US3943119A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tuberculin active proteins and peptides from the cells of tubercle bacilli
Assignee: Mitsui Pharmaceuticals Inc
•
Filing: 1974-03-28
•
Granted: 1976-03-09
•
Expires: 1994-03-28
Abstract
Abstract Tuberculin active simple proteins and peptides which have the following peptide linkage --Asn--Gly--Ser--Gln--Met-- as a tuberculin active functional group, and a process for preparing the same from the cells of tubercle bacilli.
Inventors
- 👤 Toru Tsumita
- 👤 Seishi Kuwabara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 23:42
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/195; C07K14/35; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/863; Y10S435/866
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
68 words
A tuberculin active simple protein from Mycobacterium tuberculosis strain Aoyama B which is characterized by the following amino acid sequence: ##EQU3## wherein Asn and Gln represent asparagine residue and glutamine residue, respectively, and the remaining abbreviations represent the usual meanings and wherein the cysteine residues at positions 27 and 59 form one intra-chain disulfide bridge, said protein also being characterized by the following amino acid composition per molecule:
Claim 2
Dependent Claim
68 words
A tuberculin active simple protein from Mycobacterium tuberculosis strain Aoyama B which is characterized by the following amino acid sequence: ##EQU3## wherein Asn and Gln represent asparagine residue and glutamine residue, respectively, and the remaining abbreviations represent the usual meanings and wherein the cysteine residues at positions 27 and 59 form one intra-chain disulfide bridge, said protein also being characterized by the following amino acid composition per molecule:
Claim 3
Dependent Claim
43 words
Lys 4, His 1, Arg. 4, Cys 2, Asp 11 (containing one asparagine residue), Thr 5, Ser 4, Glu 11 (containing one glutamine residue), Pro 5, Gly 7, Ala 11, Val 8, Met 1, I1e 4, Leu 7, Tyr 2 and Phe 2.
Claim 4
Dependent Claim
43 words
Lys 4, His 1, Arg. 4, Cys 2, Asp 11 (containing one asparagine residue), Thr 5, Ser 4, Glu 11 (containing one glutamine residue), Pro 5, Gly 7, Ala 11, Val 8, Met 1, I1e 4, Leu 7, Tyr 2 and Phe 2.
Claim 5
Dependent Claim
29 words
A tuberculin active fragment which is prepared by enzymatic digestion of the tuberculin active simple protein of claim 1 and which has the following tuberculin active group therein: -Asn-Gly-Ser-Gln-Met-.
Claim 6
Dependent Claim
12 words
A tuberculin active pentapeptide whose amino acid sequence is as follows. ##EQU4##
Claim 7
Dependent Claim
12 words
A tuberculin active pentapeptide whose amino acid sequence is as follows. ##EQU4##
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-03-09 | 1979-09-08 | 1980-03-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-03-09 | 1983-09-08 | 1984-03-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-03-09 | 1987-09-08 | 1988-03-09 | $7700.00 | Window Closed / Lapsed |