US3930006A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antiparkinsonism compositions and method
Assignee: Aspro Nicholas Ltd
•
Filing: 1965-07-22
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Granted: 1975-12-30
•
Expires: 1985-07-22
Abstract
Abstract A method is provided for ameliorating symptoms of paralysis agitans by administering to a subject exhibiting this syndrome an effective dose of a compound having anti-Parkinsonism activity, and having the general structure and pharmaceutically acceptable salts thereof.
Inventors
- 👤 Leslie Frederick Wiggins
- 👤 John William James
- 👤 Maurice Ward Gittos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 12:01
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61K31/513; A61K31/515
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
37 words
A METHOD OF AMELIORATING SYMPTOMA OF PARALYSIS AGITANS COMPRISING ADMINISTERING TO A SUBJECT EXHABITING THE SYNDROME THEREOF AN EFFECTIVE DOSE OF A COMPOUND HAVING ANTI-PARKINSONISM ACTIVITY SELECTED FROM THE GROUP CONSISTING OF A COMPOUND OF THE FORMULA
Claim 2
Independent Claim
37 words
A METHOD OF AMELIORATING SYMPTOMA OF PARALYSIS AGITANS COMPRISING ADMINISTERING TO A SUBJECT EXHABITING THE SYNDROME THEREOF AN EFFECTIVE DOSE OF A COMPOUND HAVING ANTI-PARKINSONISM ACTIVITY SELECTED FROM THE GROUP CONSISTING OF A COMPOUND OF THE FORMULA
Claim 3
Dependent Claim
20 words
A method as claimed in claim 1, wherein R1 is selected from the class consisting of 2''-diethylaminoethyl, 2''-piperidinylmethyl and N-methyl-2''-piperidinylmethyl.
Claim 4
Dependent Claim
15 words
A method as claimed in claim 2, wherein X is oxygen, and R1 is 2''-piperidinylmethyl.
Claim 5
Dependent Claim
15 words
A method as claimed in claim 1, wherein X is oxygen, and R1 is 2''-piperidinylmethyl.
Claim 6
Dependent Claim
16 words
A method as claimed in claim 4 wherein the compound is in acid addition salt form.
Claim 7
Dependent Claim
17 words
A method as claimed in claim 5 wherein the acid addition salt is in hydrochloride salt form.
Claim 8
Dependent Claim
15 words
A method as claimed in claim 1, wherein X is sulphur, and R1 is N-methyl-2''-piperidinylmethyl.
Claim 9
Dependent Claim
15 words
A method as claimed in claim 1, wherein X is oxygen and R1 is 2''-diethylaminoethyl.
Claim 10
Dependent Claim
15 words
A method as claimed in claim 1, wherein X is sulphur, and R1 is 2''-diethylaminoethyl.
Claim 11
Independent Claim
22 words
A method of ameliorating paralysis agitans comprising administering to a subject exhibiting the syndrome thereof an effective dose of 5-cyclohexyl-5-(2''-dimethylaminoethyl)-2-thiobarbituric acid compound.
Claim 12
Independent Claim
22 words
A method of ameliorating paralysis agitans comprising administering to a subject exhibiting the syndrome thereof an effective dose of 5-cyclohexyl-5-(2''-dimethylaminoethyl)-2-thiobarbituric acid compound.
Claim 13
Dependent Claim
38 words
A pharmaceutical composition in dosage unit form, for ameliorating symptoms of paralysis agitans, comprising a pharmaceutical carrier and an effective amount of a compound having anti-Parkinsonism activity selected from the group consisting of a compound of the formula:
Claim 14
Dependent Claim
38 words
A pharmaceutical composition in dosage unit form, for ameliorating symptoms of paralysis agitans, comprising a pharmaceutical carrier and an effective amount of a compound having anti-Parkinsonism activity selected from the group consisting of a compound of the formula:
Claim 15
Dependent Claim
21 words
A pharmaceutical composition as claimed in claim 11, wherein R1 is selected from the class consisting of 2''-diethylaminoethyl, 2''-piperidinylmethyl and N-methyl-2''-piperidinylmethyl.
Claim 16
Dependent Claim
12 words
A pharmaceutical composition as claimed in claim 12, wherein X is oxygen.
Claim 17
Dependent Claim
16 words
A pharmaceutical composition as claimed in claim 11, wherein X is oxygen and R1 is 2''-piperidinylmethyl.
Claim 18
Dependent Claim
13 words
A pharmaceutical composition as claimed in claim 14, in acid addition salt form.
Claim 19
Dependent Claim
12 words
A pharmaceutical composition as claimed in claim 15, in hydrochloride salt form.
Claim 20
Dependent Claim
16 words
A pharmaceutical composition as claimed in claim 11, wherein X is sulphur and R1 is N-methyl-2''-piperidinylmethyl.
Claim 21
Dependent Claim
16 words
A pharmaceutical composition as claimed in claim 11, wherein X is oxygen, and R1 is 2''-diethylaminoethyl.
Claim 22
Dependent Claim
16 words
A pharmaceutical composition as claimed in claim 11, wherein X is sulphur and R1 is 2''-diethylaminoethyl.
Claim 23
Dependent Claim
25 words
A pharmaceutical Composition in dosage unit form, for ameliorating symptoms of paralysis agitans, comprising a pharmaceutical carrier and an effective amount of 5-cyclohexyl-5-(2''-dimethylaminoethyl)-2-thiobarbituric acid compound.
Claim 24
Dependent Claim
25 words
A pharmaceutical Composition in dosage unit form, for ameliorating symptoms of paralysis agitans, comprising a pharmaceutical carrier and an effective amount of 5-cyclohexyl-5-(2''-dimethylaminoethyl)-2-thiobarbituric acid compound.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-29 | 1979-06-30 | 1979-12-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-29 | 1983-06-30 | 1983-12-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-29 | 1987-06-30 | 1987-12-30 | $7700.00 | Window Closed / Lapsed |