US3962429A
Expired / Lapsed
US
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Method for reducing side effects of aminoglycoside antibiotics and composition therefor
Assignee: Chugai Pharmaceutical Co Ltd
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Filing: 1974-07-23
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Granted: 1976-06-08
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Expires: 1994-07-23
Abstract
Abstract Side effects of an aminoglycoside antibiotic, renal toxicity and 8th nerve toxicity, are reduced by administering a glucosaccharic acid as well as the aminoglycoside antibiotic. An improved method for treating bacterial infection using an aminoglycoside antibiotic and a pharmaceutical composition of an aminoglycoside antibiotic with reduced side effects are disclosed.
Inventors
- 👤 Kouji Furuno
- 👤 Akira Okazaki
- 👤 Syuzo Matsubara
- 👤 Motoharu Shiba
- 👤 Akitoshi Shioya
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 01:17
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K47/00; A61K47/06; A61K47/26
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
122 words
A method for treating bacterial infection and reducing the side effects of such treatment, comprising administering to mammals, in an amount sufficient to treat bacterial infection, both glucosaccharo-1,4-lactone, glucosaccharo-6,3-lactone, or the sodium, potassium or calcium salt of one of said lactones, and an aminoglycoside antibiotic selected from the group consisting of streptomycin, neomycin B and C, kanamycin A, B and C, ribostamycin, paromomycin I and II, a gentamicin complex, tobramycin, butirosin A and B, lividomycin A and B, 3', 4'-dideoxy-kanamycin B, sismomicin, 1-N-{(S)-4-amino-2-hydroxybutylyl}-3',4'-dideoxy-kanamycin B, 1-N-{(S)-4-amino-2-hydroxybutylyl}-3',4'-dideoxyneamine, 1-N-{(S)-4-amino-2-hydroxybutylyl} kanamycin A and mineral acid addition salts thereof, wherein said lactone or salt is used in an amount of from 50-1000% by weight of the antibiotic used based on the free form of the amino-glycoside antibiotic.
Claim 2
Independent Claim
122 words
A method for treating bacterial infection and reducing the side effects of such treatment, comprising administering to mammals, in an amount sufficient to treat bacterial infection, both glucosaccharo-1,4-lactone, glucosaccharo-6,3-lactone, or the sodium, potassium or calcium salt of one of said lactones, and an aminoglycoside antibiotic selected from the group consisting of streptomycin, neomycin B and C, kanamycin A, B and C, ribostamycin, paromomycin I and II, a gentamicin complex, tobramycin, butirosin A and B, lividomycin A and B, 3', 4'-dideoxy-kanamycin B, sismomicin, 1-N-{(S)-4-amino-2-hydroxybutylyl}-3',4'-dideoxy-kanamycin B, 1-N-{(S)-4-amino-2-hydroxybutylyl}-3',4'-dideoxyneamine, 1-N-{(S)-4-amino-2-hydroxybutylyl} kanamycin A and mineral acid addition salts thereof, wherein said lactone or salt is used in an amount of from 50-1000% by weight of the antibiotic used based on the free form of the amino-glycoside antibiotic.
Claim 3
Dependent Claim
27 words
The method for treating bacterial infection in accordance with claim 1, wherein said mineral acid addition salts are sulfuric acid addition salts or hydrochloric acid addition salts.
Claim 4
Dependent Claim
14 words
A method in accordance with claim 1, wherein said aminoglycoside antibiotic is gentamicin complex.
Claim 5
Dependent Claim
27 words
A method in accordance with claim 1 wherein said aminoglycoside antibiotic and said lactone or salt are administered in the form of a mixture by intramuscular injection.
Claim 6
Dependent Claim
14 words
A method in accordance with claim 4, wherein said aminoglycoside antibiotic is gentamicin complex.
Claim 7
Dependent Claim
23 words
A method in accordance with claim 1 wherein said aminoglycoside antibiotic is administered through a different administration route than said lactone or salt.
Claim 8
Dependent Claim
27 words
The method for treating bacterial infection in accordance with claim 6, wherein the mineral acid addition salts are sulfuric acid addition salts or hydrochochloric acid addition salts.
Claim 9
Dependent Claim
14 words
A method in accordance with claim 6, wherein said aminoglycoside antibiotic is gentamicin complex.
Claim 10
Dependent Claim
35 words
The method for treating bacterial infection in accordance with claim 6, wherein said aminoglycoside antibiotic is administered by intramuscular injection in the form of an aqueous solution and said lactone or salt is orally administered.
Claim 11
Dependent Claim
14 words
A method in accordance with claim 9 wherein said aminoglycoside antibiotic is gentamicin complex.
Claim 12
Dependent Claim
103 words
A pharmaceutical composition for treating bacterial infection and reducing the side effects of such treatment, comprising an aminoglycoside antibiotic selected from the group consisting of streptomycin, neomycin B and C, kanamycin A, B and C, ribostamycin, paromomycin I and II, gentamicin complex, tobramycin, butirosin A and B, lividomycin A and B, 3'4'-dideoxy-kanamycin B, sismomicin, 1-N-{(S)-4-amino-2-hydroxybutylyl}-3',4'-dideoxy-kanamycin B, 1-N-{(S)-4-amino-2-hydroxybutylyl}-3',4',-dideoxyneamine, 1-N-{(S)-4-amino-2-hydroxybutylyl} kanamycin A and mineral acid addition salts thereof, having compounded thereinto glucosaccharo-1,4-lactone, glucosaccharo-6,3-lactone or a sodium, potassium or calcium salt of one of said lactones, in an amount of from 50-1000% by weight of the antibiotic present based on the free form of the antibiotic.
Claim 13
Dependent Claim
103 words
A pharmaceutical composition for treating bacterial infection and reducing the side effects of such treatment, comprising an aminoglycoside antibiotic selected from the group consisting of streptomycin, neomycin B and C, kanamycin A, B and C, ribostamycin, paromomycin I and II, gentamicin complex, tobramycin, butirosin A and B, lividomycin A and B, 3'4'-dideoxy-kanamycin B, sismomicin, 1-N-{(S)-4-amino-2-hydroxybutylyl}-3',4'-dideoxy-kanamycin B, 1-N-{(S)-4-amino-2-hydroxybutylyl}-3',4',-dideoxyneamine, 1-N-{(S)-4-amino-2-hydroxybutylyl} kanamycin A and mineral acid addition salts thereof, having compounded thereinto glucosaccharo-1,4-lactone, glucosaccharo-6,3-lactone or a sodium, potassium or calcium salt of one of said lactones, in an amount of from 50-1000% by weight of the antibiotic present based on the free form of the antibiotic.
Claim 14
Dependent Claim
24 words
The pharmaceutical composition in accordance with claim 11, wherein said mineral acid addition salts are sulfuric acid addition salts or hydrochloric acid addition salts.
Claim 15
Dependent Claim
15 words
The pharmaceutical composition in accordance with claim 11, wherein said aminoglycoside antibiotic is gentamicin complex.
Claim 16
Dependent Claim
22 words
The pharmaceutical composition in accordance with claim 11, wherein said aminoglycoside antibiotic is partially reacted with said lactone to form a salt.
Claim 17
Dependent Claim
14 words
The composition in accordance with claim 14, wherein said aminoglycoside antibiotic is gentamicin complex.
Claim 18
Dependent Claim
13 words
The pharmaceutical composition in accordance with claim 11, wherein said composition is freeze-dried.
Claim 19
Dependent Claim
14 words
The composition in accordance with claim 16, wherein said aminoglycoside antibiotic is gentamicin complex.
Claim 20
Dependent Claim
20 words
The pharmaceutical composition in accordance with claim 11, wherein said composition is in the form of a parenteral aqueous solution.
Claim 21
Dependent Claim
14 words
The composition in accordance with claim 18, wherein said aminoglycoside antibiotic is gentamicin complex.
Claim 22
Dependent Claim
18 words
The pharmaceutical composition in accordance with claim 11, wherein said composition is in the form of parenteral powder.
Claim 23
Dependent Claim
14 words
The composition in accordance with claim 20, wherein said aminoglycoside antibiotic is gentamicin complex.
Claim 24
Dependent Claim
23 words
The pharmaceutical composition in accordance with claim 11, further including a stabilizing amount of methionine as a stabilizer for the lactone or salt.
Claim 25
Dependent Claim
14 words
The composition in accordance with claim 22, wherein said aminoglycoside antibiotic is gentamicin complex.
Claim 26
Dependent Claim
39 words
The pharmaceutical composition in accordance with claim 22 further including a compound which releases SO 3 - - ions in an aqueous state selected from the group consisting of sulfites, thiosulfates, hydrosulfites, acid bisulfites, metabisulfites and formaldehyde sodium sulfoxylate.
Claim 27
Dependent Claim
14 words
The composition in accordance with claim 24 wherein said aminoglycoside antibiotic is gentamicin complex.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-08 | 1979-12-08 | 1980-06-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-08 | 1983-12-08 | 1984-06-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-08 | 1987-12-08 | 1988-06-08 | $7700.00 | Window Closed / Lapsed |