US3933585A
Expired / Lapsed
US
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Process for production of vaccines
Assignee: Merck and Co Inc
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Filing: 1974-05-31
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Granted: 1976-01-20
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Expires: 1994-05-31
Abstract
Abstract A multiplate propagator for producing cells and vaccines having critical geometric properties such as ratio of plate diameter to internal tank diameter results in significantly increased yields at substantially reduced costs.
Inventors
- 👤 William J. McAleer
- 👤 Raymond E. Spier
- 👤 Kenneth L. Posch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 04:13
CPC Classifications
C; C12; C12N; C12N7/00; C12M; C12M23/00; C12M23/50; C12M25/00; C12M25/06; C12M27/00; C12M27/14; C12N2760/00; C12N2760/00011; C12N2760/18011; C12N2760/18411; C12N2760/18461; C12N2760/18464
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
37 words
A process for the production of a vaccine wherein the improvement comprises growing a desired virus in a rotating multiplate propagator having a plate diameter to internal tank diameter ratio of from about 0.80 to about 0.90.
Claim 2
Dependent Claim
37 words
A process for the production of a vaccine wherein the improvement comprises growing a desired virus in a rotating multiplate propagator having a plate diameter to internal tank diameter ratio of from about 0.80 to about 0.90.
Claim 3
Dependent Claim
16 words
A process as in claim 1 wherein the ratio is from about 0.82 to about 0.84.
Claim 4
Dependent Claim
60 words
A process for the production of a vaccine wherein the improvement comprises growing a desired virus in a rotating multiplate propagator having a distance of from about one-half inch to about three-fourths inch between the edge of the plates and the tank wall and having a plate diameter to internal tank diameter ratio of from about 0.80 to about 0.90.
Claim 5
Dependent Claim
60 words
A process for the production of a vaccine wherein the improvement comprises growing a desired virus in a rotating multiplate propagator having a distance of from about one-half inch to about three-fourths inch between the edge of the plates and the tank wall and having a plate diameter to internal tank diameter ratio of from about 0.80 to about 0.90.
Claim 6
Dependent Claim
56 words
A process for the production of a vaccine wherein the improvement comprises growing a desired virus in a multiplate propagator having a surface area to volume ratio of from about 1.7 cm. 2 /ml. to 2.2 cm. 2 /ml and having a plate diameter to internal tank diameter ratio of from about 0.80 to about 0.90.
Claim 7
Dependent Claim
56 words
A process for the production of a vaccine wherein the improvement comprises growing a desired virus in a multiplate propagator having a surface area to volume ratio of from about 1.7 cm. 2 /ml. to 2.2 cm. 2 /ml and having a plate diameter to internal tank diameter ratio of from about 0.80 to about 0.90.
Claim 8
Dependent Claim
78 words
A process for the production of a vaccine wherein the improvement comprises growing a desired virus in a rotating multiplate propagator having: a. a plate diameter to internal tank diameter of from about 0.80 to 0.90; b. a distance of from about one-half inch to about three-fourths inch between the edge of the plates and the tank wall; and c. a surface area to volume ratio of from about 1.7 cm. 2 /ml. to 2.2 cm. 2 /ml.
Claim 9
Dependent Claim
78 words
A process for the production of a vaccine wherein the improvement comprises growing a desired virus in a rotating multiplate propagator having: a. a plate diameter to internal tank diameter of from about 0.80 to 0.90; b. a distance of from about one-half inch to about three-fourths inch between the edge of the plates and the tank wall; and c. a surface area to volume ratio of from about 1.7 cm. 2 /ml. to 2.2 cm. 2 /ml.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-01-19 | 1979-07-21 | 1980-01-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-01-19 | 1983-07-21 | 1984-01-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-01-19 | 1987-07-21 | 1988-01-20 | $7700.00 | Window Closed / Lapsed |