US3928581A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Certain polymer-iron complexes for treatment of iron deficiency
Assignee: Astra Lakemedel AB
•
Filing: 1973-03-22
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Granted: 1975-12-23
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Expires: 1993-03-22
Abstract
Abstract The present invention relates to a process for preparing a polymer which is suitable for being administered parenterally from a saccharide, a polyhydric alcohol and a polymerization agent and to the polymer prepared therefrom. The invention relates also to an iron preparation suitable for parenteral intramuscular and intravenous - injection, to a process for the preparation of the iron preparation, and to the use of the injectable iron preparations in human and veterinary medicine.
Inventors
- 👤 Alf-Goran Dahlberg
- 👤 Karl Gustav Hogberg
- 👤 Sven Lindvall
- 👤 Thore Oskar Verner Rydh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 00:58
CPC Classifications
C; C08; C08G; C08G65/00; C08G65/02; C08G65/32; C08G65/321; C08G65/325; A; A61; A61K; A61K33/00; A61K33/24; A61K33/26; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08G65/26; C08G65/2603; C08G65/2606; C08G65/324; C08G85/00; C08G85/004
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
58 words
A COMPOSITION FOR TREATMENT OF IRON DEFICIENCY BY PARENTERAL ADMINISTRATION COMPRISING AN AQUEOUS SOLUTION OF A COMPLEX OF A FERRIC IRON, SAID COMPLEX CONTAINING FERRIC IRON WHICH IS BOUND TO A POLYMER WHEREIN SAID COMPLEX IS PREPARED BY A. REACTING IN AN AQUEOUS SOLUTION AT A TEMPERATURE BETWEEN ABOUT 20*C AND THE BOILING POINT OF THE REACTION MIXTURE
Claim 2
Dependent Claim
58 words
A COMPOSITION FOR TREATMENT OF IRON DEFICIENCY BY PARENTERAL ADMINISTRATION COMPRISING AN AQUEOUS SOLUTION OF A COMPLEX OF A FERRIC IRON, SAID COMPLEX CONTAINING FERRIC IRON WHICH IS BOUND TO A POLYMER WHEREIN SAID COMPLEX IS PREPARED BY A. REACTING IN AN AQUEOUS SOLUTION AT A TEMPERATURE BETWEEN ABOUT 20*C AND THE BOILING POINT OF THE REACTION MIXTURE
Claim 3
Dependent Claim
29 words
ABOUT 0.1 TO 1.0 MOLES OF A SACCHARIDE (PER MOLE OF COMPONENT (3) BELOW) WHICH IS SELECTED FROM THE GROUP CONSISTING OF A. SUCROSE, B. TREHALOSE, AND C. RAFFINOSE;
Claim 4
Dependent Claim
29 words
ABOUT 0.1 TO 1.0 MOLES OF A SACCHARIDE (PER MOLE OF COMPONENT (3) BELOW) WHICH IS SELECTED FROM THE GROUP CONSISTING OF A. SUCROSE, B. TREHALOSE, AND C. RAFFINOSE;
Claim 5
Dependent Claim
18 words
ABOUT 0.05 TO 5 MOLES OF A POLYMERIZATION AGENT (PER MOLE OF COMPONENT (3) BELOW) OF THE FORMULA
Claim 6
Dependent Claim
18 words
ABOUT 0.05 TO 5 MOLES OF A POLYMERIZATION AGENT (PER MOLE OF COMPONENT (3) BELOW) OF THE FORMULA
Claim 7
Dependent Claim
17 words
A composition according to claim 1 wherein the polymerization agent is selected from the group consisting of
Claim 8
Dependent Claim
18 words
about 0.05 to 5 moles of a polymerization agent (per mole of component (3) below) of the formula
Claim 9
Dependent Claim
18 words
about 0.05 to 5 moles of a polymerization agent (per mole of component (3) below) of the formula
Claim 10
Dependent Claim
127 words
A HEXITOL SELECTED FROM THE GROUP CONSISING OF SORBITOL HYDROXYPROPYL SORBITOL, MANNITOL, TALITOL, IDITOL, GALACTITOL, AND ALLITOL TO FORM A FIRST INTERMEDIATE OF THE FORMULA (POLYMER)>C=O B. REACTING SAID FIRST INTERMEDIATE PRODUCT WITH A CYANIDE SELECTED FROM THE GROUP CONSISTING OF KCN,NACN CA(CN)2, HCN, ANDNH4CN IN AN AMOUNT AT LEAST EQUIMOLAR WITH THE AMOUNT OF CARBONYL GROUPS ON THE FIRST INTERMEDIATE PRODUCT TO FORM A SECOND INTERMEDIATE PRODUCT OF THE FORMULA (POLYMER)>C(-CN)-O(-) C. ACIDIFYING SAID SECOND INTERMEDIATE PRODUCT TO FORM A THIRD INTERMEDIATE PRODUCT OF THE FORMULA (POLYMER)>C(-CN)-OH D. HYDROLYZIING SAID THIRD INTERMEDIATE PRODUCT OT FORM A WATER SWELLABLE POLYMER OF THE FORMULA (POLYMER)>C(-COOH)-OH AND E. REACTING SAID WATER SWELLABLE POLYMER WITH A FERRIC COMPOUND IN SOLUTION UNDER ALKALINE CONDITIONS TO FORM SAID COMPLEX OF FERRIC IRON.
Claim 11
Dependent Claim
127 words
A HEXITOL SELECTED FROM THE GROUP CONSISING OF SORBITOL HYDROXYPROPYL SORBITOL, MANNITOL, TALITOL, IDITOL, GALACTITOL, AND ALLITOL TO FORM A FIRST INTERMEDIATE OF THE FORMULA (POLYMER)>C=O B. REACTING SAID FIRST INTERMEDIATE PRODUCT WITH A CYANIDE SELECTED FROM THE GROUP CONSISTING OF KCN,NACN CA(CN)2, HCN, ANDNH4CN IN AN AMOUNT AT LEAST EQUIMOLAR WITH THE AMOUNT OF CARBONYL GROUPS ON THE FIRST INTERMEDIATE PRODUCT TO FORM A SECOND INTERMEDIATE PRODUCT OF THE FORMULA (POLYMER)>C(-CN)-O(-) C. ACIDIFYING SAID SECOND INTERMEDIATE PRODUCT TO FORM A THIRD INTERMEDIATE PRODUCT OF THE FORMULA (POLYMER)>C(-CN)-OH D. HYDROLYZIING SAID THIRD INTERMEDIATE PRODUCT OT FORM A WATER SWELLABLE POLYMER OF THE FORMULA (POLYMER)>C(-COOH)-OH AND E. REACTING SAID WATER SWELLABLE POLYMER WITH A FERRIC COMPOUND IN SOLUTION UNDER ALKALINE CONDITIONS TO FORM SAID COMPLEX OF FERRIC IRON.
Claim 12
Dependent Claim
38 words
The composition according to claim 1, in which the ferric iron is derived from a compound selected from the group consisting of: a. ferric chloride, b. ferric nitrate, c. ferric sulfate, d. ferric acetate, e. double salts thereof.
Claim 13
Dependent Claim
75 words
a hexitol selected from the group consisting of sorbitol, hydroxypropyl sorbitol, mannitol, talitol, iditol, galactitol, and allitol to form a first intermediate of the formula (polymer)>C 0 I; B. reacting said first intermediate product with a cyanide selected from the group consisting of KCN, NaCN, Ca(CN)2, HCN, and NH4CN in an amount at least equimolar with the amount of carbonyl groups on the first intermediate product to form a second intermediate product of the formula
Claim 14
Dependent Claim
75 words
a hexitol selected from the group consisting of sorbitol, hydroxypropyl sorbitol, mannitol, talitol, iditol, galactitol, and allitol to form a first intermediate of the formula (polymer)>C 0 I; B. reacting said first intermediate product with a cyanide selected from the group consisting of KCN, NaCN, Ca(CN)2, HCN, and NH4CN in an amount at least equimolar with the amount of carbonyl groups on the first intermediate product to form a second intermediate product of the formula
Claim 15
Dependent Claim
16 words
The composition according to claim 1, in which the ferric iron is derived from ferric chloride.
Claim 16
Dependent Claim
13 words
The composition according to claim 1 which contains about 5 to 40% iron.
Claim 17
Dependent Claim
19 words
A composition according to claim 1 wherein the polymerization agent is a structure V compound wherein X is Cl.
Claim 18
Dependent Claim
19 words
A composition according to claim 1 wherein the polymerization agent is a structure VIII compound wherein X is Cl.
Claim 19
Dependent Claim
19 words
A composition according to claim 1 wherein the polymerization agent is a structure VIII compound wherein X is Br.
Claim 20
Dependent Claim
19 words
A composition according to claim 1 wherein the polymerization agent is a structure XI compound wherein n is 0.
Claim 21
Dependent Claim
19 words
A composition according to claim 1 wherein the polymerization agent is a structure VII compound wherein X is Cl.
Claim 22
Dependent Claim
11 words
A composition according to claim 1 wherein the hexitol is sorbitol.
Claim 23
Dependent Claim
11 words
A composition according to claim 1 wherein the hexitol is galactitol.
Claim 24
Dependent Claim
11 words
A composition according to claim 1 wherein the hexitol is mannitol.
Claim 25
Dependent Claim
21 words
A composition according to claim 1 wherein trehalose is the saccharide, sorbitol is the hexitol and epichlorohydrin is the polymerization agent.
Claim 26
Dependent Claim
21 words
A composition according to claim 1 wherein raffinose is the saccharide, sorbitol is the hexitol, and epichlorohydrin is the polymerization agent.
Claim 27
Dependent Claim
21 words
A composition according to claim 1 wherein sUcrose is the saccharide, mannitol is the hexitol, and epichlorohydrin is the polymerization agent.
Claim 28
Dependent Claim
21 words
A composition according to claim 1 wherein sucrose is the saccharide, galactitol is the hexitol, and epichlorohydrin is the polymerization agent.
Claim 29
Dependent Claim
21 words
A composition according to claim 1 wherein sucrose is the saccharide, hydroxypropylsorbitol is the hexitol, and epichlorohydrin is the polymerization agent.
Claim 30
Dependent Claim
21 words
A composition according to claim 1 wherein sucrose is the saccharide, sorbitol is the hexitol, and epichlorohydrin is the polymerization agent.
References Cited (Backward Citations)
US3275576A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-22 | 1979-06-23 | 1979-12-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-22 | 1983-06-23 | 1983-12-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-22 | 1987-06-23 | 1987-12-23 | $7700.00 | Window Closed / Lapsed |