US3950537A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Gastrointestinally active thioureas
Assignee: Rohm and Haas Co
•
Filing: 1975-02-26
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Granted: 1976-04-13
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Expires: 1995-02-26
Abstract
Abstract Thioureas of the general structure ArylNHC(S)-NR1R2 are useful as antidiarrheal, antimotility or antisecretory agents. Particularly useful are those wherein Aryl is 2-methylphenyl and NR1R2 is NHCH2CH2OH.
Inventors
- 👤 Peter L. De Benneville
- 👤 Jack N. Moss
- 👤 Esam Z. Dajani
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 05:04
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/17
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
57 words
A method for treating a mammal suffering from gastrointestinal disturbances which comprises administering to said mammal in an amount effective to reduce gastrointestinal motility and diarrhea, a compound of the formula: ##EQU5## wherein X 1 is methyl or ethyl; X 2 is 3,4 or 6-methyl; 3,4 or 5-chloro or bromo and n is an integer of 0-2.
Claim 2
Independent Claim
57 words
A method for treating a mammal suffering from gastrointestinal disturbances which comprises administering to said mammal in an amount effective to reduce gastrointestinal motility and diarrhea, a compound of the formula: ##EQU5## wherein X 1 is methyl or ethyl; X 2 is 3,4 or 6-methyl; 3,4 or 5-chloro or bromo and n is an integer of 0-2.
Claim 3
Dependent Claim
11 words
A method according to claim 1 wherein the compound is 1-(2-ethylphenyl)-3-(2-hydroxyethyl)thiourea.
Claim 4
Dependent Claim
11 words
A method according to claim 1 wherein the compound is 1-(2,3-dimethylphenyl)-3-(2-hydroxyethyl)thiourea.
Claim 5
Dependent Claim
11 words
A method according to claim 1 wherein the compound is 1-(2-methyl-4-chlorophenyl)-3-(2-hydroxyethyl)thiourea.
Claim 6
Dependent Claim
11 words
A method according to claim 1 wherein the compound is 1-(2-methyl-4-bromophenyl-3-(2-hydroxyethyl)thiourea,
Claim 7
Dependent Claim
11 words
A method according to claim 1 wherein the compound is 1-(2,4,6-trimethylphenyl)-3-(2-hydroxyethyl)thiourea.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-04-13 | 1979-10-13 | 1980-04-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-04-13 | 1983-10-13 | 1984-04-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-04-13 | 1987-10-13 | 1988-04-13 | $7700.00 | Window Closed / Lapsed |