Carbenicillin analogues
Abstract
Abstract Carbenicillin analogues, non-toxic salts and hydrolyzable monoand di-esters useful in treating infectious diseases caused by Gram-positive and Gram-negative bacteria. The terminal side chain group R is a fully saturated heterocyclic or cycloalkyl radical. The heterocyclic radical has 5, 6 or 7 ring atoms and one or more heteroatoms including oxygen, sulphur, >SO2 or >NR'' wherein R'' is hydrogen, lower alkyl, aryl, aralkyl or aryloxycarbonyl. Cycloalkyl is exemplified by cyclopropyl, cyclopentyl, cyclohexyl or cycloheptyl. Representative penicillins are Alpha carboxycyclopropyl methyl penicillin, Alpha -carboxycyclohexyl methyl penicillin, Alpha -carboxy-2-tetrahydropyranyl methyl penicillin and Alpha -carboxytetrahydrothiophen-1,1-dioxide-3-yl methyl penicillin.
Inventors
- 👤 George Burton
- 👤 John Sydney Davies
- 👤 Ann Frances Hubbard
Bibliographic Details
Claims Analysis
Total Claims: 6References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
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