Abstract Compounds of the formula ##SPC1## Wherein R 1 represents lower alkyl, cycloalkyl or phenyl which is optionally substituted by halogen, lower alkyl or lower alkoxy, and one of the groups R 2 and R 3 represents phenyl which is optionally substituted by halogen, lower alkyl, hydroxy, lower alkoxy, lower alkylthio or lower alkylsulphonyl, and the other represents a 6-membered heteroaromatic radical containing 1 or 2 ring nitrogen atoms, their N-oxides and salts, with anti-inflammatory, antinociceptive and antipyretic activity, they are active ingredients of pharmaceutical compositions and can be used for the relief and removal of pain as well as for the treatment of rheumatic, arthritic and other inflammatory complaints; an illustrative example is 2-isopropyl-4(5)-(p-methoxyphenyl)-5(4)-3-pyridyl-imidazole.
A pharmaceutical composition for treating pain in mammals comprising an effective amount of a compound of the formula ##SPC4## wherein R 1 represents isopropyl, sec.butyl, tert.butyl or p-chlorophenyl, one of the groups R 2 and R 3 represents a phenyl group or a p-methoxyphenyl, and the other represents a pyridyl group, or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutical carrier.
Claim 2
Dependent Claim
63 words
A pharmaceutical composition for treating pain in mammals comprising an effective amount of a compound of the formula ##SPC4## wherein R 1 represents isopropyl, sec.butyl, tert.butyl or p-chlorophenyl, one of the groups R 2 and R 3 represents a phenyl group or a p-methoxyphenyl, and the other represents a pyridyl group, or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutical carrier.
Claim 3
Dependent Claim
23 words
A method of treating pain in mammals which comprises administering to said mammals an effective amount of a compound according to claim 1.