US3960895A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aryl ketals of polycyclic oxo compounds and processes
Assignee: Hoffmann La Roche Inc
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Filing: 1975-06-09
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Granted: 1976-06-01
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Expires: 1995-06-09
Abstract
Abstract The intermediates and processes of this disclosure provide a new stereo-specific total synthesis of steroidal materials having known valuable pharmacological properties. A fundamental feature of this disclosure is the utilization of aryl ketals, preferably phenylenedioxy ketals derived from catechol as protective groups for oxo moieties in the polycyclic intermediates used in the aforesaid total synthesis.
Inventors
- 👤 Michael Rosenberger
- 👤 Gabriel Saucy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 14:18
CPC Classifications
C; C07; C07D; C07D317/00; C07D317/08; C07D317/44; C07D311/00; C07D311/02; C07D311/78; C07J; C07J1/00; C07J75/00; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
173 words
A process for the preparation of a compound of the formula ##SPC22## wherein Y is ##EQU5## B is the remaining residue of a phenylene, 4,5-dimethylphenylene or 2,3-naphthalene moiety; R 1 is a primary alkyl group of from 1 to 5 carbon atoms; R 2 is hydrogen, lower primary alkyl or lower alkanoyl; R 5 , R 11 , R 12 , R 14 and R 15 are each independently hydrogen or lower alkyl; Z is carbonyl or a group of the formula ##EQU6## R 7 is hydrogen or lower alkanoyl; R 8 is hydrogen or lower aliphatic hydrocarbyl and m is an integer having a a value of 1 to 2 which comprises reacting a compound of the formula ##SPC23## wherein R 1 , R 11 , R 12 , Y, Z and m have the same meaning as above with a compound of the formula R 2 OH wherein R 2 has the same meaning as above in the presence of an acid catalyst and a cosolvent wherein R 2 is hydrogen.
Claim 2
Dependent Claim
173 words
A process for the preparation of a compound of the formula ##SPC22## wherein Y is ##EQU5## B is the remaining residue of a phenylene, 4,5-dimethylphenylene or 2,3-naphthalene moiety; R 1 is a primary alkyl group of from 1 to 5 carbon atoms; R 2 is hydrogen, lower primary alkyl or lower alkanoyl; R 5 , R 11 , R 12 , R 14 and R 15 are each independently hydrogen or lower alkyl; Z is carbonyl or a group of the formula ##EQU6## R 7 is hydrogen or lower alkanoyl; R 8 is hydrogen or lower aliphatic hydrocarbyl and m is an integer having a a value of 1 to 2 which comprises reacting a compound of the formula ##SPC23## wherein R 1 , R 11 , R 12 , Y, Z and m have the same meaning as above with a compound of the formula R 2 OH wherein R 2 has the same meaning as above in the presence of an acid catalyst and a cosolvent wherein R 2 is hydrogen.
References Cited (Backward Citations)
US3655695A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-01 | 1979-12-01 | 1980-06-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-01 | 1983-12-01 | 1984-06-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-01 | 1987-12-01 | 1988-06-01 | $7700.00 | Window Closed / Lapsed |