US3931141A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Novel heptapeptides having gastrin activity
Assignee: Hoechst AG
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Filing: 1973-11-15
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Granted: 1976-01-06
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Expires: 1993-11-15
Abstract
Abstract Heptapeptides of the general formula HOOC--(CH.sub.2).sub.3 --CO--Ala--Tyr--Gly--Trp--X--Asp--Phe--NH.sub.2 in which X represents leucine or methionine, and process for preparing them by reacting tert.butyl-protected heptapeptides with glutaric acid anhydride and subsequently splitting off the protective groups with the aid of trifluoroacetic acid.
Inventors
- 👤 Hans Wissmann
- 👤 Rolf Geiger
- 👤 Rudolf Schleyerbach
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 23:48
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/595; A; A61; A61P; A61P1/00; A61P5/00; A61K; A61K38/00; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
23 words
A heptapeptide of the formula HOOC--(CH.sub.2).sub.3 --CO--Ala--Tyr--Gly--Trp--X--Asp--Phe--NH.sub.2, wherein X is leucine (Leu) or methionine (Met) and the optically-active amino acids are L-amino acids.
Claim 2
Dependent Claim
23 words
A heptapeptide of the formula HOOC--(CH.sub.2).sub.3 --CO--Ala--Tyr--Gly--Trp--X--Asp--Phe--NH.sub.2, wherein X is leucine (Leu) or methionine (Met) and the optically-active amino acids are L-amino acids.
Claim 3
Dependent Claim
13 words
A heptapeptide as defined in claim 1 in which X represents leucine (Leu).
Claim 4
Dependent Claim
13 words
A heptapeptide as defined in claim 1 in which X represents methionine (Met).
Claim 5
Independent Claim
92 words
A method for making a heptapeptide of the formula HOOC--(CH.sub.2).sub.3 --CO--Ala--Tyr--Gly--Trp--X--Asp--Phe--NH.sub.2, wherein the optically-active amino acids are L-amino acids and wherein X is leucine (Leu) or methionine (Met), which method comprises reacting glutaric acid anhydride with a peptide wherein the optically-active amino acids are L-amino acids, said peptide having the formula H--Ala--Tyr(Bu.sup.t)--Gly--Trp--X--Asp(OBu.sup.t)--Phe--NH.sub.2, wherein Bu t is tert. butyl, to form a reaction product of the formula HOOC--(CH.sub.2).sub.3 --CO--Ala--Tyr(Bu.sup.t)--Gly--Trp--X--Asp(OBu.sup.t)--Phe--NH.sub.2, wherein the optically-active amino acids are L-amino acids, and then treating said reaction product with trifluoroacetic acid to remove the protective tert. butyl groups.
Claim 6
Independent Claim
92 words
A method for making a heptapeptide of the formula HOOC--(CH.sub.2).sub.3 --CO--Ala--Tyr--Gly--Trp--X--Asp--Phe--NH.sub.2, wherein the optically-active amino acids are L-amino acids and wherein X is leucine (Leu) or methionine (Met), which method comprises reacting glutaric acid anhydride with a peptide wherein the optically-active amino acids are L-amino acids, said peptide having the formula H--Ala--Tyr(Bu.sup.t)--Gly--Trp--X--Asp(OBu.sup.t)--Phe--NH.sub.2, wherein Bu t is tert. butyl, to form a reaction product of the formula HOOC--(CH.sub.2).sub.3 --CO--Ala--Tyr(Bu.sup.t)--Gly--Trp--X--Asp(OBu.sup.t)--Phe--NH.sub.2, wherein the optically-active amino acids are L-amino acids, and then treating said reaction product with trifluoroacetic acid to remove the protective tert. butyl groups.
References Cited (Backward Citations)
US3652531A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-01-05 | 1979-07-07 | 1980-01-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-01-05 | 1983-07-07 | 1984-01-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-01-05 | 1987-07-07 | 1988-01-06 | $7700.00 | Window Closed / Lapsed |