US3947491A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stabilized choline salicylate compounds
Assignee: Purdue Frederick Co
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Filing: 1974-09-03
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Granted: 1976-03-30
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Expires: 1994-09-03
Abstract
Abstract Choline salicylate sulfite and choline salicylate alkali metal sulfite-containing compounds of the formula, ##SPC1## Wherein Me represents the sodium, potassium or lithium ion and R represents the sulfite, bisulfite, metabisulfite, dithionate, hydrosulfite and hyposulfite groups are described. Said compounds are stable and inhibit the formation of color in pharmaceutical preparations containing the same. The method for the preparation of choline salicylate sulfite and choline salicylate alkali metal sulfite-containing compounds, and pharmaceutical dosage forms containing the same are disclosed together with a method for their use to inhibit color formation.
Inventors
- 👤 William Kelly, deceased
- 👤 representative by Monica Kelly
- 👤 representative by John Kelly
- 👤 Alfred Halpern
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:22
CPC Classifications
C; C07; C07C; C07C215/00; C07C215/02; C07C215/40; C07C215/74; C07C215/90
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
24 words
A choline salicylate salt-sulfite-complex compound selected from the group consisting of choline salicylate sodium sulfite, choline salicylate potassium sulfite and choline salicylate lithium sulfite.
Claim 2
Dependent Claim
24 words
A choline salicylate salt-sulfite-complex compound selected from the group consisting of choline salicylate sodium sulfite, choline salicylate potassium sulfite and choline salicylate lithium sulfite.
Claim 3
Dependent Claim
12 words
The compound of claim 1 said compound being choline salicylate sodium sulfite.
Claim 4
Dependent Claim
12 words
The compound of claim 1 said compound being choline salicylate potassium sulfite.
Claim 5
Dependent Claim
12 words
The compound of claim 1 said compound being choline salicylate lithium sulfite.
Claim 6
Independent Claim
79 words
The method for the preparation of a choline salicylate salt-sulfite-complex compound selected from the group consisting of choline salicylate sodium sulfite, choline salicylate potassium sulfite, and choline salicylate lithium sulfite comprising: a. adding a sulfite-containing compound selected from the group consisting of sodium sulfite, potassium sulfite and lithium sulfite to an equimolecular quantity of choline salicylate, b. mixing the same, c. allowing to stand for at least one-half hour, and d. recovering the formed choline salicylate salt-sulfite-complex compound therefrom.
Claim 7
Independent Claim
79 words
The method for the preparation of a choline salicylate salt-sulfite-complex compound selected from the group consisting of choline salicylate sodium sulfite, choline salicylate potassium sulfite, and choline salicylate lithium sulfite comprising: a. adding a sulfite-containing compound selected from the group consisting of sodium sulfite, potassium sulfite and lithium sulfite to an equimolecular quantity of choline salicylate, b. mixing the same, c. allowing to stand for at least one-half hour, and d. recovering the formed choline salicylate salt-sulfite-complex compound therefrom.
Claim 8
Independent Claim
116 words
The method for the preparation of a choline salicylate salt-sulfite-complex compound selected from the group consisting of choline salicylate sodium sulfite, choline salicylate potassium sulfite and choline salicylate lithium sulfite comprising the steps of: a. dissolving a choline compound selected from the group consisting of choline, choline carbonate and choline bicarbonate in an aqueous solvent, b. adding a molecular equivalent quantity of the sulfite-containing compound selected from the group consisting of sodium sulfite, potassium sulfite and lithium sulfite, c. adding an equimolar quantity of salicylic acid, d. maintaining the pH between pH 4.5 and pH 7, e. stirring and warming to not more than 50° C, and, f. recovering the formed choline salicylate salt-sulfite-complex compound therefrom.
Claim 9
Independent Claim
116 words
The method for the preparation of a choline salicylate salt-sulfite-complex compound selected from the group consisting of choline salicylate sodium sulfite, choline salicylate potassium sulfite and choline salicylate lithium sulfite comprising the steps of: a. dissolving a choline compound selected from the group consisting of choline, choline carbonate and choline bicarbonate in an aqueous solvent, b. adding a molecular equivalent quantity of the sulfite-containing compound selected from the group consisting of sodium sulfite, potassium sulfite and lithium sulfite, c. adding an equimolar quantity of salicylic acid, d. maintaining the pH between pH 4.5 and pH 7, e. stirring and warming to not more than 50° C, and, f. recovering the formed choline salicylate salt-sulfite-complex compound therefrom.
References Cited (Backward Citations)
US3069321A
Cited
US3326760A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-03-30 | 1979-09-29 | 1980-03-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-03-30 | 1983-09-29 | 1984-03-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-03-30 | 1987-09-29 | 1988-03-30 | $7700.00 | Window Closed / Lapsed |