US3930008A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4-Aryl-5-aminoalkyl-4-oxazolin-2-ones
Assignee: Istituto Luso Farmaco dItalia SpA
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Filing: 1973-10-03
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Granted: 1975-12-30
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Expires: 1993-10-03
Abstract
Abstract represents a secondary or tertiary amino residue, Z represents an oxygen or sulphur atom, or an imino group, and R3 represents a hydrogen atom or a lower alkyl, a lower free or etherified hydroxyalkyl, an arylalkyl, a dialkylaminoalkyl, a lower aliphatic acyl, a lower aromatic acyl or a carbamoyl radical are provided with depressive or stimulative activity on the central nervous system, with hypotensive, muscular relaxing properties, which inhibits aggregation of platelets and which is antiarrhythmic and antihistaminic. or a pharmaceutically acceptable salt thereof, in which Ar represents a mono or polycyclic, substituted or unsubstituted, aryl radical, Alk represents a linear or branched saturated or unsaturated hydrocarbon radical of one to three carbon atoms, A class of 4-aryl-5-aminoalkyl-4-oxazolin-2-ones having the general formula:
Inventors
- 👤 Elso Manghisi
- 👤 Giuseppe Cascio
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 12:00
CPC Classifications
C; C07; C07D; C07D263/00; C07D263/02; C07D263/30; C07D263/34; C07D263/48; C07D263/36; C07D263/38; C07D263/46
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
55 words
A 4-ARYL-5-AMINOALKYL-4-OXAZOLIN-2-ONE SELECTED FROM THE GROUP CONSISTING OF 4-FLUOROPHENYL-5-B-(-4-PHENYLPIPERAZINO) ETHYL-4-OXAZOLIN-2-ONE, 4-P-FLUOROPHENYL-5-B-(4O-METHOXY-PHENYL-PIPERAZINO)ETHYL-4-OXAZOLIN-2-ONE, 4-PHENYL-5-B-(4-PHENYL-PIPERAZINO)-ETHYL-4-OXAZOLIN-2-ONE, 4-PCHLOROPHENYL-5-B-(4-PHENYL-PIPERAZINO) ETHYL-4-OXAZOLIN2-ONE, 4-P-METHOXY-PHENYL-5-B-(4-PHENYL-PIPERAZINO) ETHYL4-OXAZOLIN-2-ONE, 3-METHYL-4-P-FLUOROPHENYL-5-B-(4-PHENYLPIPERAZINO) ETHYL-4-OXAZOLIN-2-ONE, 3-ETHYL-4-P-FLUOROPHELYL5-B-(4-PHENYL-PIPERAZINO) ETHYL-4-OXAZOLIN-2-ONE, 3-BUTY-4P-FLUOROPHENYL-5-B-(4-PHENYL-PIPERAZINO) ETHYL-4-OXAZOLIN-2ONE, 3-BENZYL-4-FLUOROPHENYL-5-B-(4-PHENYL-PIPERAZINO) ETHYL-4-OXAZOLIN:2-ONE, 3-DIETHYL-AMINOETHYL-4-P-FLUOROPHENYL-5-B-(4-PHENYL-PIPERAZINO) ETHYL-4-OXAZOLIN-2-ONE, 3-ACETYL-4-P-FLUOROPHENYL-5-B-(4-PHENYL-PIPERAZINO) ETHYL-4-OXAZOLIN-2-ONE, 3-BENZOYL-4-P-FLUOROPHENYL-5-B-(4PIPERAZINO) ETHYL-4-OXAZOLIN-2-ONE, 4-P-FLUOROPHENYL-5-B-(4(2 PYRIDYL)-PIPERAZINO) ETHYL-4-OXAZOLIN -2-ONE, 4-PFLUOROPHENYL-5-B-(4-METHYL-PIPERAZINO) ETHYL-4-OXAZOLIN2-ONE, 3-PHENYL-4-P-FLUOROPHENYL-5-B-(4-PHENYL-PIPERAZINO) ETHYL-4-OXAZOLIN-2-ONE, 3-METHYLAMINO-CARBONYL-4-PFLUOROPHENYL-5-B-(4-PHENYL-PIPERAZINO)ETHYL-4 -OXAZOLIN 2-ONE, 3-ACETYL-4-P-FLUOROPHENYL-5-B-(4-O-METHOXYPHENYLPIPERAZINO)ETHYL-4-OXAZOLIN -2-ONE, 4-P-FLUOROPHENYL-5-B-(4PHENYL-PIPERAZINO)ETHYL-4-OXAZOLIN-2-THIONE, 4-P-FLUOROPHENYL-5-B-(4-O-METHOXYPHENYL-PIPERAZINO)ETHYL-4-OXAZOLIN -2THIONE,, 4-P-FLUOROPHENYL-5-B-(4-PHENYLPIPERAZINO) ETHYL-2IMINO-OXAZOLINE, 4-P-FLUOROPHENYL-5-B-(4-O-,METHOXYPHENYLPIPERAZINO)ETHYL-2-IMINO-OXAZOLINE, AND A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF.
Claim 2
Dependent Claim
55 words
A 4-ARYL-5-AMINOALKYL-4-OXAZOLIN-2-ONE SELECTED FROM THE GROUP CONSISTING OF 4-FLUOROPHENYL-5-B-(-4-PHENYLPIPERAZINO) ETHYL-4-OXAZOLIN-2-ONE, 4-P-FLUOROPHENYL-5-B-(4O-METHOXY-PHENYL-PIPERAZINO)ETHYL-4-OXAZOLIN-2-ONE, 4-PHENYL-5-B-(4-PHENYL-PIPERAZINO)-ETHYL-4-OXAZOLIN-2-ONE, 4-PCHLOROPHENYL-5-B-(4-PHENYL-PIPERAZINO) ETHYL-4-OXAZOLIN2-ONE, 4-P-METHOXY-PHENYL-5-B-(4-PHENYL-PIPERAZINO) ETHYL4-OXAZOLIN-2-ONE, 3-METHYL-4-P-FLUOROPHENYL-5-B-(4-PHENYLPIPERAZINO) ETHYL-4-OXAZOLIN-2-ONE, 3-ETHYL-4-P-FLUOROPHELYL5-B-(4-PHENYL-PIPERAZINO) ETHYL-4-OXAZOLIN-2-ONE, 3-BUTY-4P-FLUOROPHENYL-5-B-(4-PHENYL-PIPERAZINO) ETHYL-4-OXAZOLIN-2ONE, 3-BENZYL-4-FLUOROPHENYL-5-B-(4-PHENYL-PIPERAZINO) ETHYL-4-OXAZOLIN:2-ONE, 3-DIETHYL-AMINOETHYL-4-P-FLUOROPHENYL-5-B-(4-PHENYL-PIPERAZINO) ETHYL-4-OXAZOLIN-2-ONE, 3-ACETYL-4-P-FLUOROPHENYL-5-B-(4-PHENYL-PIPERAZINO) ETHYL-4-OXAZOLIN-2-ONE, 3-BENZOYL-4-P-FLUOROPHENYL-5-B-(4PIPERAZINO) ETHYL-4-OXAZOLIN-2-ONE, 4-P-FLUOROPHENYL-5-B-(4(2 PYRIDYL)-PIPERAZINO) ETHYL-4-OXAZOLIN -2-ONE, 4-PFLUOROPHENYL-5-B-(4-METHYL-PIPERAZINO) ETHYL-4-OXAZOLIN2-ONE, 3-PHENYL-4-P-FLUOROPHENYL-5-B-(4-PHENYL-PIPERAZINO) ETHYL-4-OXAZOLIN-2-ONE, 3-METHYLAMINO-CARBONYL-4-PFLUOROPHENYL-5-B-(4-PHENYL-PIPERAZINO)ETHYL-4 -OXAZOLIN 2-ONE, 3-ACETYL-4-P-FLUOROPHENYL-5-B-(4-O-METHOXYPHENYLPIPERAZINO)ETHYL-4-OXAZOLIN -2-ONE, 4-P-FLUOROPHENYL-5-B-(4PHENYL-PIPERAZINO)ETHYL-4-OXAZOLIN-2-THIONE, 4-P-FLUOROPHENYL-5-B-(4-O-METHOXYPHENYL-PIPERAZINO)ETHYL-4-OXAZOLIN -2THIONE,, 4-P-FLUOROPHENYL-5-B-(4-PHENYLPIPERAZINO) ETHYL-2IMINO-OXAZOLINE, 4-P-FLUOROPHENYL-5-B-(4-O-,METHOXYPHENYLPIPERAZINO)ETHYL-2-IMINO-OXAZOLINE, AND A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF.
References Cited (Backward Citations)
US3576808A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-29 | 1979-06-30 | 1979-12-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-29 | 1983-06-30 | 1983-12-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-29 | 1987-06-30 | 1987-12-30 | $7700.00 | Window Closed / Lapsed |