US3960876A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Certain 1-carbothioamides of 1,8-naphthyridines, pyrrolo(2,3-b)pyridines and pyrido(2,3-b)azepines
Assignee: John Wyeth and Brother Ltd
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Filing: 1975-02-28
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Granted: 1976-06-01
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Expires: 1995-02-28
Abstract
Abstract The invention relates to thioureas which are derivatives of organic nitrogen compounds containing a pyridine ring to which is fused a saturated nitrogen containing ring which carries on its nitrogen atom a thioamide or substituted thioamide group. The compounds are anti-ulcer agents or intermediates therefor.
Inventors
- 👤 Adrian Charles Ward Curran
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 00:25
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
128 words
A compound of formula (I) ##SPC5## or a pharmaceutically acceptable acid addition salt thereof wherein R 1 , R 2 and R 3 are the same or different and represent a hydrogen atom or a lower alkyl, phenyl lower alkyl or, phenyl radical, any of which radicals may be substituted by lower alkyl, lower alkoxy, halogen, nitro or trifluoromethyl, Q is the group ##EQU2## wherein N of said group is directly attached to the alpha carbon of pyridine ring, m is 1, 2 or 3, and the group Q may be substituted by lower alkyl, phenyl lower alkyl, or phenyl radicals any of which radicals may be substituted by lower alkyl, lower alkoxy, halogen, nitro or trifluoromethyl and R 4 is hydrogen or alkyl of 1-3 carbon atoms.
Claim 2
Dependent Claim
128 words
A compound of formula (I) ##SPC5## or a pharmaceutically acceptable acid addition salt thereof wherein R 1 , R 2 and R 3 are the same or different and represent a hydrogen atom or a lower alkyl, phenyl lower alkyl or, phenyl radical, any of which radicals may be substituted by lower alkyl, lower alkoxy, halogen, nitro or trifluoromethyl, Q is the group ##EQU2## wherein N of said group is directly attached to the alpha carbon of pyridine ring, m is 1, 2 or 3, and the group Q may be substituted by lower alkyl, phenyl lower alkyl, or phenyl radicals any of which radicals may be substituted by lower alkyl, lower alkoxy, halogen, nitro or trifluoromethyl and R 4 is hydrogen or alkyl of 1-3 carbon atoms.
Claim 3
Dependent Claim
22 words
A compound as claimed in claim 1, wherein R 1 , R 2 and R 3 are selected from hydrogen and methyl.
Claim 4
Dependent Claim
12 words
A compound as claimed in claim 1, wherein R 4 is methyl.
Claim 5
Dependent Claim
32 words
A compound as claimed in claim 1, which has formula (Ia) ##SPC6## wherein R 1 , R 2 , R 3 , R 4 and m are as defined in claim 1.
Claim 6
Dependent Claim
42 words
A compound as claimed in claim 1 which has formula II. ##SPC7## or a pharmaceutically acceptable acid addition salt thereof wherein R 1 , R 2 and R 3 are as defined in claim 1 and R 5 is hydrogen or methyl.
Claim 7
Dependent Claim
19 words
A compound as claimed in claim 1, which is 6,7,8,9-Tetrahydro-9-(N-methylthiocarboxamido)-5H-pyrido[2,3-b] azepine or a pharmaceutically acceptable acid addition salt thereof.
Claim 8
Dependent Claim
10 words
A compound as claimed in claim 1, which is 1,2,3,4-tetrahydro-1-(N-methylthiocarboxamido)-1,8-naphthyridine.
Claim 9
Dependent Claim
10 words
A compound as claimed in claim 1 which is 2,3-dihydro-N-methyl-1H-pyrrolo[2,3-b]pyridine-1-carbothioamide.
Claim 10
Dependent Claim
10 words
A compound as claimed in claim 1 which is 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-carbothioamide.
References Cited (Backward Citations)
US3149104A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-01 | 1979-12-01 | 1980-06-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-01 | 1983-12-01 | 1984-06-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-01 | 1987-12-01 | 1988-06-01 | $7700.00 | Window Closed / Lapsed |