US3959338A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-(Cyano-phenoxy)-2-hydroxy-3-hydroxyalkylamino-propanes and salts thereof
Assignee: Boehringer Ingelheim GmbH
•
Filing: 1974-03-18
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Granted: 1976-05-25
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Expires: 1994-03-18
Abstract
Abstract Racemic or optically active compounds of the formula O-CH2-CH(OH)-CH2-NH-R2 wherein R1 is hydrogen, halogen, alkyl or 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms, and R2 is straight or branched hydroxyalkyl of 3 to 6 carbon atoms, AND NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF; THE COMPOUNDS AS WELL AS THE SALTS ARE USEFUL beta -ADRENERGIC RECEPTOR BLOCKING AGENTS AND HYPOTENSIVES.
Inventors
- 👤 Herbert Koppe
- 👤 Helmut Stahle
- 👤 Werner Kummer
- 👤 Werner Traunecker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 09:55
CPC Classifications
C; C07; C07D; C07D317/00; C07D317/08; C07D317/44; C07D317/46; C07D317/48; C07D317/62; C07D317/64
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
62 words
A racemic or optically active compound of the formula ##EQU14## wherein R 1 is hydrogen, chlorine, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms, and R 2 is straight or branched monohydroxyalkyl of 3 to 4 carbon atoms, or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
62 words
A racemic or optically active compound of the formula ##EQU14## wherein R 1 is hydrogen, chlorine, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms, and R 2 is straight or branched monohydroxyalkyl of 3 to 4 carbon atoms, or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
30 words
A compound of claim 1, wherein R 1 is hydrogen or alkyl of 1 to 4 carbon atoms, and R 2 is branched monohydroxyalkyl of 3 to 4 carbon atoms.
Claim 4
Dependent Claim
24 words
A compound of claim 1, wherein R 1 is hydrogen or methyl, and R 2 is branched monohydroxyalkyl of 3 to 4 carbon atoms.
Claim 5
Dependent Claim
18 words
A compound according to claim 1, which is 1-(2'-cyano-phenoxy)-2-hydroxy-3-[(1",1"-dimethyl-2"-hydroxy-ethyl)-amino]-propane or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
18 words
A compound according to claim 1, which is 1-(2'-cyano-5'-methyl-phenoxy)-2-hydroxy-3-[(1",1"-dimethyl-2"-hydroxy-ethyl)-amino]-propane or a non-toxic, pharmacologically acceptable acid addition salt thereof.
References Cited (Backward Citations)
US3541130A
Cited
US3663607A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-05-25 | 1979-11-24 | 1980-05-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-05-25 | 1983-11-24 | 1984-05-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-05-25 | 1987-11-24 | 1988-05-25 | $7700.00 | Window Closed / Lapsed |