US3954729A
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Process for preparing a thiolcarbamate
Assignee: Ihara Chemical Industry Co Ltd
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Filing: 1974-03-25
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Granted: 1976-05-04
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Expires: 1994-03-25
Abstract
Abstract Thiolcarbamates are prepared by reacting a secondary amine having the formula R1 ANGLE NH R2 wherein R1 and R2 are the same or different and each represent hydrogen, lower alkyl, alkoxy, alkenyl, alkoxyalkyl, cycloalkyl, hydroxyalkyl, benzyl or phenyl or R1 and R2 combined is a nitrogen containing heterocyclic ring with carbonylsulfide to form an intermediate of an amine salt of a thiolcarbamic acid having the formula R1O<-> R1<+> PARALLEL ANGLE N-C-S NH2 ANGLE , R2 R2 wherein R1 and R2 are defined as above, in an organic solvent having the formula WHEREIN N IS 0, 1 OR 2 AND R' is hydrogen, halogen or a lower alkyl group which solvent is sparingly soluble or insoluble in water and which dissolves the amine salt of the thiolcarbonic acid, and then reacting the intermediate with an alkyl halide having the formula X - CH2 - R3 wherein X represents halogen, and R3 represents hydrogen, lower alkyl or naphthyl or phenyl which can be substituted with halogen, alkyl, alkoxy, alkylthio, cyano or nitro, to yield a thiolcarbamate having the formula R1O PARALLEL ANGLE N-C-S-CH2-R3. R2
Inventors
- 👤 Zenichi Sato
- 👤 Keiichiro Takagi
- 👤 Masamichi Shimizu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 05:53
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/16; C07D295/20; C07D295/21
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
202 words
In a process for preparing a thiolcarbamate by reacting a secondary amine having the formula ##EQU11## wherein R 1 and R 2 are the same or different and each represent hydrogen, lower alkyl, alkoxy, alkenyl, alkoxyalkyl, cycloalkyl, hydroxyalkyl, benzyl or phenyl, or R 1 R 2 combined is a nitrogen containing heterocyclic ring with carbonylsulfide to form an intermediate of an amine salt of a thiolcarbamic acid having the formula: ##EQU12## wherein R 1 and R 2 are defined as above, and then reacting the intermediate with an alkyl halide having the formula X -- CH.sub.2 -- R.sub.3 wherein X represents halogen, and R 3 represents hydrogen, lower alkyl, or naphthyl or phenyl which can be substituted with halogen, alkyl, alkoxy, alkylthio, cyano or nitro to yield a thiolcarbamate having the formula ##EQU13## the improvement which comprises reacting said amine in a solution of an organic solvent having the formula ##SPC6## wherein n is 0, 1 or 2 and R' represents hydrogen, halogen or lower alkyl, which solvent is sparingly soluble or insoluble in water and which dissolves the amine salt of the thiolcarbamic acid, wherein less than 0.48 mole of carbonyl-sulfide per mole of the amine is added to the reaction.
Claim 2
Dependent Claim
202 words
In a process for preparing a thiolcarbamate by reacting a secondary amine having the formula ##EQU11## wherein R 1 and R 2 are the same or different and each represent hydrogen, lower alkyl, alkoxy, alkenyl, alkoxyalkyl, cycloalkyl, hydroxyalkyl, benzyl or phenyl, or R 1 R 2 combined is a nitrogen containing heterocyclic ring with carbonylsulfide to form an intermediate of an amine salt of a thiolcarbamic acid having the formula: ##EQU12## wherein R 1 and R 2 are defined as above, and then reacting the intermediate with an alkyl halide having the formula X -- CH.sub.2 -- R.sub.3 wherein X represents halogen, and R 3 represents hydrogen, lower alkyl, or naphthyl or phenyl which can be substituted with halogen, alkyl, alkoxy, alkylthio, cyano or nitro to yield a thiolcarbamate having the formula ##EQU13## the improvement which comprises reacting said amine in a solution of an organic solvent having the formula ##SPC6## wherein n is 0, 1 or 2 and R' represents hydrogen, halogen or lower alkyl, which solvent is sparingly soluble or insoluble in water and which dissolves the amine salt of the thiolcarbamic acid, wherein less than 0.48 mole of carbonyl-sulfide per mole of the amine is added to the reaction.
Claim 3
Dependent Claim
40 words
The process of claim 1, wherein 0.48 mole - 0.10 mole of carbonylsulfide is reacted per mole of the amine, and the unreacted amine is recovered after reacting the intermediate in the presence of the amine with the alkyl halide.
Claim 4
Dependent Claim
27 words
The process of claim 1, wherein the reaction of the intermediate in the presence of the amine with the alkyl halide is performed at 0° - 60°C.
Claim 5
Dependent Claim
39 words
The process of claim 1, wherein the organic solvent is dichlorobenzene, benzene, toluene or xylene, and the amine is dimethylamine, diethylamine, di-n-propylamine, di-iso-propylamine, di-n-butylamine, di-iso-butylamine, diamylamine, bis(2-ethylhexyl)amine, diallylamine, methylethylamine, methylbutylamine, methylphenylamine, ethylphenylamine, bis(2-hydroxyethyl)amine, dibenzylamine, pyrrolidine, piperidine, morpholine or hexylimine.
Claim 6
Dependent Claim
55 words
The process of claim 1, wherein carbonylsulfide is introduced into a solution of diethyl amine in the organic solvent in a molar ratio based on the diethylamine of less than 0.48 and then p-chlorobenzyl halide is added to the reaction mixture containing free diethylamine at 0° - 60°C resulting in the formation of S-(p-chlorobenzyl)-N,N-diethyl thiolcarbamate.
Claim 7
Dependent Claim
56 words
The process of claim 1, wherein carbonylsulfide in introduced into a solution of dimethylamine in the organic solvent in a molar ratio based on the dimethylamine of less than 0.48, and then 2,5-dimethyl benzyl halide is added to the reaction mixture containing free dimethylamine at 0° - 60°C resulting in the formation of S-(2,5-dimethyl benzyl)N,N-dimethyl thiolcarbamate.
Claim 8
Dependent Claim
53 words
The process of claim 1, wherein carbonylsulfide is introduced into a solution of hexylimine in the organic solvent in a molar ratio based on the hexylimine of less than 0.48, and then ethyl halide is added to the reaction mixture containing free hexylimine at 0°- 60°C resulting in the formation of S-ethyl-N,N-hexamethylene thiolcarbamate.
Claim 9
Dependent Claim
54 words
The process of claim 1, wherein carbonylsulfide is introduced into a solution of dimethylamine in the organic solvent in a molar ratio based on the dimethylamine of less than 0.48, and then β-naphthylmethyl halide is added to the reaction mixture containing free dimethylamine at 0° - 60°C resulting in the formation of S-(β-naphthylmethyl)-N,N-dimethyl thiolcarbamate.
References Cited (Backward Citations)
US3167571A
Cited
US3151119A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-05-04 | 1979-11-03 | 1980-05-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-05-04 | 1983-11-03 | 1984-05-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-05-04 | 1987-11-03 | 1988-05-04 | $7700.00 | Window Closed / Lapsed |