US3963732A
Expired / Lapsed
US
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Process for preparing dihydroxydiphenylmethane derivatives
Assignee: Individual
•
Filing: 1974-08-21
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Granted: 1976-06-15
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Expires: 1994-08-21
Abstract
Abstract There is provided a new process for the preparation of esters of 4,4'-dihydroxydiphenyl-(2-pyridyl)-methane of the general formula: ##SPC1## which Wherein R 1 is a hydrogen atom or a sulpho group or an acyl radical and R 2 is a hydrogen atom or a carboalkoxy radical, and the salts thereof with pharmaceutically-acceptable, non-toxic inorganic and organic bases. Those compounds in wich R 2 is a carboalkoxy radical are new.
Inventors
- 👤 Tiberio Bruzzese
- 👤 Rodolfo Ferrari
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 00:39
CPC Classifications
C; C09; C09B; C09B11/00; C09B11/04; C09B11/26
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
114 words
A process for the preparation of an ester of the formula ##SPC6## in which R 1 is a hydrogen atom or a suphoxy group or is alkanoyl having up to 6 carbon atoms and Me is a pharmaceutically acceptable inorganic or organic non-toxic cation, wherein a compound of the formula ##SPC7## in which Me and R 1 have the same meaning as above, is selectively hydrolyzed and then decarboxylated, in a basic medium to produce the objective compound I wherein R 1 is hydrogen or a sulphoxy group and, when desired, acylating said compound with an organic acid to produce a compound I wherein R 1 is alkanoyl having up to 6 carbon atoms.
Claim 2
Dependent Claim
114 words
A process for the preparation of an ester of the formula ##SPC6## in which R 1 is a hydrogen atom or a suphoxy group or is alkanoyl having up to 6 carbon atoms and Me is a pharmaceutically acceptable inorganic or organic non-toxic cation, wherein a compound of the formula ##SPC7## in which Me and R 1 have the same meaning as above, is selectively hydrolyzed and then decarboxylated, in a basic medium to produce the objective compound I wherein R 1 is hydrogen or a sulphoxy group and, when desired, acylating said compound with an organic acid to produce a compound I wherein R 1 is alkanoyl having up to 6 carbon atoms.
Claim 3
Dependent Claim
22 words
A process according to claim 1 wherein R 1 is alkanoyl having up to 6 carbon atoms having up to 6 carbons.
Claim 4
Dependent Claim
18 words
A process according to claim 1 wherein the hydrolysis and decarboxylation takes place in an aqueous basic medium.
Claim 5
Dependent Claim
33 words
A process according to claim 1 wherein the compound II is subjected to a selective hydrolysis and decarboxylation reaction in a boiling dilute aqueous sodium hydroxide solution for a period of 1 hour.
Claim 6
Dependent Claim
19 words
A process according to claim 4 wherein the dilute aqueous solution hydroxide solution contains 3% of sodium hydroxide therein.
Claim 7
Dependent Claim
35 words
A process according to claim 1 wherein the compound II is subjected to a selective hydrolysis and decarboxylation reaction in a solution of potassium tert.-butylate in dimethylsulphoxide at 100°C for a period of 1 hour.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-15 | 1979-12-15 | 1980-06-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-15 | 1983-12-15 | 1984-06-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-15 | 1987-12-15 | 1988-06-15 | $7700.00 | Window Closed / Lapsed |