US3950327A
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New nitrones, their manufacture and their use for the manufacture of n-substituted araliphatic aldehyde-nitrones
Assignee: Novartis Corp
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Filing: 1974-07-24
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Granted: 1976-04-13
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Expires: 1994-07-24
Abstract
Abstract α-Halogen-nitrones of the formula ##EQU1## wherein Hal is a bromine or preferably a chlorine atom, R 1 represents a cycloalkyl or an alkyl radical and R 2 is hydrogen or an organic radical. Use as intermediates especially for the substitution of a hydrogen atom in aromatic compounds by the radical ##EQU2##
Inventors
- 👤 Albert Eschenmoser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 13:29
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/77; C07D307/78; C07D307/79; C07D307/80; C07C; C07C291/00; C07C291/02; C07C45/00; C07C45/51; C07C45/516; C07C45/54; C07C47/00; C07C47/20; C07C47/228; C07C47/277; C07C51/00; C07C51/16
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
115 words
A process for preparing nitrones of the general formula ##EQU9## wherein R represents a member selected from the group of thiophenyl, furyl, benzofuryl, N-lower alkyl- or N-lower alkanoyl-pyrryl or -benzopyrryl, toluyl. cresyl, dimethoxyphenyl, dimethylphenyl, acetylaminophenyl, indanyl, naphthyl and its lower alkyl, lower alkoxy or lower alkanoylamino derivatives, phenanthryl and oestronyl, R 1 denotes 5 or 6 ringmembered cycloalkyl or lower alkyl and R 2 denotes hydrogen or lower alkyl, phenyl or phenyl-lower alkyl, which comprises reacting the compounds of the formulae R--h and ##EQU10## wherein Hal represents chloro or bromo and R 1 and R 2 have the abovementioned meaning, in the presence of silver ions and a solvent at a temperature below 50° C.
Claim 2
Dependent Claim
115 words
A process for preparing nitrones of the general formula ##EQU9## wherein R represents a member selected from the group of thiophenyl, furyl, benzofuryl, N-lower alkyl- or N-lower alkanoyl-pyrryl or -benzopyrryl, toluyl. cresyl, dimethoxyphenyl, dimethylphenyl, acetylaminophenyl, indanyl, naphthyl and its lower alkyl, lower alkoxy or lower alkanoylamino derivatives, phenanthryl and oestronyl, R 1 denotes 5 or 6 ringmembered cycloalkyl or lower alkyl and R 2 denotes hydrogen or lower alkyl, phenyl or phenyl-lower alkyl, which comprises reacting the compounds of the formulae R--h and ##EQU10## wherein Hal represents chloro or bromo and R 1 and R 2 have the abovementioned meaning, in the presence of silver ions and a solvent at a temperature below 50° C.
Claim 3
Dependent Claim
21 words
Process according to claim 1, wherein the silver ions used are ions of salts of which the anions are weakly nucleophilic.
Claim 4
Dependent Claim
14 words
Process according to claim 1, wherein the silver ions are derived from silver tetrafluoborate.
Claim 5
Dependent Claim
20 words
Process according to claim 1, wherein sulphur dioxide or nitromethane or a halogenated lower hydrocarbon is used as the solvent.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-04-13 | 1979-10-13 | 1980-04-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-04-13 | 1983-10-13 | 1984-04-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-04-13 | 1987-10-13 | 1988-04-13 | $7700.00 | Window Closed / Lapsed |