Aromatic carboxylic amide derivatives
Abstract
Abstract Novel aromatic carboxylic amides of the general formula: ##EQU1## wherein each of R 1 and R 2 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, R 3 and R 4 are hydrogen atoms or together form another chemical bond, each X is a hydroxyl group, a halogen atom, an alkyl group having 1-4 carbon atoms and an alkoxy group containing 1-4 carbon atoms, and n is an integer of 1-3, with the proviso that when two Xs are alkyl or alkoxy groups, they may be connected together to form a ring, as well as pharmaceutically acceptable salts thereof. These compounds possess a strong antiallergenic action and are thus useful for treatment of asthma, hay fever, anticaria and atopic dermatitis. The above aromatic carboxylic amides can be prepared by reacting a reactive functional derivative of the general formula: ##EQU2## wherein R 1 , R 2 , R 3 , R 4 , X and n have the same meanings given above, with an aminobenzoic acid of the formula: And, if desired, converting the resulting amide into the corresponding salts.
Inventors
- 👤 Kozaburo Harita
- 👤 Yukiyoshi Ajisawa
- 👤 Kinji Iizuka
- 👤 Yukihiko Kinoshita
- 👤 Tetsuhide Kamijo
- 👤 Michihiro Kobayashi
Bibliographic Details
Claims Analysis
Total Claims: 8References Cited (Backward Citations)
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