US3952013A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-Thiachromone-2-carboxylic acids and derivatives
Assignee: Fisons Ltd
•
Filing: 1974-03-27
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Granted: 1976-04-20
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Expires: 1994-03-27
Abstract
Abstract Pharmaceutical compounds of formula I, ##SPC1## in which P, q, r, and T, which may be the same or different, each represent hydrogen, an alkyl, hydroxy, alkoxy, hydroxyalkoxy, alkoxyalkoxy, acetoxy, carboxy, amino, alkylamino, dialkylamino, alkenyl, p-toluenesulphonyloxy, aralkyl, phenyl, nitro, carboxy ester, alkenyloxy or acyl group, none of which groups contain more than 10 carbon atoms or an adjacent pair of P, Q, R and T, together with the adjacent carbon atoms in the benzene ring may form a fused 5 or 6 membered carbocyclic or oxygen containing heterocyclic ring, and V and W, which are different, each represent oxygen or sulphur.
Inventors
- 👤 Richard Hazard
- 👤 John King
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 19:17
CPC Classifications
C; C07; C07D; C07D335/00; C07D335/04; C07D335/06; C07D311/00; C07D311/02; C07D311/04; C07D311/22; C07D311/24; C07F; C07F1/00; C07F1/005
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
121 words
A member selected from the group consisting of a compound of the formula ##SPC10## wherein P, Q, R, and T are the same or different and each represents hydrogen, alkyl, hydroxy, alkoxy, hydroxyalkoxy, alkoxyalkoxy, acetoxy, carboxy, amino, alkylamino, dialkylaminio, alkenyl, p-toluenesulfonyloxy, phenylalkyl, phenyl, nitro, carboxy ester derived from an alkanol of 1 to 6 carbon atoms, alkenyloxy, alkanoyl, none of which groups contain more tha 10 carbon atoms, or an adjacent pair of P, Q, R, and T form the chain --CH=CH--CH=CH--, with the provisos that i. not all of P, Q, R and T are hydrogen, and ii. when T is methoxy and Q and R are hydrogen, P is not a methyl group, and a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
121 words
A member selected from the group consisting of a compound of the formula ##SPC10## wherein P, Q, R, and T are the same or different and each represents hydrogen, alkyl, hydroxy, alkoxy, hydroxyalkoxy, alkoxyalkoxy, acetoxy, carboxy, amino, alkylamino, dialkylaminio, alkenyl, p-toluenesulfonyloxy, phenylalkyl, phenyl, nitro, carboxy ester derived from an alkanol of 1 to 6 carbon atoms, alkenyloxy, alkanoyl, none of which groups contain more tha 10 carbon atoms, or an adjacent pair of P, Q, R, and T form the chain --CH=CH--CH=CH--, with the provisos that i. not all of P, Q, R and T are hydrogen, and ii. when T is methoxy and Q and R are hydrogen, P is not a methyl group, and a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
63 words
A compound according to claim 1 in which P, Q, R and T which may be the same or different, each represent hydrogen, an alkyl, hydroxy, alkoxy, hydroxyalkoxy, alkoxy-alkoxy, amino, alkylamino, dialkylamino, alkenyl, p-toluenesulphonyloxy, phenylalkyl, phenyl, nitro, carboxy ester group derived from an alkanol of 1 to 6 carbon atoms, or alkenyloxy groups none of which groups contain more than 10 carbon atoms.
Claim 4
Dependent Claim
42 words
A compound according to claim 1 in which P, Q, R and T, which may be the same or different, are hydrogen, hydroxyalkoxy, alkoxy-alkoxy, alkoxy, phenyl, alkyl, nitro, hydroxy, p-toluenesulphonyloxy or alkenyloxy none of which groups contain more than 10 carbon atoms.
Claim 5
Dependent Claim
26 words
A compound according to claim 1 in which P, Q, R and T represent hydrogen, methoxy, ethoxy, phenyl, allyloxy, isoamyloxy, methyl, propyl, t-butyl, p-toluenesulphonyloxy, or nitro.
Claim 6
Dependent Claim
10 words
A compound according to claim 1 which is 6-(2-Hydroxypropoxy)-1-thiachromone-2-carboxylic acid.
Claim 7
Dependent Claim
10 words
A compound according to claim 1 which is 6-(2-Ethoxyethoxy)-1-thiachromone-2-carboxylic acid.
Claim 8
Dependent Claim
10 words
A compound according to claim 1 which is 6-Ethoxy-1-thiachromone-2-carboxylic acid.
Claim 9
Dependent Claim
10 words
A compound according to claim 1 which is 5,8-Dimethoxy-1-thiachromone-2-carboxylic acid.
Claim 10
Dependent Claim
10 words
A compound according to claim 1 which is 5,8-Diethoxy-1-thiachromone-2-carboxylic acid.
Claim 11
Dependent Claim
10 words
A compound according to claim 1 which is 5:6-benzo-1-thiachromone-2-carboxylic acid.
Claim 12
Dependent Claim
11 words
A compound according to claim 1 which is 6-Phenyl-1-thiachromone 2-carboxylic acid.
Claim 13
Dependent Claim
10 words
A compound according to claim 1 which is 6-Methyl-1-thiachromone-2-carboxylic acid.
Claim 14
Dependent Claim
10 words
A compound according to claim 1 which is 6-Nitro-1-thiachromone-2-carboxylic acid.
Claim 15
Dependent Claim
10 words
A compound according to claim 1 which is 1-Thiachromone-2,8-dicarboxylic acid.
Claim 16
Dependent Claim
10 words
A compound according to claim 1 which is 6-Hydroxy-1-thiachromone-2-carboxylic acid.
Claim 17
Dependent Claim
11 words
A compound according to claim 1 which is 6-Allyloxy-1 -thiachromone-2-carboxylic acid.
Claim 18
Dependent Claim
10 words
A compound according to claim 1 which is 6,8-Di-isopropyl-1-thiachromone-2-carboxylic acid.
Claim 19
Dependent Claim
10 words
A compound according to claim 1 which is 6-(3-Methoxybutoxy)=1-thiachromone-2-carboxylic acid.
Claim 20
Dependent Claim
10 words
A compound according to claim 1 which is 5-(3-Methoxybutoxy)-8-propyl-1-thiachromone-2-carboxylic acid.
Claim 21
Dependent Claim
10 words
A compound according to claim 1 which is 5-(3-Methylbutoxy)-8-methyl-1-thiachromone-2-carboxylic acid.
Claim 22
Dependent Claim
10 words
A compound according to claim 1 which is 6,8-Di-t-butyl-1-thiachromone-2-carboxylic acid.
Claim 23
Dependent Claim
10 words
A compound according to claim 1 which is 8-Methyl-5-isopropyl-1-thiachromone-2-carboxylic acid.
Claim 24
Dependent Claim
10 words
A compound according to claim 1 which is 6-t-butyl-1-thiachromone-2-carboxylic acid.
Claim 25
Dependent Claim
10 words
A compound according to claim 1 which is 6-p-toluenesulphonyloxy-1-thiachromone-2-carboxylic acid.
References Cited (Backward Citations)
US2923716A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-04-20 | 1979-10-20 | 1980-04-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-04-20 | 1983-10-20 | 1984-04-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-04-20 | 1987-10-20 | 1988-04-20 | $7700.00 | Window Closed / Lapsed |