US3947575A
Expired / Lapsed
US
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Peptides as argiotensin converting enzyme inhibitors
Assignee: ER Squibb and Sons LLC
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Filing: 1974-06-21
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Granted: 1976-03-30
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Expires: 1994-06-21
Abstract
Abstract Disclosed herein is a process for the utilization of certain peptides as angiotensin converting enzyme inhibitors.
Inventors
- 👤 Miguel A. Ondetti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 08:29
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/56; A61K35/58; C; C07; C07K; C07K14/00; C07K14/81; C07K14/8103
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
26 words
A method of inhibiting the enzymatic conversion of angiotensin I into angiotensin II which comprises contacting angiotensin I with an effective amount of the nonapeptide L-pyroglutamyl-L-tryptophyl-L-prolyl-L-arginyl-L-prolyl-L-glutaminyl-L-isoleucyl-L-prolyl-L-proline.
Claim 2
Independent Claim
26 words
A method of inhibiting the enzymatic conversion of angiotensin I into angiotensin II which comprises contacting angiotensin I with an effective amount of the nonapeptide L-pyroglutamyl-L-tryptophyl-L-prolyl-L-arginyl-L-prolyl-L-glutaminyl-L-isoleucyl-L-prolyl-L-proline.
Claim 3
Dependent Claim
20 words
A method according to claim 1 wherein the concentration of the nonapeptide is from about 0.05 to about 10 μg/ml.
Claim 4
Independent Claim
31 words
A method of inhibiting the hypertensive effect of angiotensin I in mammalian species which comprises administering by injection to the mammal from about 0.025 mg/kg to about 4 mg/kg of L-pyroglutamyl-L-tryptophyl-L-prolyl-L-arginyl-L-prolyl-L-glutaminyl-L-isoleucyl-L-prolyl-L-proline.
Claim 5
Independent Claim
31 words
A method of inhibiting the hypertensive effect of angiotensin I in mammalian species which comprises administering by injection to the mammal from about 0.025 mg/kg to about 4 mg/kg of L-pyroglutamyl-L-tryptophyl-L-prolyl-L-arginyl-L-prolyl-L-glutaminyl-L-isoleucyl-L-prolyl-L-proline.
Claim 6
Dependent Claim
19 words
Lyophilized L-pyroglutamyl-L-tryptophyl-L-prolyl-L-arginyl-L-prolyl-L-glutaminyl-L-isoleucyl-L-prolyl-L-proline reconstituted with water or saline for injection in mammals to inhibit the hypertensive effect of angiotensin I.
Claim 7
Dependent Claim
19 words
Lyophilized L-pyroglutamyl-L-tryptophyl-L-prolyl-L-arginyl-L-prolyl-L-glutaminyl-L-isoleucyl-L-prolyl-L-proline reconstituted with water or saline for injection in mammals to inhibit the hypertensive effect of angiotensin I.
Claim 8
Dependent Claim
34 words
A sterile injectable solution for use in inhibiting the hypertensive effect of angiotensin I, comprising the nonapeptide L-pryroglutamyl-L-tryptophyl-L-prolyl-L-arginyl-L-prolyl-L-glutaminyl-L-isoleucyl-L-prolyl-L-proline and water for injection or saline in a concentration at least sufficient to dissolve the nonapeptide.
Claim 9
Dependent Claim
34 words
A sterile injectable solution for use in inhibiting the hypertensive effect of angiotensin I, comprising the nonapeptide L-pryroglutamyl-L-tryptophyl-L-prolyl-L-arginyl-L-prolyl-L-glutaminyl-L-isoleucyl-L-prolyl-L-proline and water for injection or saline in a concentration at least sufficient to dissolve the nonapeptide.
References Cited (Backward Citations)
US3819831A
Cited
US3832337A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-03-30 | 1979-09-29 | 1980-03-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-03-30 | 1983-09-29 | 1984-03-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-03-30 | 1987-09-29 | 1988-03-30 | $7700.00 | Window Closed / Lapsed |