US3960911A
Expired / Lapsed
US
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Ferrocene compounds and preparation
Assignee: Fisons Ltd
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Filing: 1974-11-11
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Granted: 1976-06-01
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Expires: 1994-11-11
Abstract
Abstract There are described compounds of formula I, ##SPC1## in which R is alkyl, chlorine, bromine, phenyl, or phenyl substituted by one or more halogen or alkyl groups, One of X and Y is group --CO--, --CHOH-- or --CH 2 -- and the other is an exocyclic carbon-carbon bond linking the ferrocenyl or the R group respectively to the -A- group, A contains 5, 6 or 7 carbon atoms and is an ethylenically unsaturated (the double bond being connected to the carbon atom which is connected to X), unsubstituted (except by X and Y) cyclic hydrocarbon group; or is a saturated cyclic hydrocarbon group substituted by X and Y and, when X is a group --CO-, optionally substituted on the carbon atom to which Y is attached by an -OH group, and X and Y are attached to adjacent carbon atoms on the A group. There are also described processes for the production of compounds of formula I and haematinic compositions containing them.
Inventors
- 👤 John Louis Suschitzky
- 👤 David Rutherford
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 01:46
CPC Classifications
C; C07; C07F; C07F17/00; C07F17/02
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
87 words
A process for the production of a compound of the formula ##SPC10## which comprises cyclizing and dehydrating a compound of the formula ##SPC11## in which formula L is an unsubstituted cycloalkene group containing 5, 6 or 7 carbon atoms with the sole double bond therein being connected to the carbon atoms which is directly connected to the ferrocenyl radical, n is one of the integers 4, 5 or 6 and R is alkyl, chlorine, bromine, phenyl, or phenyl substituted by one or more halogen or alkyl groups.
Claim 2
Dependent Claim
87 words
A process for the production of a compound of the formula ##SPC10## which comprises cyclizing and dehydrating a compound of the formula ##SPC11## in which formula L is an unsubstituted cycloalkene group containing 5, 6 or 7 carbon atoms with the sole double bond therein being connected to the carbon atoms which is directly connected to the ferrocenyl radical, n is one of the integers 4, 5 or 6 and R is alkyl, chlorine, bromine, phenyl, or phenyl substituted by one or more halogen or alkyl groups.
Claim 3
Dependent Claim
68 words
A compound of the formulas ##SPC12## in which R is alkyl, chlorine, bromine, phenyl, or phenyl substituted by one or more halogen or alkyl groups, X is a group --CO--, --CHOH or --CH 2 --, Y is a group --CO--, --CHOH or --CH 2 --, m is an integer from 1 to 3, and R 1 is hydrogen, or is hydrogen or --OH when X is -CO-. .
Claim 4
Dependent Claim
68 words
A compound of the formulas ##SPC12## in which R is alkyl, chlorine, bromine, phenyl, or phenyl substituted by one or more halogen or alkyl groups, X is a group --CO--, --CHOH or --CH 2 --, Y is a group --CO--, --CHOH or --CH 2 --, m is an integer from 1 to 3, and R 1 is hydrogen, or is hydrogen or --OH when X is -CO-. .
Claim 5
Dependent Claim
14 words
A compound according to formula (4) of claim 2 in which Y is --CO-.
Claim 6
Dependent Claim
27 words
A compound according to claim 2 wherein R is phenyl or a phenyl mono-substituted by chlorine or fluorine or by alkyl containing 1 to 10 carbon atoms.
Claim 7
Dependent Claim
12 words
A compound according to claim 2 wherein m is 1 or 2.
Claim 8
Dependent Claim
10 words
A compound according to claim 2 wherein m is 1.
Claim 9
Dependent Claim
11 words
A compound according to formulas (2) and (4) of claim 2.
Claim 10
Dependent Claim
13 words
A compound according to formula (3) of claim 2 when Y is --CO-.
Claim 11
Dependent Claim
36 words
A compound according to formula (4) of claim 2 in which Y is --CO-, m is 1 and R is phenyl or a phenyl substituted by a single chlorine atom, or by a single methyl group.
Claim 12
Dependent Claim
11 words
A compound according to formula (4) of claim 2 named 1-benzoyl-2-ferrocenylcyclopentene.
Claim 13
Dependent Claim
19 words
A compound according to claim 2 which is 1-ferrocenoyl-2-phenylcyclopentene, 1-benzyl-2-ferrocenylcyclopentane, 1-(α-hydroxybenzyl)-2-ferrocenylcyclopentane, 1-benzoyl-2-ferrocenyl-cyclopentane, 1-ferrocenyl-2-(4-chlorobenzoyl)cyclopent-1-ene, 1-ferrocenyl-2-(3-methylbenzoyl)cyclopent-1-ene, 3-benzoyl-2-ferrocenylcyclohexene, 1-ferrocenoyl-2-hydroxy-2-phenylcyclohexane, 1-chloro-2-ferrocenoylcyclopent-1-ene, or 1-ferrocenyl-2-(2-fluorobenzoyl)cyclopent-1-ene.
Claim 14
Dependent Claim
20 words
A compound according to claim 2 in solid particulate form having a mass median diameter of less than 10 microns.
References Cited (Backward Citations)
US2831879A
Cited
US3711280A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-01 | 1979-12-01 | 1980-06-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-01 | 1983-12-01 | 1984-06-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-01 | 1987-12-01 | 1988-06-01 | $7700.00 | Window Closed / Lapsed |