US3947587A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Analgesics obtained by reacting a primary amine and an aldehyde
Assignee: Cortial SA
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Filing: 1973-01-26
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Granted: 1976-03-30
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Expires: 1993-01-26
Abstract
Abstract Products having analgesic and antipyretic activity are provided having the formula: R -- Z -- R' in which each of R and R', which may be the same or different, represents a phenyl or pyridyl radical which is optionally substituted by at least one substituent selected from a halogen atom, --NO 2 , --CONH 2 --, --OC 2 H 5 , OCH 3 , --CH 3 , --COOC 2 H 5 , --COOCH 3 , --COOH and --OCH 2 --COOH radical; Z represents a radical selected from --CH=N-- and >CH--NH-- in which the radical >CH-- of said amino group forms part of a heterocyclic structure of the formula: ##EQU1## in which the two carbon atoms connected by a double bond form part of the radical R or R'. Specific compounds include 2-(2'-carboxamido-anilino)-o-phthalide and 2-(2' or 4'-ethoxy-anilino)-o-phthalide.
Inventors
- 👤 Georges Negrevergne
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 16:07
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/44; C07D213/53; A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/34; C07D213/60; C07D213/78; C07D213/79; C07D307/00; C07D307/77; C07D307/87
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
142 words
A pharmaceutical composition having analgesic, anti-inflammatory, and anti-pyretic activity which comprises, as the active ingredient, an analgesic, anti-inflammatory and anti-pyretic effective amount of at least one compound selected from the group consisting of compounds of the formula R--Z--R', in which each of R and R', which may be the same or different, represents a phenyl radical which is optionally substituted by at least one substituent selected from a halogen atom, --OC 2 H 5 , --OCH 3 , --CH 3 , --COOC 2 H 5 , --COOCH 3 , and --COOH radical; and Z represents CH--NH-- in which the radical CH-- of said amino group forms part of a heterocyclic structure of the formula ##EQU5## in which the two carbon atoms, connected by a double bond, form part of the radical R or R' in association with a pharmaceutically acceptable carrier material.
Claim 2
Dependent Claim
142 words
A pharmaceutical composition having analgesic, anti-inflammatory, and anti-pyretic activity which comprises, as the active ingredient, an analgesic, anti-inflammatory and anti-pyretic effective amount of at least one compound selected from the group consisting of compounds of the formula R--Z--R', in which each of R and R', which may be the same or different, represents a phenyl radical which is optionally substituted by at least one substituent selected from a halogen atom, --OC 2 H 5 , --OCH 3 , --CH 3 , --COOC 2 H 5 , --COOCH 3 , and --COOH radical; and Z represents CH--NH-- in which the radical CH-- of said amino group forms part of a heterocyclic structure of the formula ##EQU5## in which the two carbon atoms, connected by a double bond, form part of the radical R or R' in association with a pharmaceutically acceptable carrier material.
Claim 3
Dependent Claim
18 words
A composition according to claim 1 which contains from 0.1-1 gram per unit dose of said active ingredient.
Claim 4
Dependent Claim
35 words
A pharmaceutical composition according to claim 1 wherein R and R' are unsubstituted phenyl or phenyl substituted by at least one --Cl, --COOH, --COOCH 3 , --CH 3 , or --OC 2 H 5 radical.
Claim 5
Dependent Claim
48 words
A pharmaceutical composition having an analgesic, anti-inflammatory, and anti-pyretic activity which comprises, as the active ingredient, an analgesic, anti-inflammatory, and anti-pyretic effective amount of at least one compound selected from the group consisting of 2-(2'-carboxamido-anilino)-o-phthalide; 2-(2',6'-dichloroanilino)-o-phthalide; 2-(2',4'-dimethyl-anilino)-o-phthalide; 2-(2'-ethoxy-anilino)-o-phthalide; and 2-(4'-ethoxy-anilino)-o-phthalide in association with a pharmaceutically acceptable carrier material.
Claim 6
Dependent Claim
48 words
A pharmaceutical composition having an analgesic, anti-inflammatory, and anti-pyretic activity which comprises, as the active ingredient, an analgesic, anti-inflammatory, and anti-pyretic effective amount of at least one compound selected from the group consisting of 2-(2'-carboxamido-anilino)-o-phthalide; 2-(2',6'-dichloroanilino)-o-phthalide; 2-(2',4'-dimethyl-anilino)-o-phthalide; 2-(2'-ethoxy-anilino)-o-phthalide; and 2-(4'-ethoxy-anilino)-o-phthalide in association with a pharmaceutically acceptable carrier material.
References Cited (Backward Citations)
US3467675A
Cited
US3523124A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-03-30 | 1979-09-29 | 1980-03-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-03-30 | 1983-09-29 | 1984-03-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-03-30 | 1987-09-29 | 1988-03-30 | $7700.00 | Window Closed / Lapsed |