US3932443A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sulphoxides
Assignee: GlaxoSmithKline LLC
•
Filing: 1974-01-24
•
Granted: 1976-01-13
•
Expires: 1994-01-24
Abstract
Abstract The compounds are sulphoxides of heterocyclicthioalkylthioureas, ureas and guanidines which are useful to produce inhibition of histamine H-2 receptors.
Inventors
- 👤 George Raymond White
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 17:17
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/64; A; A61; A61P; A61P43/00; C07D235/00; C07D235/02; C07D235/04; C07D235/06; C07D237/00; C07D237/02; C07D237/06; C07D237/08; C07D277/00; C07D277/02; C07D277/20; C07D277/22; C07D277/26; C07D285/00; C07D285/01; C07D285/02; C07D285/04; C07D285/12
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
97 words
A compound of the formula: ##EQU10## wherein A is such that the heterocyclic nucleus formed is an imidazole ring; X 1 and X 2 , which may be the same or different, are hydrogen, lower alkyl, trifluoromethyl, hydroxyl, halogen or amino; k is 0 to 2 and m is 2 or 3 provided that the sum of k and m is 3 or 4; E is oxygen, sulphur or NR 2 ; R 1 is hydrogen, lower alkyl, benzoyl or dimethylaminoethyl; and R 2 is hydrogen, nitro, cyano, alkanesulphonyl having 1--3 carbon atoms, benzenesulphonyl, halobenzenesulphonyl or toluenesulphonyl.
Claim 2
Dependent Claim
97 words
A compound of the formula: ##EQU10## wherein A is such that the heterocyclic nucleus formed is an imidazole ring; X 1 and X 2 , which may be the same or different, are hydrogen, lower alkyl, trifluoromethyl, hydroxyl, halogen or amino; k is 0 to 2 and m is 2 or 3 provided that the sum of k and m is 3 or 4; E is oxygen, sulphur or NR 2 ; R 1 is hydrogen, lower alkyl, benzoyl or dimethylaminoethyl; and R 2 is hydrogen, nitro, cyano, alkanesulphonyl having 1--3 carbon atoms, benzenesulphonyl, halobenzenesulphonyl or toluenesulphonyl.
Claim 3
Dependent Claim
20 words
A compound of claim 1 wherein X 1 is hydrogen, methyl, bromine, amino or hydroxyl and X 2 is hydrogen.
Claim 4
Dependent Claim
17 words
A compound of claim 1 wherein k is 1 or 2 and m is 2 or 3.
Claim 5
Dependent Claim
13 words
A compound of claim 3 wherein k is 1 and m is 2.
Claim 6
Dependent Claim
17 words
A compound of claim 1 wherein E is sulphur or NR 2 wherein R 2 is cyano.
Claim 7
Dependent Claim
10 words
A compound of claim 1 wherein R 1 is methyl.
Claim 8
Dependent Claim
11 words
A compound of claim 1, said compound being (5-methyl-4-imidazolyl)methyl 2-(N'-methylthioureido)ethyl sulphoxide.
Claim 9
Dependent Claim
11 words
A compound of claim 1, said compound being N-cyano-N'-methyl-N" -2-((4-methyl-5-imidazolyl)methylsulphinyl)ethyl guanidine.
References Cited (Backward Citations)
US3736331A
Cited
US3808336A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-01-12 | 1979-07-14 | 1980-01-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-01-12 | 1983-07-14 | 1984-01-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-01-12 | 1987-07-14 | 1988-01-13 | $7700.00 | Window Closed / Lapsed |