US3960868A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Derivatives of 6,7 or 8 cycloalkyl 4-oxo quinoline 3 carboxylic acid
Assignee: Novartis Corp
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Filing: 1974-05-06
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Granted: 1976-06-01
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Expires: 1994-05-06
Abstract
Abstract ##SPC1## wherein Ph denotes a 1,2-phenylene radical which carries cycloaliphatic radical, R x denotes a free or etherified hydroxyl group or a free or substituted amino group, R o denotes an alkyl radical, a free hydroxyl group or a hydroxyl group etherified by lower alkyl or, above all, a hydrogen atom and R 1 denotes an aliphatic or cycloaliphatic hydrocarbon radical which is optionally substituted by hydroxyl, an araliphatic radical or a hydrogen atom, and their salts, which possess valuable analgesic, anti-inflammatory, anti-microbial and histamine liberation inhibiting properties.
Inventors
- 👤 Pier Giorgio Ferrini
- 👤 Georges Haas
- 👤 Alberto Rossi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:36
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/20; C07D215/22; A; A61; A61P; A61P31/00; A61P31/12; C07D215/48; C07D215/54; C07D215/56; C07D265/00; C07D265/04; C07D265/12; C07D265/14; C07D265/24; C07D265/26
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
104 words
A product of the formula ##SPC15## wherein R o denotes hydrogen or hydroxy, R 1 denotes hydrogen, alkyl, aklenyl or phenyl-alkyl having up to 8 carbon atoms R 2 is bound in the positions 6, 7 or 8 of the quinoline moiety and represents cycloalkyl or cycloalkenyl with 5-8 ring members, or 1-adamantyl, R 3 denotes lower alkyl, halogen or hydrogen and R x denotes hydroxy, alkoxy with up to 8 carbon atoms, amino, N-mono-lower alkylamino, N,N-di-lower alkylamino or anilino, wherein the term "lower" denotes said moieties having up to 4 carbon atoms; or a tautomeric form thereof, or a therapeutically acceptable salt thereof.
Claim 2
Dependent Claim
104 words
A product of the formula ##SPC15## wherein R o denotes hydrogen or hydroxy, R 1 denotes hydrogen, alkyl, aklenyl or phenyl-alkyl having up to 8 carbon atoms R 2 is bound in the positions 6, 7 or 8 of the quinoline moiety and represents cycloalkyl or cycloalkenyl with 5-8 ring members, or 1-adamantyl, R 3 denotes lower alkyl, halogen or hydrogen and R x denotes hydroxy, alkoxy with up to 8 carbon atoms, amino, N-mono-lower alkylamino, N,N-di-lower alkylamino or anilino, wherein the term "lower" denotes said moieties having up to 4 carbon atoms; or a tautomeric form thereof, or a therapeutically acceptable salt thereof.
Claim 3
Dependent Claim
83 words
A product as claimed in claim 1 in which formula R o represents hydrogen or hydroxy, R 1 denotes hydrogen, C 1 -C 4 -alkyl, C 3 -C 4 -alkenyl or -phenyl-C 1 -C 2 -alkyl-, R 2 denotes cycloalkyl or cycloalkenyl with 5 to 8 ring members or 1-adamantyl bound in 6-, 7- or 8-position of the quinoline moiety, R 3 denotes hydrogen or halogen and R x denotes hydroxy, C 1 -C 3 -alkoxy or anilino; or a tautomeric form thereof.
Claim 4
Dependent Claim
18 words
A compound as claimed in claim 1 and being the 8-cyclohexyl-1-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, or a therapeutically acceptable salt thereof.
Claim 5
Dependent Claim
18 words
A compound as claimed in claim 1 and being the 6-cyclohexyl-1-ethyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, or a therapeutically acceptable salt thereof.
Claim 6
Dependent Claim
20 words
A compound as claimed in claim 1 and being the 6-cyclohexyl-4-hydroxy-quinoline-3-carboxylic acid ethyl ester, or a therapeutically acceptable salt thereof.
Claim 7
Dependent Claim
18 words
A compound as claimed in claim 1 and being the 6-cyclohexyl-4-hydroxy-quinoline-3-carboxylic acid, or a therapeutically acceptable salt thereof.
Claim 8
Dependent Claim
18 words
A compound as claimed in claim 1 and being the 7-cyclohexyl-4-hydroxy-quinoline-3-carboxylic acid, or a therapeutically acceptable salt thereof.
Claim 9
Dependent Claim
18 words
A compound as claimed in claim 1 and being the 7-cyclohexyl-1-ethyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, or a therapeutically acceptable salt thereof.
Claim 10
Dependent Claim
18 words
A compound as claimed in claim 1 and being the 8-cyclohexyl-4-hydroxy-quinoline-3-carboxylic acid, or a therapeutically acceptable salt thereof.
Claim 11
Dependent Claim
20 words
A compound as claimed in claim 1 and being the 6-cycloheptyl-1-ethyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester, or a therapeutically acceptable salt thereof.
Claim 12
Dependent Claim
18 words
A compound as claimed in claim 1 and being the 7-chloro-6-cyclohexyl-1-ethyl-4-oxo-1,4-dihydro-3-carboxylic acid, or a therapeutically acceptable salt thereof.
References Cited (Backward Citations)
GB830832A
Cited
US3452026A
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US3542851A
Cited
US3761592A
Cited
US3506667A
Cited
US3849421A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-01 | 1979-12-01 | 1980-06-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-01 | 1983-12-01 | 1984-06-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-01 | 1987-12-01 | 1988-06-01 | $7700.00 | Window Closed / Lapsed |