-phenylalanyl-D-tryptophan, D-tryptophanyl-D-phenylalanine, D-tryptophanyl-D-tryptophan, and L-tryptophanyl-L-tryptophan.
Claim 13
Dependent Claim
65 words
A pharmaceutical composition useful in the treatment of inflammation which comprises: a dipeptide or a pharmaceutically-acceptable salt thereof dissolved in a physiologically compatible sterile liquid, the amount of said dipeptide present in said composition being an amount effective against inflammation, said dipeptide having the general formula: ##EQU7## wherein R 1 and R 2 are the same or different and each is either phenyl or indolyl.
Claim 14
Dependent Claim
65 words
A pharmaceutical composition useful in the treatment of inflammation which comprises: a dipeptide or a pharmaceutically-acceptable salt thereof dissolved in a physiologically compatible sterile liquid, the amount of said dipeptide present in said composition being an amount effective against inflammation, said dipeptide having the general formula: ##EQU7## wherein R 1 and R 2 are the same or different and each is either phenyl or indolyl.
Claim 15
Dependent Claim
23 words
The composition of claim 10 wherein said dipeptide is selected from the group consisting of: D-phenylalanyl-D-phenylalanine, D-phenylalanyl-D-tryptophan, D-tryptophanyl-D-phenylalanine, D-tryptophanyl-D-tryptophan, L-tryptophanyl-L-tryptophan and mixtures thereof.
Claim 16
Dependent Claim
39 words
The composition of claim 10 wherein said sterile liquid is water to which is added a base to cause dissolution of said active ingredient and afterward to which is added an acid to decrease the pH to about 7.2.
Claim 17
Dependent Claim
17 words
The composition of claim 12 wherein said base is sodium hydroxide and said acid is hydrochloric acid.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-22 | 1979-12-22 | 1980-06-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-22 | 1983-12-22 | 1984-06-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-22 | 1987-12-22 | 1988-06-22 | $7700.00 | Window Closed / Lapsed |