US3940393A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Synthesis of 2,6-diaminopyrimidines
Assignee: Wyeth LLC
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Filing: 1974-06-21
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Granted: 1976-02-24
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Expires: 1994-06-21
Abstract
Abstract New, substituted, 2,6-diaminopyrimidines are disclosed. These compounds are useful as anti-malarial agents. The oxygenation of pyrimethamine by fungi is also disclosed.
Inventors
- 👤 George Greenspan
- 👤 Richard W. Rees
- 👤 Peter B. Russell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 15:15
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/46; C07D239/48; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/911
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
59 words
A compound of the formula: ##SPC5## wherein R is phenyl, 3-chlorophenyl, 4-chlorophenyl, or 3,4-dichlorophenyl, X is C(OCH 3 ) 2 , C(OC 2 H 5 ) 2 , C=O, C=N--OH, C=N--NH 2 , C=N--N(CH 3 ) 2 , CHOH, or ##EQU6## R 1 is alkyl of from 1 to 6 carbon atoms; and their pharmacologically acceptable acid addition salts.
Claim 2
Dependent Claim
59 words
A compound of the formula: ##SPC5## wherein R is phenyl, 3-chlorophenyl, 4-chlorophenyl, or 3,4-dichlorophenyl, X is C(OCH 3 ) 2 , C(OC 2 H 5 ) 2 , C=O, C=N--OH, C=N--NH 2 , C=N--N(CH 3 ) 2 , CHOH, or ##EQU6## R 1 is alkyl of from 1 to 6 carbon atoms; and their pharmacologically acceptable acid addition salts.
Claim 3
Dependent Claim
46 words
A compound according to claim 1 of the formula: ##SPC6## wherein X is C(OCH 3 ) 2 , C(OC 2 H 5 ) 2 , C=O, C=N--OH, C=N--NH 2 , C=N--N(CH 3 ) 2 , CHOH, or ##EQU7## and the pharmacologically acceptable acid addition salts thereof.
Claim 4
Dependent Claim
7 words
The compound of claim 2, (±)-2,6-diamino-5-(p-chlorophenyl)-α-methyl-4-pyrimidine methanol.
Claim 5
Dependent Claim
7 words
The compound of claim 2, (+)-2,6-diamino-5-(p-chlorophenyl)-α-methyl-4-pyrimidine methanol.
Claim 6
Dependent Claim
7 words
The compound of claim 2, [2,6-diamino-5-(p-chlorophenyl)-4-pyrimidinyl]methyl ketone.
Claim 7
Dependent Claim
9 words
The compound of claim 2, [2,6-diamino-5-(p-chlorophenyl)-4-pyrimidinyl]methyl ketone, diethyl acetal.
Claim 8
Dependent Claim
9 words
The compound of claim 2, [2,6-diamino-5-(p-chlorophenyl)-4-pyrimidinyl]methyl ketone, dimethyl acetal.
Claim 9
Dependent Claim
9 words
The compound of claim 2, (-)-2,6-diamino-5-(p-chlorophenyl)-α-methyl-4-pyrimidine methanol, hydrochloride, hemihydrate.
Claim 10
Dependent Claim
8 words
The compound of claim 2, [2,6-diamino-5-(p-chlorophenyl)-4-pyrimidinyl]methyl ketone, dimethylhydrazone.
Claim 11
Dependent Claim
8 words
The compound of claim 2, [2,6-diamino-5-(p-chlorophenyl)-4-pyrimidinyl]methyl ketone oxime.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-02-23 | 1979-08-25 | 1980-02-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-02-23 | 1983-08-25 | 1984-02-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-02-23 | 1987-08-25 | 1988-02-24 | $7700.00 | Window Closed / Lapsed |