US3937823A
Expired / Lapsed
US
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Topical anti-inflammatory compositions and methods of use
Assignee: Whitby Research Inc
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Filing: 1974-10-18
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Granted: 1976-02-10
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Expires: 1994-10-18
Abstract
Abstract Compositions especially useful for treating inflammation topically in animals comprising an active compound having the structural formula ##SPC1## Where R is H, lower alkyl, lower alkoxy, halogen, CF 3 , NO 2 , OH, CN, COOR 1 , ##EQU1## NHCOR 1 or NR 1 R 2 where R 1 and R 2 are each selected from the group consisting of H and lower alkyl, R, R 1 and R 2 being the same or different, and n is 0-5; and where X is an alkyl or alkenyl chain having 2-8 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group, and Y is hydrogen, alkyl, aryl, aralkyl or aryl and aralkyl substituted with one or more R; and pharmaceutically acceptable salts thereof, together with a pharmaceutical carrier containing an effective amount of an active radical having the structural formula ##SPC2## Where n is 1-4 and A is H or ##SPC3## And Z is H or --CH=NOH or --CONHOH and one and only one Z in a heterocyclic ring is H.
Inventors
- 👤 Frank Jeng Dea
- 👤 Richard Allen Schroer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 14:32
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/66
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
207 words
A composition for treating inflammation comprising about 0.1 to about 5% of an active compound having the structural formula ##SPC15## where R is selected from the group consisting of H, lower alkyl, lower alkoxy, halogen, CF.sub. 3, NO.sub. 2, OH, CN, COOR.sub. 1, CONR.sub. 1 R.sub. 2, NHCOR.sub. 1 and NR.sub. 1 R.sub. 2, R.sub. 1 and R.sub. 2 are each selected from the group consisting of H and lower alkyl, R, R.sub. 1 and R.sub. 2 being the same or different, and n is 0-5; and where X is selected from the group consisting of an alkyl chain and an alkenyl chain having 2-8 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group; and Y is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl or aryl and aralkyl substituted with one or more R, and pharmaceutically acceptable salts thereof, together with a topical pharmaceutical carrier containing an effective amount of an active radical having the structural formula ##SPC16## where n is 1-4, A is selected from the group consisting of H and ##SPC17## Z is selected from the group consisting of H, --CH=NOH and CONHOH where one and only one Z in each heterocyclic ring is H.
Claim 2
Dependent Claim
207 words
A composition for treating inflammation comprising about 0.1 to about 5% of an active compound having the structural formula ##SPC15## where R is selected from the group consisting of H, lower alkyl, lower alkoxy, halogen, CF.sub. 3, NO.sub. 2, OH, CN, COOR.sub. 1, CONR.sub. 1 R.sub. 2, NHCOR.sub. 1 and NR.sub. 1 R.sub. 2, R.sub. 1 and R.sub. 2 are each selected from the group consisting of H and lower alkyl, R, R.sub. 1 and R.sub. 2 being the same or different, and n is 0-5; and where X is selected from the group consisting of an alkyl chain and an alkenyl chain having 2-8 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group; and Y is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl or aryl and aralkyl substituted with one or more R, and pharmaceutically acceptable salts thereof, together with a topical pharmaceutical carrier containing an effective amount of an active radical having the structural formula ##SPC16## where n is 1-4, A is selected from the group consisting of H and ##SPC17## Z is selected from the group consisting of H, --CH=NOH and CONHOH where one and only one Z in each heterocyclic ring is H.
Claim 3
Dependent Claim
16 words
The composition of claim 1 where X is an alkyl chain having a 3 carbon atoms.
Claim 4
Dependent Claim
14 words
The composition of claim 2 where X contains a carbonyl group adjacent a ring.
Claim 5
Dependent Claim
15 words
The composition of claim 3 where Y is selected from the group consisting of ##SPC18##
Claim 6
Dependent Claim
23 words
The composition of claim 4 wherein R is selected from the group consisting of H, halogen and CF.sub. 3 and n is 1.
Claim 7
Dependent Claim
22 words
A method for treating inflammation in animals comprising applying topically to an animal an effective amount of the composition of claim 1.
Claim 8
Dependent Claim
22 words
A method for treating inflammation in animals comprising applying topically to an animal an effective amount of the composition of claim 4.
Claim 9
Dependent Claim
145 words
A composition for treating inflammation comprising about 0.5 to about 3% of an active compound having the structural formula ##SPC19## where X is selected from the group consisting of an alkyl chain and an alkenyl chain having 3 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group; and Y is selected from the group consisting of ##SPC20## where R is selected from the group consisting of H, lower alkyl, lower alkoxy and halogen, and pharmaceutically acceptable salts thereof, together with a topical pharmaceutical carrier containing about 0.5 to about 5% of an active radical having the structural formula ##SPC21## where n is 1-4, A is selected from the group consisting of H and ##SPC22## Z is selected from the group consisting of H, --CH=NOH and CONHOH where one and only one Z in each heterocyclic ring is H.
Claim 10
Dependent Claim
145 words
A composition for treating inflammation comprising about 0.5 to about 3% of an active compound having the structural formula ##SPC19## where X is selected from the group consisting of an alkyl chain and an alkenyl chain having 3 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group; and Y is selected from the group consisting of ##SPC20## where R is selected from the group consisting of H, lower alkyl, lower alkoxy and halogen, and pharmaceutically acceptable salts thereof, together with a topical pharmaceutical carrier containing about 0.5 to about 5% of an active radical having the structural formula ##SPC21## where n is 1-4, A is selected from the group consisting of H and ##SPC22## Z is selected from the group consisting of H, --CH=NOH and CONHOH where one and only one Z in each heterocyclic ring is H.
Claim 11
Dependent Claim
22 words
A method for treating inflammation in animals comprising applying topically to an animal an effective amount of a composition of claim 8.
Claim 12
Dependent Claim
130 words
A composition for treating inflammation comprising about 0.5 to about 3% of an active compound having the structural formula ##SPC23## where X is selected from the group consisting of an alkyl chain and an alkenyl chain having 3 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group; R is selected from the group consisting of H and halogen and pharmaceutically acceptable salts thereof, together with a topical pharmaceutical carrier containing about 0.5 to about 5% of an active radical having the structural formula ##SPC24## where n is 1-4, A is selected from the group consisting of H and ##SPC25## Z is selected from the group consisting of H, =CH=NOH and CONHOH where one and only one Z in each heterocyclic ring is H.
Claim 13
Dependent Claim
130 words
A composition for treating inflammation comprising about 0.5 to about 3% of an active compound having the structural formula ##SPC23## where X is selected from the group consisting of an alkyl chain and an alkenyl chain having 3 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group; R is selected from the group consisting of H and halogen and pharmaceutically acceptable salts thereof, together with a topical pharmaceutical carrier containing about 0.5 to about 5% of an active radical having the structural formula ##SPC24## where n is 1-4, A is selected from the group consisting of H and ##SPC25## Z is selected from the group consisting of H, =CH=NOH and CONHOH where one and only one Z in each heterocyclic ring is H.
Claim 14
Dependent Claim
54 words
A composition for treating inflammation comprising about 0.5 to about 3% of α-(4-chlorobenzyl)-α -benzyl-4-hydroxyacetophenone phenyl hydrogen phosphoric acid or a pharmaceutically acceptable salt thereof, together with a topical pharmaceutical carrier containing about 0.5 to about 5% of a compound having the structural formula ##SPC26## where one Z is H and one Z is --CH=NOH.
Claim 15
Dependent Claim
54 words
A composition for treating inflammation comprising about 0.5 to about 3% of α-(4-chlorobenzyl)-α -benzyl-4-hydroxyacetophenone phenyl hydrogen phosphoric acid or a pharmaceutically acceptable salt thereof, together with a topical pharmaceutical carrier containing about 0.5 to about 5% of a compound having the structural formula ##SPC26## where one Z is H and one Z is --CH=NOH.
Claim 16
Dependent Claim
143 words
A composition for treating inflammation comprising about 0.5 to about 3% of an active compound having the structural formula ##SPC27## where X is selected from the group consisting of an alkyl chain and an alkenyl chain having 3 carbon atoms, one of which carbon atoms is in the form of a carbonyl group; and Y is selected from the group consisting of ##SPC28## where R is selected from the group consisting of H, lower alkyl, lower alkoxy and halogen, and pharmaceutically acceptable salts thereof, together with a topical pharmaceutical carrier containing about 0.5 to about 5% of an active compound having the structural formula ##SPC29## where n is 1-4, A is selected from the group consisting of H and ##SPC30## Z is selected from the group consisting of H, --CH=NOH CONHOH where one and only one Z in each heterocyclic ring is H.
Claim 17
Dependent Claim
143 words
A composition for treating inflammation comprising about 0.5 to about 3% of an active compound having the structural formula ##SPC27## where X is selected from the group consisting of an alkyl chain and an alkenyl chain having 3 carbon atoms, one of which carbon atoms is in the form of a carbonyl group; and Y is selected from the group consisting of ##SPC28## where R is selected from the group consisting of H, lower alkyl, lower alkoxy and halogen, and pharmaceutically acceptable salts thereof, together with a topical pharmaceutical carrier containing about 0.5 to about 5% of an active compound having the structural formula ##SPC29## where n is 1-4, A is selected from the group consisting of H and ##SPC30## Z is selected from the group consisting of H, --CH=NOH CONHOH where one and only one Z in each heterocyclic ring is H.
Claim 18
Dependent Claim
25 words
A method for treating inflammation of the skin in animals comprising applying topically to an animal an effective amount of a composition of claim 12.
Claim 19
Dependent Claim
129 words
A composition for treating inflammation comprising about 0.5 to about 5% of an active compound having the structural formula ##SPC31## where X is selected from the group consisting of an alkyl chain and an alkenyl chain having 3 carbon atoms, one of which carbon atoms is in the form of a carbonyl group; R is selected from the group consisting of H and halogen and pharmaceutically acceptable salts thereof, together with a topical pharmaceutical carrier containing about 0.5 to about 5% of an active compound having the structural formula ##SPC32## where n is 1-4, A is selected from the group consisting of H and ##SPC33## Z is selected from the group consisting of H, =CH=NOH and CONHOH where one and only one Z in each heterocyclic ring is H.
Claim 20
Dependent Claim
129 words
A composition for treating inflammation comprising about 0.5 to about 5% of an active compound having the structural formula ##SPC31## where X is selected from the group consisting of an alkyl chain and an alkenyl chain having 3 carbon atoms, one of which carbon atoms is in the form of a carbonyl group; R is selected from the group consisting of H and halogen and pharmaceutically acceptable salts thereof, together with a topical pharmaceutical carrier containing about 0.5 to about 5% of an active compound having the structural formula ##SPC32## where n is 1-4, A is selected from the group consisting of H and ##SPC33## Z is selected from the group consisting of H, =CH=NOH and CONHOH where one and only one Z in each heterocyclic ring is H.
References Cited (Backward Citations)
FR2150791B1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-02-09 | 1979-08-11 | 1980-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-02-09 | 1983-08-11 | 1984-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-02-09 | 1987-08-11 | 1988-02-10 | $7700.00 | Window Closed / Lapsed |