US3950135A
Expired / Lapsed
US
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Method of sepctral analysis using nmr shift reagents
Assignee: Massachusetts Institute of Technology
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Filing: 1974-07-24
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Granted: 1976-04-13
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Expires: 1994-07-24
Abstract
Abstract The ability of nuclear magnetic resonance spectroscopy to distinguish between compounds and between parts of compounds is substantially increased by the use of certain rare earth chelate shift reagents. The preferred shift reagents are the europium III chelates of substituted or unsubstituted dicampholyl ligands, and europium III chelates of substituted or unsubstituted nopinato compounds. The reagents are particularly useful in determining the enantiomeric purity of compositions containing mixtures of enantiomers.
Inventors
- 👤 George M. Whitesides
- 👤 Michael McCreary
- 👤 Daniel Lewis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 16:19
CPC Classifications
C; C07; C07F; C07F5/00; C07F5/003; C07C; C07C45/00; C07C45/45; C07C45/455; C07C49/00; C07C49/29; C07C49/297; C07C49/313; C07C49/92; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
74 words
A method of spectral analysis of a composition containing at least one organic compound comprising adding a shift reagent to said composition, said shift reagent being a lanthanide chelate of a ligand selected from d,d-dicampholylmethane, 1,1-dicampholylmethane, and a compound of the formula: ##SPC2## wherein R is hydrogen, alkyl, halogenated alkyl or aryl and Me is a paramagnetic trivalent rare earth ion, and measuring the nuclear magnetic spectrum of said composition containing said shift reagent.
Claim 2
Independent Claim
74 words
A method of spectral analysis of a composition containing at least one organic compound comprising adding a shift reagent to said composition, said shift reagent being a lanthanide chelate of a ligand selected from d,d-dicampholylmethane, 1,1-dicampholylmethane, and a compound of the formula: ##SPC2## wherein R is hydrogen, alkyl, halogenated alkyl or aryl and Me is a paramagnetic trivalent rare earth ion, and measuring the nuclear magnetic spectrum of said composition containing said shift reagent.
Claim 3
Dependent Claim
15 words
The method of claim 1, wherein said shift reagent is a lanthanide chelate of d,d-dicampholylmethane.
Claim 4
Dependent Claim
15 words
The method of claim 2, wherein said shift reagent is a lanthanide chelate of 1,1-dicampholylmethane.
Claim 5
Dependent Claim
18 words
The method of claim 1, wherein R is selected from hydrogen, lower alkyl, halogenated lower alkyl, and phenyl.
Claim 6
Dependent Claim
26 words
The method of claim 1, wherein R is the formula --C n F 2n +1 , where n is a whole number from 1 to 10.
Claim 7
Dependent Claim
12 words
The method of claim 5, wherein n is from 1 to 4.
Claim 8
Dependent Claim
14 words
The method of claim 1, wheren said organic compound is an optically active compound.
Claim 9
Dependent Claim
15 words
The method of claim 1, wherein said composition contains a mixture of optically active compounds.
Claim 10
Dependent Claim
12 words
The method of claim 1, wheren Me is a trivalent europium ion.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-04-13 | 1979-10-13 | 1980-04-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-04-13 | 1983-10-13 | 1984-04-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-04-13 | 1987-10-13 | 1988-04-13 | $7700.00 | Window Closed / Lapsed |