US3958008A
Expired / Lapsed
US
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Anthelmintic methods of use
Assignee: Nippon Soda Co Ltd
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Filing: 1970-12-28
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Granted: 1976-05-18
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Expires: 1990-12-28
Abstract
Abstract The thioallophanate compound represented by the following general formula ##EQU1## wherein X is hydrogen, chlorine atom, nitro or methyl group: Z is a substituting group selected from the group consisting of ##EQU2## and ##EQU3## has excellent anthelmintic activity and can be used for controlling helminthiasis of animals.
Inventors
- 👤 Yoshinobu Hashimoto
- 👤 Kinpei Kato
- 👤 Nobuo Sato
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 17:25
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/12
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
68 words
A method for the treatment of helminth infections in man and domestic animals which comprises administering to man or a domestic animal infected with helminths an anthelmintically effective amount of a benzene derivative selected from the group consisting of: 2-(3-ethoxycarbonyl-2-thioureido)-N,N-dimethylaniline, 2-(3-ethoxycarbonyl-2-thioureido)-N,N-dimethylaniline hydrochloride, 1-(3-ethoxycarbonyl-2-thioureido)2-N,N-dimethyl-amino-benzene oxalate, 1-formamido-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-acetamido-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-propionamido-2-(3-ethoxycarbonyl-2-thioureido)-benzene, 1-cyclopropancarbonamido-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-benzamido-2-(3-ethoxycarbonyl-2-thioureido)-benzene, 1-methoxycarbonamido-2-(3-ethoxycarbonyl-2-thioureido)-benzene, 1-ethoxycarbonamido-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-(3-n-propylureido)-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-(3-n-butylureido)-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-(3-n-butylureido)-2-(3-ethoxycarbonyl-2-thioureido)-benzene, 1-thioformamido-2-(3-ethoxycarbonyl-2-thioureido)-benzene, 1-(2-thiocarbamoyl-aminophenyl)-3-ethoxycarbonylthiourea, 1-(3-ethoxycarbonyl-2-thioureido)-2-(3-methyl-2-thioureido)-benzene, 1-(3-n-propyl-2-thioureido)-2-(3-ethoxycarbonyl-2-thioureido)-benzene, 1-(3-N,N-dimethylamino-2-thiocarbonyl-2-thioureido)-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-(3-N,N-dimethylaminothiocarbonyl-2-thioureido)-2-(3-ethoxycarbonyl-2-thioureido)-benzene, 1-(3-N,N-dimethylamino-carbonyl-2-thioureido)-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-benzylidenamino-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-(4-chlorobenzylidenamino)-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-(4-methoxybenzylidenamino)-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-(3-nitrobenzylidenamino-2-(3-ethoxycarbonyl-2-thioureido)-benzene, 1-benzenesulfonicamido-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-(4-toluenesulfonicamido)-2-(3-ethoxycarbonyl-2-thioureido)-benzene 1(4-chlorobenzenesulfonicamodo)-2-(3-methoxycarbonyl-2-thioureido)-benzene,
Claim 2
Independent Claim
68 words
A method for the treatment of helminth infections in man and domestic animals which comprises administering to man or a domestic animal infected with helminths an anthelmintically effective amount of a benzene derivative selected from the group consisting of: 2-(3-ethoxycarbonyl-2-thioureido)-N,N-dimethylaniline, 2-(3-ethoxycarbonyl-2-thioureido)-N,N-dimethylaniline hydrochloride, 1-(3-ethoxycarbonyl-2-thioureido)2-N,N-dimethyl-amino-benzene oxalate, 1-formamido-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-acetamido-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-propionamido-2-(3-ethoxycarbonyl-2-thioureido)-benzene, 1-cyclopropancarbonamido-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-benzamido-2-(3-ethoxycarbonyl-2-thioureido)-benzene, 1-methoxycarbonamido-2-(3-ethoxycarbonyl-2-thioureido)-benzene, 1-ethoxycarbonamido-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-(3-n-propylureido)-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-(3-n-butylureido)-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-(3-n-butylureido)-2-(3-ethoxycarbonyl-2-thioureido)-benzene, 1-thioformamido-2-(3-ethoxycarbonyl-2-thioureido)-benzene, 1-(2-thiocarbamoyl-aminophenyl)-3-ethoxycarbonylthiourea, 1-(3-ethoxycarbonyl-2-thioureido)-2-(3-methyl-2-thioureido)-benzene, 1-(3-n-propyl-2-thioureido)-2-(3-ethoxycarbonyl-2-thioureido)-benzene, 1-(3-N,N-dimethylamino-2-thiocarbonyl-2-thioureido)-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-(3-N,N-dimethylaminothiocarbonyl-2-thioureido)-2-(3-ethoxycarbonyl-2-thioureido)-benzene, 1-(3-N,N-dimethylamino-carbonyl-2-thioureido)-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-benzylidenamino-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-(4-chlorobenzylidenamino)-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-(4-methoxybenzylidenamino)-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-(3-nitrobenzylidenamino-2-(3-ethoxycarbonyl-2-thioureido)-benzene, 1-benzenesulfonicamido-2-(3-methoxycarbonyl-2-thioureido)-benzene, 1-(4-toluenesulfonicamido)-2-(3-ethoxycarbonyl-2-thioureido)-benzene 1(4-chlorobenzenesulfonicamodo)-2-(3-methoxycarbonyl-2-thioureido)-benzene,
Claim 3
Dependent Claim
14 words
2-bis(3-benzyloxycarbonyl-2-thioureido)-benzene, 1.2-bis[3-(β-methoxy) ethoxycarbonyl-2-thioureido]benzene, 1.2-bis]3-(β-chloroethoxycarbonyl)-2-thioureido]benzene, 1.2-bis(3-allyloxycarbonyl-2-thioureido)benzene, 1.2-bis[3-(2-propynyloxycarbonyl)-2-thioureido] benzene, 1.2-bis[3-(4-chlorophenoxycarbonyl)-2-thioureido]benzene, 1.2-bis[3-(4-nitrophenoxycarbonyl)-2-thioureido]benzene, 1.2-bis[3-(4-methylphenoxycarbonyl)-2-thioureido]-4-chlorobenzene, 3.4-bis[3-(4-chlorophenoxycarbonyl)-2-thioureido]-toluene, 1.2-bis[3-(2-naphthoxycarbonyl)-2-thioureido]benzene and 1.2-bis[3-(2-naphthoxycarbonyl)-2-thioureido]-4'-nitrobenzene.
Claim 4
Dependent Claim
14 words
2-bis(3-benzyloxycarbonyl-2-thioureido)-benzene, 1.2-bis[3-(β-methoxy) ethoxycarbonyl-2-thioureido]benzene, 1.2-bis]3-(β-chloroethoxycarbonyl)-2-thioureido]benzene, 1.2-bis(3-allyloxycarbonyl-2-thioureido)benzene, 1.2-bis[3-(2-propynyloxycarbonyl)-2-thioureido] benzene, 1.2-bis[3-(4-chlorophenoxycarbonyl)-2-thioureido]benzene, 1.2-bis[3-(4-nitrophenoxycarbonyl)-2-thioureido]benzene, 1.2-bis[3-(4-methylphenoxycarbonyl)-2-thioureido]-4-chlorobenzene, 3.4-bis[3-(4-chlorophenoxycarbonyl)-2-thioureido]-toluene, 1.2-bis[3-(2-naphthoxycarbonyl)-2-thioureido]benzene and 1.2-bis[3-(2-naphthoxycarbonyl)-2-thioureido]-4'-nitrobenzene.
Claim 5
Dependent Claim
19 words
A method for the treatment of helminth infections according to claim 1 wherein the benzene derivative is administered orally.
Claim 6
Dependent Claim
44 words
A method for the treatment of helminth infection in domestic animals according to claim 1 in which the benzene derivative is administered orally and wherein the dosage of the benzene derivative is from about 0.1 to 1000 mg. per Kg. of normal body weight.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-05-18 | 1979-11-17 | 1980-05-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-05-18 | 1983-11-17 | 1984-05-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-05-18 | 1987-11-17 | 1988-05-18 | $7700.00 | Window Closed / Lapsed |