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US3928135A Expired / Lapsed US ⏱️ 0.0 years remaining

Process for the production of glucose polymers

Assignee: Individual
•
Filing: 1973-05-02
•
Granted: 1975-12-23
•
Expires: 1993-05-02
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Abstract

Abstract Glucose polymers having therapeutic value in warm-blooded animals without the sweetness and hyperosmolarity in veins or intestinal tissues attendant with liquid glucose.

Inventors

  • 👤 Jeremiah Milner

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-06 04:51
CPC Classifications
C; C08; C08B; C08B30/00; C08B30/12; C08B30/18; A; A61; A61K; A61K31/00; A61K31/70; A61K31/715

Claims Analysis

Total Claims: 14
Claim 1
Independent Claim 188 words
PROCESS FOR THE PRODUCTION OF GLUCOSE POLYMERS WHICH COMPRISES A. HYDROLYSING STARCH CONTAINING NO MORE THAN 20% OF AMYLOPECTIN BY MEANS OF AN A -AMYLASE ENZYME IS A BUFFER SOLUTION AT A PH OF ABOUT 6.5, B. HEATING THE RESULTING MIXTURE IN SOLUTION TO A SUFFICIENTLY ELEVATED TEMPERATURE TO DESTROY THE ENZYME, STOPPING THE HYDROLYSIS REACTION WHEN THE GLUCOSE LEVEL RISES TO ABOUT 3% BY WEIGHT OF THE TOTAL DEXTRINS, C. REMOVING ELECTROLYTES BY PASSING THE MIXTURE THROUGH A ION-EXCHANGE RESIN OR BY MAKING A SOLUTION OF THE MIXTURE IN WATER ADDING AN ALCOHOL TO FORM A DEXTRIN PRECIPITATE LEAVING THE ELECTROLYTE IN SOLUTION, DISSOLVING THE PRECIPITATE IN AQUEOUS ALCOHOL AND DISTILLING OF THE ALCOHOL, D. BOILING THE SOLUTION TO REDUCE PYROGENS, E. PASSING THE SOLUTION THROUGH A CANDLE OF SEITZ FILTER TO REMOVE BACTERIAL AND UNWANTED PROTEIN SUBSTANCES, F. REMOVING GLUCOSE BY DIALYSIS OR BY MEANS OF A DEXTRAN RESIN COLUMN, AND G. REMOVING THE LONG CHAIN DEXTRINS BY FRACTIONATION WITH ALCOHOL AND THEREAFTER RECOVERING GLUCOSE POLYMERS IN WHICH GLUCOSE UNITS IN THE POLYMER LINKED IN THE 1,6-POSITION CONSTITUTED NO MORE THAN 5% OF THE TOTAL LINKAGES.
Claim 2
Dependent Claim 188 words
PROCESS FOR THE PRODUCTION OF GLUCOSE POLYMERS WHICH COMPRISES A. HYDROLYSING STARCH CONTAINING NO MORE THAN 20% OF AMYLOPECTIN BY MEANS OF AN A -AMYLASE ENZYME IS A BUFFER SOLUTION AT A PH OF ABOUT 6.5, B. HEATING THE RESULTING MIXTURE IN SOLUTION TO A SUFFICIENTLY ELEVATED TEMPERATURE TO DESTROY THE ENZYME, STOPPING THE HYDROLYSIS REACTION WHEN THE GLUCOSE LEVEL RISES TO ABOUT 3% BY WEIGHT OF THE TOTAL DEXTRINS, C. REMOVING ELECTROLYTES BY PASSING THE MIXTURE THROUGH A ION-EXCHANGE RESIN OR BY MAKING A SOLUTION OF THE MIXTURE IN WATER ADDING AN ALCOHOL TO FORM A DEXTRIN PRECIPITATE LEAVING THE ELECTROLYTE IN SOLUTION, DISSOLVING THE PRECIPITATE IN AQUEOUS ALCOHOL AND DISTILLING OF THE ALCOHOL, D. BOILING THE SOLUTION TO REDUCE PYROGENS, E. PASSING THE SOLUTION THROUGH A CANDLE OF SEITZ FILTER TO REMOVE BACTERIAL AND UNWANTED PROTEIN SUBSTANCES, F. REMOVING GLUCOSE BY DIALYSIS OR BY MEANS OF A DEXTRAN RESIN COLUMN, AND G. REMOVING THE LONG CHAIN DEXTRINS BY FRACTIONATION WITH ALCOHOL AND THEREAFTER RECOVERING GLUCOSE POLYMERS IN WHICH GLUCOSE UNITS IN THE POLYMER LINKED IN THE 1,6-POSITION CONSTITUTED NO MORE THAN 5% OF THE TOTAL LINKAGES.
Claim 3
Dependent Claim 18 words
Process as claimed in claim 1 in which the solution is concentrated before the removal of the glucose.
Claim 4
Dependent Claim 18 words
Process as claimed in claim 1 in which the solution is concentrated after the removal of the glucose.
Claim 5
Dependent Claim 32 words
Process as claimed in claim 1, in which any pyrogens remaining after step (g) are removed by treating the solution with activated charcoal or by passing the solution through an exchange resin.
Claim 6
Dependent Claim 23 words
Process as claimed in claim 1 in which the starch is free from water-soluble substances, heavy metal contaminants and any pest control substances.
Claim 7
Dependent Claim 22 words
Process as claimed in claim 1 in which the starch content of the solution to be hydrolysed is about 2.5% by weight.
Claim 8
Dependent Claim 20 words
Process as claimed in claim 1 in which the heating in step (b) is continued to induce maximum protein coagulation.
Claim 9
Dependent Claim 19 words
Process as claimed in claim 1 in which the ion-exchange resin of step (c) is a mixed bed resin.
Claim 10
Dependent Claim 15 words
Process as claimed in claim 1 in which the alcohol of step (c) is ethanol.
Claim 11
Dependent Claim 20 words
Process according to claim 1 in which between step (c) and step (d) the solution is treated with activated charcoal.
Claim 12
Dependent Claim 26 words
Process as claimed in claim 1 in which after step (g) the pH is adjusted to a value of from 6.8 to 7.2 followed by sterilisation.
Claim 13
Dependent Claim 23 words
Process as claimed in claim 1 in which the solution is filtered through a candle or Seitz filter before adjustment of the pH.
Claim 14
Dependent Claim 17 words
Process as claimed in claim 1 in which the starch of step (a) is replaced by amylose.

References Cited (Backward Citations)

US2891869A Cited
US3067098A Cited
US3788946A Cited
US3793461A Cited
US3756853A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1978-12-22 1979-06-23 1979-12-23 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1982-12-22 1983-06-23 1983-12-23 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1986-12-22 1987-06-23 1987-12-23 $7700.00 Window Closed / Lapsed

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