US3961055A
Expired / Lapsed
US
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Hydroxy and ether containing phenothiazine derivatives
Assignee: Rhone Poulenc Industries SA
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Filing: 1975-01-21
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Granted: 1976-06-01
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Expires: 1995-01-21
Abstract
Abstract Phenothiazine derivatives of the formula: ##SPC1## Wherein X represents methylthio, methylsulphonyl or dimethylsulphamoyl, R represents hydrogen, alkyl of 1 through 10 carbon atoms, phenylalkyl containing 1 through 4 carbon atoms in the alkyl part, or tetrahydropyranyl, A represents --(CH 2 ) 3 -- or --CH 2 --CH(CH 3 )--CH 2 --, and R 1 represents hydrogen, alkanoyl containing 1 through 16 carbon atoms in the alkyl part or alkenoyl containing 2 through 16 carbon atoms in the alkenyl part, are new compounds possessing pharmacodynamic properties; they are particularly active as anti-emetic agents.
Inventors
- 👤 Jean Baget
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 04:31
CPC Classifications
C; C07; C07D; C07D417/00; C07D417/02; C07D417/06; C07D279/00; C07D279/10; C07D279/14; C07D279/18; C07D279/22; C07D279/24; C07D279/28
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
82 words
A phenothiazine derivative of the formula: ##SPC8## wherein X represents methylthio, methylsulphonyl or dimethylsulphamoyl, R represents hydrogen, alkyl of 1 through 10 carbon atoms, phenylalkyl containing 1 through 4 carbon atoms in the alkyl part, or tetrahydropyranyl, A represents --(CH 2 ) 3 -- or --Ch 2 --CH(CH 3 )--CH 2 --, and R 1 represents hydrogen, alkanoyl containing 1 through 16 carbon atoms in the alkyl part, or alkenoyl containing 2 to 16 carbon atoms in the alkenyl part, and non-toxic
Claim 2
Dependent Claim
82 words
A phenothiazine derivative of the formula: ##SPC8## wherein X represents methylthio, methylsulphonyl or dimethylsulphamoyl, R represents hydrogen, alkyl of 1 through 10 carbon atoms, phenylalkyl containing 1 through 4 carbon atoms in the alkyl part, or tetrahydropyranyl, A represents --(CH 2 ) 3 -- or --Ch 2 --CH(CH 3 )--CH 2 --, and R 1 represents hydrogen, alkanoyl containing 1 through 16 carbon atoms in the alkyl part, or alkenoyl containing 2 to 16 carbon atoms in the alkenyl part, and non-toxic
Claim 3
Dependent Claim
35 words
A phenothiazine compound according to claim 1 wherein R represents alkyl of 1 through 10 carbon atoms, and R 1 represents hydrogen, alkanoyl containing 4 through 16 carbon atoms in the alkyl part, or alkenoyl
Claim 4
Dependent Claim
10 words
A phenothiazine compound according to claim 1 wherein A represents
Claim 5
Dependent Claim
48 words
A phenothiazine compound according to claim 1 wherein R represents hydrogen or alkyl of 1 through 7 carbon atoms, R 1 represents hydrogen or alkanoyl containing 1 through 6 carbon atoms in the alkyl part, or alkenoyl containing 2 through 10 carbon atoms in the alkenyl part, X
Claim 6
Dependent Claim
17 words
The phenothiazine derivative according to claim 1 which is 2-methoxy-6-dimethylsulphamoyl-10-[-3(4-hydroxyethylpiperidino)propyl]phenothiazine and non-toxic pharmaceutically acceptable acid addition salts
Claim 7
Dependent Claim
16 words
The phenothiazine derivative according to claim 1 which is 2-isopropoxy-6-dimethylsulphamoyl-10-[3-(4-hydroxyethylpiperidino)propyl]phenothiazine and non-toxic pharmaceutically acceptable addition salts
Claim 8
Dependent Claim
16 words
The phenothiazine derivative according to claim 1 which is 2-heptyloxy-6-dimethylsulphamoyl-10-[3-(4-hydroxyethylpiperidino)propyl]phenothiazine and non-toxic pharmaceutically-acceptable acid addition salts
Claim 9
Dependent Claim
17 words
The phenothiazine derivative according to claim 1 which is 2-methoxy-6-dimethylsulphamoyl-10-[3-(4-heptanoyloxyethylpiperidino)propyl] phenothiazine and non-toxic pharmaceutically acid addition salts
Claim 10
Dependent Claim
15 words
The phenothiazine derivative according to claim 1 which is 2-methoxy-6-dimethylsulphamoyl-10-{3-[4-(undec-10-enoyl)oxyethylpiperidino]propyl}phenothiazine and non-toxic pharmaceutically acceptable acid
Claim 11
Dependent Claim
17 words
The phenothiazine derivative according to claim 1 which is 2-methoxy-6-dimethylsulphamoyl-10-[3-(4-acetoxyethylpiperidino)propyl]phenothiazine and non-toxic pharmaceutically acceptable acid addition salts
Claim 12
Dependent Claim
17 words
The phenothiazine derivative according to claim 1 which is 2-hydroxy-6-dimethylsulphamoyl-10-[3-(4-hydroxyethylpiperidino)propyl]phenothiazine and non-toxic pharmaceutically acceptable acid addition salts
Claim 13
Dependent Claim
42 words
A pharmaceutical composition having anti-emetic activity which comprises as active ingredient, an effective amount of a phenothiazine derivative as claimed in claim 1, or a non-toxic pharmaceutically acceptable acid addition salt thereof, in association with a significant amount of a pharmaceutical carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-01 | 1979-12-01 | 1980-06-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-01 | 1983-12-01 | 1984-06-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-01 | 1987-12-01 | 1988-06-01 | $7700.00 | Window Closed / Lapsed |