Penicillins having a 6β-(α-etherified oximino) acylamido group

Claim 1

A penicillin antibiotic of the formula ##EQU24## wherein R u is naphthyl; thienyl; benzothienyl or any of these groups substituted by chlorine, bromine, iodine, fluorine, hydroxy, lower alkyl, nitro, amino, lower alkylamino, diloweralkylamino, lower alkanoyl, lower alkanoylamino, lower alkoxy, lower alkylthio or carbamoyl and R e is alkyl of 1-16 carbon atoms; alkenyl of 2-16 carbon atoms; alkynyl of 2-16 carbon atoms; cycloalkyl of 3-7 carbon atoms; cycloalkenyl of 4-7 carbon atoms; phenyl; naphthyl; a heterocyclic radical selected from the group consisting of thienyl; furyl; pyridyl; pyrimidyl; pyrrolyl; N-methylpyrrolyl; N-benzyloxymethylpyrrolyl; thiazolyl; isothiazolyl; diazolyl; triazolyl; tetrazolyl; thiadiazolyl; thiatriazolyl; oxazolyl; oxadiazolyl; 3- or 4-isoxazolyl; sydnone; benzothienyl; benzofuryl; indolyl; benzimidazolyl; benzoxazolyl and purinyl; phenyl lower alkyl; diphenylmethyl; triphenylmethyl; naphthyl lower alkyl; heterocyclic lower alkyl in which the heterocyclic moiety is derived from said heterocyclic radical, or any of these groups substituted by hydroxy, lower alkoxy, phenoxy, benzyloxy, mercapto, lower alkylthio, phenylthio, benzylthio, amino, chlorine, bromine, iodine, fluorine, nitro, azido, carboxy, lower carbalkoxy, formyl, acetyl, propionyl, benzoyl, acetoxy, propionyloxy, pivaloyloxy, cyano, phthalimido, acetamido, benzamido, lower alkoxycarbonylamino or benzyloxycarbonylamino; or a physiologically acceptable salt thereof.