US3939259A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Coating composition and therapeutic preparation incorporating same
Assignee: Individual
•
Filing: 1974-05-24
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Granted: 1976-02-17
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Expires: 1994-05-24
Abstract
Abstract A therapeutic preparation consisting of particles containing a therapeutically active material are coated with a disintegratable coating comprising zein and shellac. A first group of particles contains no coating or a coating subject to rapid disintegration upon ingestion to release an initial dose of therapeutic material and remaining groups of particles are coated with increasingly thicker coatings for delayed disintegration to release subsequent doses of therapeutic material. The coating composition may include disintegration modifiers so that thinner coatings of the zein-shellac coating material can be employed than would be required for zein shellac alone to obtain the delayed disintegration of the coating.
Inventors
- 👤 Anthony Pescetti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 01:34
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5073; A61K9/5078
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
187 words
A therapeutic preparation comprising a pharmaceutical gelatin capsule containing a blend of three groups of particles containing a pharmaceutically active material, said first group containing a unit dose amount of said material for release thereof within a period of one hour after ingestion, a second group of said particles containing a unit dose amount of said material being provided with a coating comprising a major proportion of zein and shellac in a weight/weight ratio of between 1:7 and about 1:14 and minor proportions of ethyl cullulose, bees wax and a plasticizer, said coating having an effective thickness for disintegration and relase of said material in a period of about 4 hours after ingestion, and a third group of said particles containing a unit dose amount of said material being provided with a coating comprising a major proportion of zein and shellac in a weight/weight ratio of between about 1:7 and about 1:14 and minor proportions of ethyl cellulose, bees wax, polyvinylpyrrolidone and a plasticizer, said coating having an effective thickness for disintegration and relase of said material in about a period of about 8 hours after ingestion.
Claim 2
Dependent Claim
187 words
A therapeutic preparation comprising a pharmaceutical gelatin capsule containing a blend of three groups of particles containing a pharmaceutically active material, said first group containing a unit dose amount of said material for release thereof within a period of one hour after ingestion, a second group of said particles containing a unit dose amount of said material being provided with a coating comprising a major proportion of zein and shellac in a weight/weight ratio of between 1:7 and about 1:14 and minor proportions of ethyl cullulose, bees wax and a plasticizer, said coating having an effective thickness for disintegration and relase of said material in a period of about 4 hours after ingestion, and a third group of said particles containing a unit dose amount of said material being provided with a coating comprising a major proportion of zein and shellac in a weight/weight ratio of between about 1:7 and about 1:14 and minor proportions of ethyl cellulose, bees wax, polyvinylpyrrolidone and a plasticizer, said coating having an effective thickness for disintegration and relase of said material in about a period of about 8 hours after ingestion.
Claim 3
Dependent Claim
13 words
The therapeutic preparation of claim 1 wherein said pharmaceutically active material is digitoxin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-02-16 | 1979-08-18 | 1980-02-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-02-16 | 1983-08-18 | 1984-02-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-02-16 | 1987-08-18 | 1988-02-17 | $7700.00 | Window Closed / Lapsed |