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US3959263A Expired / Lapsed US ⏱️ 0.0 years remaining

Prostaglandin intermediate

Assignee: Wyeth LLC
•
Filing: 1974-06-19
•
Granted: 1976-05-25
•
Expires: 1994-06-19
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Abstract

Abstract Prostaglandin derivatives of the formula ##SPC1## In which R 4 , R 5 , R 6 and R 7 each are hydrogen or lower alkyl, X is hydroxy and Y is hydrogen or X and Y together are oxo, Z is CH 2 CH 2 or trans CH=CH, m is an integer from one to three and n is an integer from two to five, with the proviso that at least one of R 4 , R 5 or R 6 is hydrogen, are disclosed together with a process for their preparation. The compounds in which Z is CH 2 CH 2 and the process are new. The new derivatives possess hypotensive, antihypertensive, bronchospasmolytic, gastric acid secretion inhibiting, abortifacient, estrus synchronizing and ovulation regulating properties. These compounds also inhibit the aggregation of platelets and promote the disaggregation of aggregated platelets. Methods for their use are also disclosed.

Inventors

  • 👤 Nedumparambil A. Abraham
  • 👤 Jehan F. Bagli
  • 👤 Tibor Bogri

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-24 08:55
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/77; C07D307/93; C07D307/935; C07C; C07C405/00; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/12; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/40; C07F9/4003; C07F9/4006; C07F9/54; C07F9/5407; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55

Claims Analysis

Total Claims: 6
Claim 1
Independent Claim 79 words
A compound of the formula ##SPC11## in which R 1 and R 3 each are lower alkyl, R 2 is hydrogen or a hydroxy protecting radical selected from the group consisting of acetals, tri (lower) alkylsilyl or tert-butyl, R 4 , R 5 and R 6 each are hydrogen or lower alkyl and n is an integer from two to five, with the proviso that at least one of R 4 , R 5 or R 6 is hydrogen.
Claim 2
Dependent Claim 79 words
A compound of the formula ##SPC11## in which R 1 and R 3 each are lower alkyl, R 2 is hydrogen or a hydroxy protecting radical selected from the group consisting of acetals, tri (lower) alkylsilyl or tert-butyl, R 4 , R 5 and R 6 each are hydrogen or lower alkyl and n is an integer from two to five, with the proviso that at least one of R 4 , R 5 or R 6 is hydrogen.
Claim 3
Dependent Claim 7 words
Dimethyl trans-1-(Carbomethoxymethyl)-5-(3-hydroxy-1-octenyl)-2-oxo-1,3-cyclopentanedicarboxylate, as claimed in claim 1.
Claim 4
Dependent Claim 17 words
The compound of claim 2 in the form of its tetrahydropyran-2-yl ether, as claimed in claim 1.
Claim 5
Dependent Claim 7 words
Dimethyl trans-1-(Carboethoxymethyl)-5-(3-hydroxy-3-methyl-1-octenyl)-2-oxo-1,3-cyclopentanedicarboxylate, as claimed in claim 1.
Claim 6
Dependent Claim 7 words
Dimethyl trans-1-(Carboxymethoxymethyl)-5-(3-hydroxy-4,4-dimethyl-1-octenyl)-2-oxo-1,3-cyclopentanedicarboxylate, as claimed in claim 1.

References Cited (Backward Citations)

US3849474A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1979-05-25 1979-11-24 1980-05-25 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1983-05-25 1983-11-24 1984-05-25 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1987-05-25 1987-11-24 1988-05-25 $7700.00 Window Closed / Lapsed

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