US3960727A
Expired / Lapsed
US
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Apparatus and method for isolating soluble blood components
Assignee: Individual
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Filing: 1974-08-09
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Granted: 1976-06-01
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Expires: 1994-08-09
Abstract
Abstract A method is disclosed for isolating blood serum from clotted whole blood and for isolating blood plasma from mixtures of whole blood with anti-coagulants. The method comprises partially sinking an apparatus of the invention in the appropriate blood specimen, conveniently with the assistance of centrifugation. The apparatus of the invention comprises a hollow elongate body open at both ends. One end is partially closed with a filter member which prevents the passage of solid phase components of clotted whole blood and solid phase components of mixtures of blood with anti-coagulants but allows passage of blood serum or blood plasma.
Inventors
- 👤 Harry T. Hochstrasser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 18:12
CPC Classifications
B; B01; B01L; B01L3/00; B01L3/50; B01L3/502; B01L3/5021; B01D; B01D33/00; B01D33/01
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
207 words
An assembly for isolating the soluble components from the insoluble components of blood mixtures selected from coagulated whole blood and mixtures of whole blood with anti-coagulants which comprises: i. a blood collection container for holding a blood specimen to be separated and having an opening therein; and ii. a separating apparatus inserted in the opening of said container, having a diameter less than the width of said collection chamber so that said apparatus fits loosely within said collection container and does not form an interference fit with the inner walls of said container; said apparatus comprising: an elongate body defining a central bore which has an upper portion and a lower portion; said body having a first end which is open and communicates freely between the exterior and the upper portion of said bore and a second end which is open and communicates between the exterior and the lower portion of said bore; a filter member located adjacent to said second end and being interposed between the body exterior and the lower portion of said bore, said filter member having pore sizes which permit the passage of soluble blood components but prevent passage of insoluble blood components; and said apparatus having a specific gravity of between 0.3-1.3.
Claim 2
Dependent Claim
207 words
An assembly for isolating the soluble components from the insoluble components of blood mixtures selected from coagulated whole blood and mixtures of whole blood with anti-coagulants which comprises: i. a blood collection container for holding a blood specimen to be separated and having an opening therein; and ii. a separating apparatus inserted in the opening of said container, having a diameter less than the width of said collection chamber so that said apparatus fits loosely within said collection container and does not form an interference fit with the inner walls of said container; said apparatus comprising: an elongate body defining a central bore which has an upper portion and a lower portion; said body having a first end which is open and communicates freely between the exterior and the upper portion of said bore and a second end which is open and communicates between the exterior and the lower portion of said bore; a filter member located adjacent to said second end and being interposed between the body exterior and the lower portion of said bore, said filter member having pore sizes which permit the passage of soluble blood components but prevent passage of insoluble blood components; and said apparatus having a specific gravity of between 0.3-1.3.
Claim 3
Dependent Claim
15 words
An apparatus of claim 1 wherein said filter member is an open cell polyurethane foam.
Claim 4
Dependent Claim
12 words
An apparatus of claim 1 wherein said elongate body is a cylinder.
Claim 5
Dependent Claim
16 words
An apparatus of claim 1 wherein said filter member has pore sizes of about 50 microns.
Claim 6
Dependent Claim
11 words
An apparatus of claim 1 wherein said elongate body is collapsible.
Claim 7
Dependent Claim
29 words
An apparatus of claim 1 wherein said elongate body comprises an upper inflexible member, a lower inflexible member and an interposed foldable member joining said upper and lower members.
Claim 8
Dependent Claim
40 words
The assembly of claim 1 wherein the collection container is a tubular container having one open end and said apparatus elongate member has a diameter of about 2 to about 5 percent less than the diameter of said collection container.
Claim 9
Independent Claim
218 words
A method of isolating the soluble components from the insoluble components of a blood mixture held in a blood collection container and which is selected from coagulated whole blood and mixtures of whole blood with anti-coagulants which consists of placing in said blood mixture an apparatus which comprises; an elongate body defining a central bore which has an upper portion and a lower portion; said body having a first end which is open and communicates freely between the exterior and the upper portion of said bore and a second end which is open and communicates between the exterior and the lower portion of said bore; a filter member located adjacent to said second end and being interposed between the body exterior and the lower portion of said bore, said filter member having pore sizes which permit the passage of soluble blood components but prevent passage of insoluble blood components; said apparatus having a specific gravity of between about 0.3 and 1.3; said apparatus having a diameter which is less than the width of said collection container so that said apparatus is loosely disposed within said blood collection container when emplaced in said blood mixture and does not form an interference fit with the inner walls of said container; and centrifuging said blood mixture with said apparatus emplaced thereon.
Claim 10
Independent Claim
218 words
A method of isolating the soluble components from the insoluble components of a blood mixture held in a blood collection container and which is selected from coagulated whole blood and mixtures of whole blood with anti-coagulants which consists of placing in said blood mixture an apparatus which comprises; an elongate body defining a central bore which has an upper portion and a lower portion; said body having a first end which is open and communicates freely between the exterior and the upper portion of said bore and a second end which is open and communicates between the exterior and the lower portion of said bore; a filter member located adjacent to said second end and being interposed between the body exterior and the lower portion of said bore, said filter member having pore sizes which permit the passage of soluble blood components but prevent passage of insoluble blood components; said apparatus having a specific gravity of between about 0.3 and 1.3; said apparatus having a diameter which is less than the width of said collection container so that said apparatus is loosely disposed within said blood collection container when emplaced in said blood mixture and does not form an interference fit with the inner walls of said container; and centrifuging said blood mixture with said apparatus emplaced thereon.
Claim 11
Dependent Claim
14 words
A method according to claim 8 wherein said blood mixture is coagulated whole blood.
Claim 12
Dependent Claim
18 words
A method according to claim 8 wherein said blood mixture is a mixture of whole blood with anti-coagulants.
Claim 13
Dependent Claim
12 words
A method according to claim 8 wherein said elongate body is collapsible.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-01 | 1979-12-01 | 1980-06-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-01 | 1983-12-01 | 1984-06-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-01 | 1987-12-01 | 1988-06-01 | $7700.00 | Window Closed / Lapsed |