US3960863A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pyrido[1,2-a]pyrimidinone derivatives
Assignee: Sankyo Co Ltd
•
Filing: 1975-06-05
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Granted: 1976-06-01
•
Expires: 1995-06-05
Abstract
Abstract 3-[2-(4-PHENYL-1-PIPERAZINYL)ETHYL]-4H-pyrido[1,2-a]pyrimidin-4-one derivatives have central nervous depressant and hypotensive activities and are useful as major tranquillizers. The compounds can be prepared by (a) reacting 2-methyl-3-halogeno (or arylsulfonyloxy or alkylsulfonyloxy)ethyl-4H-pyrido[1,2-a]pyrimidin-4-one derivative with 1-phenylpiperazine derivative or (b) reacting an aminopyridine with 2-[2-(4-phenyl-1-piperazinyl)ethyl]-acetoacetic acid ester.
Inventors
- 👤 Yasunobu Sato
- 👤 Hiroshi Fujita
- 👤 Takagi
- 👤 Katsuo Kamoshita
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 06:06
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
78 words
Pyrido[1,2-a]pyrimidinone derivative having the formula ##SPC6## wherein R 1 and R 2 may be the same or different and each represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms or a halogen atom and X represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, trifluoromethyl group or a halogen atom and a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
78 words
Pyrido[1,2-a]pyrimidinone derivative having the formula ##SPC6## wherein R 1 and R 2 may be the same or different and each represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms or a halogen atom and X represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, trifluoromethyl group or a halogen atom and a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
1 words
3-[2-(4-m-Tolyl-1-piperazinyl)ethyl]-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one.
Claim 4
Dependent Claim
1 words
3-[2-(4-m-Tolyl-1-piperazinyl)ethyl]-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one.
Claim 5
Dependent Claim
1 words
3-[2-(4-m-Chlorophenyl-1-piperazinyl)ethyl]-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one.
Claim 6
Dependent Claim
1 words
3-[2-(4-m-Chlorophenyl-1-piperazinyl)ethyl]-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one.
Claim 7
Dependent Claim
1 words
3-[2-(4-m-Methoxyphenyl-1-piperazinyl)ethyl]-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one.
Claim 8
Dependent Claim
1 words
3-[2-(4-m-Methoxyphenyl-1-piperazinyl)ethyl]-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one.
Claim 9
Dependent Claim
1 words
3-[2-(4-p-Chlorophenyl-1-piperazinyl)ethyl]-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one.
Claim 10
Dependent Claim
1 words
3-[2-(4-p-Chlorophenyl-1-piperazinyl)ethyl]-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one.
Claim 11
Dependent Claim
1 words
3-[2-(4-m-Tolyl-1-piperazinyl)ethyl]-2,6,8-trimethyl-4H-pyrido[1,2-a]pyrimidin-4-one.
Claim 12
Dependent Claim
1 words
3-[2-(4-m-Tolyl-1-piperazinyl)ethyl]-2,6,8-trimethyl-4H-pyrido[1,2-a]pyrimidin-4-one.
Claim 13
Dependent Claim
1 words
3-[2-(4-m-Tolyl-1-piperazinyl)ethyl]-2,9-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one.
Claim 14
Dependent Claim
1 words
3-[2-(4-m-Tolyl-1-piperazinyl)ethyl]-2,9-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one.
Claim 15
Dependent Claim
1 words
3-[2-(4-p-Tolyl-1-piperazinyl)ethyl]-2,9-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one.
Claim 16
Dependent Claim
1 words
3-[2-(4-p-Tolyl-1-piperazinyl)ethyl]-2,9-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-01 | 1979-12-01 | 1980-06-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-01 | 1983-12-01 | 1984-06-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-01 | 1987-12-01 | 1988-06-01 | $7700.00 | Window Closed / Lapsed |