US3932375A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of 2-pyrimidine thiol carbonates as acylating agents for amino or imino containing compounds
Assignee: Nitto Boseki Co Ltd
•
Filing: 1974-06-13
•
Granted: 1976-01-13
•
Expires: 1994-06-13
Abstract
Abstract Thiolcarbonates represented by the formula, ##SPC1## Wherein R 1 and R 2 are individually a hydrogen atom or a methyl group, and R 3 is a straight chain or branched chain saturated or unsaturated alkyl group having 1 to 5 carbon atoms or is a benzyl or benzhydryl group which may be nuclear substituted, are quite useful for protecting the amino or imino groups of amines, hydrazines, amino acids and peptides with groups of the formula ##EQU1## The thiolcarbonates can be easily produced by reacting an alkali metal salt of 2-mercaptopyrimidine with phosgene, and reacting the resulting thiolchloroformate with an alcohol (R 3 OH), or by reacting a 2-mercaptopyrimidine with a halocarbonic acid ester.
Inventors
- 👤 Takeshi Nagasawa
- 👤 Katumasa Kuroiwa
- 👤 Kouichi Narita
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 22:12
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D209/20; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/582
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
167 words
A method for using a thiolcarbonate represented by the formula, ##SPC7## wherein R 1 and R 2 are individually a hydrogen atom or a methyl group, and R 3 is a straight chain or branched chain alkyl group having 1 to 5 carbon atoms, a straight chain or branched chain alkenyl group having 2 to 5 carbon atoms, or benzyl or benzhydryl group which may be nuclear substituted by a methoxy or nitro group of one or more halogen atoms, as an acylating agent for acylating the amino or imino group of a compound having amino and/or imino groups selected from the group consisting of aliphatic, aralkyl, alicyclic, aromatic and heterocyclic primary and secondary amines; hydrazines and derivatives thereof; amino acids, and peptides obtained from two or more of the said amino acids and derivatives thereof; and saccharides and steroids having amino and/or imino groups; in an inert organic solvent or in an aqueous solution thereof in the presence or absence of a base under mild conditions.
Claim 2
Independent Claim
167 words
A method for using a thiolcarbonate represented by the formula, ##SPC7## wherein R 1 and R 2 are individually a hydrogen atom or a methyl group, and R 3 is a straight chain or branched chain alkyl group having 1 to 5 carbon atoms, a straight chain or branched chain alkenyl group having 2 to 5 carbon atoms, or benzyl or benzhydryl group which may be nuclear substituted by a methoxy or nitro group of one or more halogen atoms, as an acylating agent for acylating the amino or imino group of a compound having amino and/or imino groups selected from the group consisting of aliphatic, aralkyl, alicyclic, aromatic and heterocyclic primary and secondary amines; hydrazines and derivatives thereof; amino acids, and peptides obtained from two or more of the said amino acids and derivatives thereof; and saccharides and steroids having amino and/or imino groups; in an inert organic solvent or in an aqueous solution thereof in the presence or absence of a base under mild conditions.
Claim 3
Dependent Claim
19 words
A method according to claim 1, wherein the acylation is carried out at a temperature of 0° to 80°C.
Claim 4
Dependent Claim
55 words
A method according to claim 1 wherein the compound having amino and/or imino groups is α-amino acids, β - or ω - amino acids, salts of said amino acids, acid esters or acid amides of said amino acids, synthetic or semi-synthetic amino acids, or N-terminal-free peptides obtained from two or more of said amino acids.
Claim 5
Dependent Claim
45 words
A method according to claim 1, wherein the compound having amino and/or imino groups is hydrazine or a derivative thereof having at least one substituent selected from the group consisting of phenyl, nitro and lower alkyl, or a salt of hydrazine or derivative of hydrazine.
Claim 6
Dependent Claim
26 words
A method according to claim 1, wherein the compound having amino and/imino groups is saccharides or steroids having primary or secondary amino groups, or salts thereof.
Claim 7
Dependent Claim
28 words
A method according to claim 1, wherein the compound having amino and/or imino groups is aliphatic, aralkyl, alicyclic, aromatic or heterocyclic primary or secondary amines or salts thereof.
Claim 8
Dependent Claim
33 words
A method according to claim 1, wherein a hydrohalide, sulfate or sulfide of the compound having amino and/or imino groups is used as a salt of the compound having amino and/or imino groups.
Claim 9
Dependent Claim
13 words
A method according to claim 1, wherein the base is a tertiary amine.
Claim 10
Dependent Claim
17 words
A method according to claim 8, wherein the tertiary amine is triethylamine, N-alkylmorpholine, N,N-dialkylaniline, pyridine or quinoline.
Claim 11
Dependent Claim
18 words
A method according to claim 1, wherein the base is a hydroxide, carbonate or bicarbonate of alkali metal.
Claim 12
Dependent Claim
29 words
A method according to claim 10, wherein the hydroxide, carbonate or bicarbonate of alkali metal is sodium hydroxide, potassium hydroxide, potassium carbonate, sodium carbonate, potassium bicarbonate or sodium bicarbonate.
Claim 13
Dependent Claim
18 words
A method according to claim 1, wherein the inert organic solvant is t-butyl alcohol, dioxane, tetrahydrofuran or dimethylformamide.
Claim 14
Independent Claim
116 words
A method for using a thiolcarbonate represented by the formula, ##SPC8## wherein R 1 and R 2 are individually a hydrogen atom or a methyl group, and R 3 is a group of the formula ##EQU47## wherein R 4 , R 5 and R 6 are individually a lower alkyl group, as an acylating agent for acylating a hydrazine or an aliphatic, aralkyl, alicyclic, aromatic or heterocyclic primary or secondary amine in the present of a base to produce a t-alkyloxy-carbonylamine represented by the formula, ##EQU48## wherein R, R and R are as defined above, and Z is a group formed by removing one hydrogen from the amino or imino group of the hydrazine or amine.
Claim 15
Independent Claim
116 words
A method for using a thiolcarbonate represented by the formula, ##SPC8## wherein R 1 and R 2 are individually a hydrogen atom or a methyl group, and R 3 is a group of the formula ##EQU47## wherein R 4 , R 5 and R 6 are individually a lower alkyl group, as an acylating agent for acylating a hydrazine or an aliphatic, aralkyl, alicyclic, aromatic or heterocyclic primary or secondary amine in the present of a base to produce a t-alkyloxy-carbonylamine represented by the formula, ##EQU48## wherein R, R and R are as defined above, and Z is a group formed by removing one hydrogen from the amino or imino group of the hydrazine or amine.
Claim 16
Independent Claim
104 words
A method of using a thiolcarbonate represented by the formula, ##SPC9## wherein R 1 and R 2 are individually a hydrogen atom or a methyl group and R 3 is a group of the formula ##SPC10## (wherein R 7 is as defined below), as an acylating agent for acylating a hydrazine or an aliphatic, aralkyl, alicyclic, aromatic or heterocyclic primary or secondary amine to produce an aralkyloxy-carbonylamine represented by the formula, ##SPC11## wherein R 7 is a hydrogen atom or a methoxy group, and Z is a group formed by removing one hydrogen from the amino or imino group of the hydrazine or amine.
Claim 17
Independent Claim
104 words
A method of using a thiolcarbonate represented by the formula, ##SPC9## wherein R 1 and R 2 are individually a hydrogen atom or a methyl group and R 3 is a group of the formula ##SPC10## (wherein R 7 is as defined below), as an acylating agent for acylating a hydrazine or an aliphatic, aralkyl, alicyclic, aromatic or heterocyclic primary or secondary amine to produce an aralkyloxy-carbonylamine represented by the formula, ##SPC11## wherein R 7 is a hydrogen atom or a methoxy group, and Z is a group formed by removing one hydrogen from the amino or imino group of the hydrazine or amine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-01-12 | 1979-07-14 | 1980-01-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-01-12 | 1983-07-14 | 1984-01-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-01-12 | 1987-07-14 | 1988-01-13 | $7700.00 | Window Closed / Lapsed |