US3940395A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4-Amino-2-phenyl-6-thiopryimidines
Assignee: Wyeth LLC
•
Filing: 1971-04-23
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Granted: 1976-02-24
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Expires: 1991-04-23
Abstract
Abstract The invention is directed to 4-amino-2-phenyl-6-thiopyrimidine compounds having the formula ##SPC1## Where R 1 -R 3 are as defined in the specification. The compounds have pharmacodynamic activity as central nervous system depressants. That is, they produce a calming effect in the host.
Inventors
- 👤 Arthur A. Santilli
- 👤 Dong H. Kim
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 18:59
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/46; C07D239/30; C07D239/52; C07D239/54
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
79 words
A compound selected from the group consisting of those having the formula: ##SPC4## wherein R 1 is selected from the group consisting of hydrogen, dichloro, halogen, methyl, ethyl, propyl and methoxy; R 2 is selected from the group consisting of amino, 4-methylpiperazino, 4-ethylpiperazino, methoxyethylamino, methoxypropylamino, 4-hydroxyethylpiperazino, hydroxyethylamino, hydroxypropylamino, hexahydroazepinyl, dimethoxyethylamino; diethyoxyethylamino, methylamino, ethylamino, propylamino and butylamino; and R 3 is selected from the group consisting of phenyl, halophenyl, ethylphenyl, methoxyphenyl, ethoxyphenyl, propoxyphenyl, benzyl, halobenzyl, methylbenzyl, methoxybenzyl, ethoxybenzyl and propoxybenzyl.
Claim 2
Dependent Claim
79 words
A compound selected from the group consisting of those having the formula: ##SPC4## wherein R 1 is selected from the group consisting of hydrogen, dichloro, halogen, methyl, ethyl, propyl and methoxy; R 2 is selected from the group consisting of amino, 4-methylpiperazino, 4-ethylpiperazino, methoxyethylamino, methoxypropylamino, 4-hydroxyethylpiperazino, hydroxyethylamino, hydroxypropylamino, hexahydroazepinyl, dimethoxyethylamino; diethyoxyethylamino, methylamino, ethylamino, propylamino and butylamino; and R 3 is selected from the group consisting of phenyl, halophenyl, ethylphenyl, methoxyphenyl, ethoxyphenyl, propoxyphenyl, benzyl, halobenzyl, methylbenzyl, methoxybenzyl, ethoxybenzyl and propoxybenzyl.
Claim 3
Dependent Claim
10 words
A compound as described in claim 1 which is: 4-amino-2-phenyl-6-phenylthiopyrimidine.
Claim 4
Dependent Claim
10 words
A compound as described in claim 1 which is 4-(4-methyl-1-piperazinyl)-2-phenyl-6-phenylthiopyrimidine.
Claim 5
Dependent Claim
10 words
A compound as described in claim 1 which is: 4-amino-2-phenyl-6-(3-tolylthio)-pyrimidine.
Claim 6
Dependent Claim
10 words
A compound as described in claim 1 which is: 4-amino-6-(4-chlorophenylthio)-2-phenylpyrimidine.
Claim 7
Dependent Claim
10 words
A compound as described in claim 1 which is: 4-(4-chlorophenylthio)-6-ethylamino-2-phenylpyrimidine.
Claim 8
Dependent Claim
10 words
A compound as described in claim 1 which is: 4-(4-chlorophenylthio)-6-(4-methyl-1-piperazinyl)-2-phenylpyrimidine.
Claim 9
Dependent Claim
10 words
A compound as described in claim 1 which is: 4-(4-chlorophenylthio-6-[2-(methoxyethyl)amino]-2-phenylpyrimidine.
Claim 10
Dependent Claim
11 words
A compound as described in claim 1 which is: 4-[4-(4-chlorophenylthio)-2-phenyl-6-pyrimidinyl]-1-piperazine ethanol.
Claim 11
Dependent Claim
10 words
A compound as described in claim 1 which is: N-[2-(6-[4-chlorophenylthio]-2-phenylpyrimidin-4-ylamino)ethyl]-acetamide.
Claim 12
Dependent Claim
10 words
A compound as described in claim 1 which is: 2-(4-chlorophenyl)-4-(4-chlorophenylthio)-6-(4-methyl-piperazin-1-yl)-pyrimidine.
Claim 13
Dependent Claim
11 words
A compound as described in claim 1 which is: 2-(4-chlorophenyl)-4-(4-chlorophenylthio)-6- [(2-methoxyethyl)-amino]-pyrimidine.
Claim 14
Dependent Claim
11 words
A compound as described in claim 1 which is: 2-(3-chlorophenyl)-4-(4-chlorophenylthio)-6-(4-methylpiperazin-1-yl)-pyrimidine, hydrochloride.
Claim 15
Dependent Claim
10 words
A compound as described in claim 1 which is: 4-(4-chlorophenylthio)-6-(4-methyl-1-piperazinyl)-2-(4-tolyl)-pyrimidine.
Claim 16
Dependent Claim
10 words
A compound as described in claim 1 which is: 4-(4-chlorophenylthio)-6-(2-methoxyethylamino)-2-(4-tolyl)pyrimidine.
Claim 17
Dependent Claim
11 words
A compound as described in claim 1 which is: 4-[4-(4-chlorophenylthio)-2-(4-tolyl)pyrimidin-6-yl]-1-piperazine ethanol.
Claim 18
Dependent Claim
10 words
A compound as described in claim 1 which is: 4-(4-chlorophenylthio)-2-(4-methoxyphenyl)-6-(4-methylpiperazin-1-yl)-pyrimidine.
Claim 19
Dependent Claim
10 words
A compound as described in claim 1 which is: 6-(4-chlorophenylthio)-4-(2-methoxyethylamino)-2-(4-methoxyphenyl)-pyrimidine.
Claim 20
Dependent Claim
10 words
A compound as described in claim 1 which is: 4-amino-6-(4-chlorobenzylthio)-2-phenylpyrimidine.
Claim 21
Dependent Claim
11 words
A compound as described in claim 1 which is: 4-(4-chlorophenylthio)-2-(3,4-dichlorophenyl)-6-[2-(dimethylamino)ethylamino]-pyrimidine[.1/2 cyclohexane].
References Cited (Backward Citations)
US3498984A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-02-23 | 1979-08-25 | 1980-02-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-02-23 | 1983-08-25 | 1984-02-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-02-23 | 1987-08-25 | 1988-02-24 | $7700.00 | Window Closed / Lapsed |