US3924622A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Zero-order release method
Assignee: Mead Johnson and Co LLC
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Filing: 1974-11-26
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Granted: 1975-12-09
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Expires: 1994-11-26
Abstract
Abstract A diffusible solid is released by diffusion into a fluid medium from a cavity within a container through an opening therein at a rate which is independent of the amount of solid present in the container. Zero-order release is effected by the shape of the cavity and the opening. The rate of release is related to the solubility and to the diffusion constant of the solid in the fluid medium. For a given substance, the rate of release is determined by cavity shape and dimensions of the diffusion opening. The method is adapted for use in both liquid and gaseous media and can be used for the zero-order release of drug substance into the system of a living organism, and for nonmedical uses.
Inventors
- 👤 Dana Brooke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 10:05
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61F; A61F6/00; A61F6/06; A61F6/14; A61J; A61J3/00; A61J3/08; A61K9/0002; A61K9/0004; A61M; A61M31/00; A61M31/002
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
287 words
Method for the automatic release at a desired substantially constant predetermined rate R of a diffusible solid into a fluid medium into which said solid has a propensity to diffuse wherein said solid has diffusion constant (D) and solubility (Cs) with respect to said medium which comprises 1. introducing said solid into a cavity within a container, said container being impervious to said solid and said medium during the period of delivery of said solid and having a slot-like port having uniform length and width and having two ends and two sides with the narrower dimension (a) at the ends and the longer dimension (L) at the sides, said port communicating in its entirety with said cavity, said cavity being defined by a rear wall, and a pair of parallel congruent planar end walls arranged at right angles to said slot and adjacent to the ends thereof, and a pair of inwardly extending congruent planar side walls adjacent the opposite sides of said slot and in substantially divergent radial relation to said slot and extending to said rear wall, said introduction being carried out so as to completely cover the rear wall of said cavity with said solid and seal said solid to the walls thereof, and expose a single surface thereof to the slot-like port in facing relation thereto for contact with said medium, and 2. immersing said container into said medium so that the medium enters the slot and contacts said exposed surface of said solid, and 3. adjusting the dimensions (a), (L), and ( Theta ), wherein ( Theta ) is the angle subtended by the side walls of said cavity, so that said rate R is achieved and is defined by the expression
Claim 2
Dependent Claim
287 words
Method for the automatic release at a desired substantially constant predetermined rate R of a diffusible solid into a fluid medium into which said solid has a propensity to diffuse wherein said solid has diffusion constant (D) and solubility (Cs) with respect to said medium which comprises 1. introducing said solid into a cavity within a container, said container being impervious to said solid and said medium during the period of delivery of said solid and having a slot-like port having uniform length and width and having two ends and two sides with the narrower dimension (a) at the ends and the longer dimension (L) at the sides, said port communicating in its entirety with said cavity, said cavity being defined by a rear wall, and a pair of parallel congruent planar end walls arranged at right angles to said slot and adjacent to the ends thereof, and a pair of inwardly extending congruent planar side walls adjacent the opposite sides of said slot and in substantially divergent radial relation to said slot and extending to said rear wall, said introduction being carried out so as to completely cover the rear wall of said cavity with said solid and seal said solid to the walls thereof, and expose a single surface thereof to the slot-like port in facing relation thereto for contact with said medium, and 2. immersing said container into said medium so that the medium enters the slot and contacts said exposed surface of said solid, and 3. adjusting the dimensions (a), (L), and ( Theta ), wherein ( Theta ) is the angle subtended by the side walls of said cavity, so that said rate R is achieved and is defined by the expression
Claim 3
Dependent Claim
22 words
immersing said container into said medium so that the medium enters the slot and contacts said exposed surface of said solid, and
Claim 4
Dependent Claim
22 words
immersing said container into said medium so that the medium enters the slot and contacts said exposed surface of said solid, and
Claim 5
Dependent Claim
22 words
The method of claim 1 wherein said solid is introduced into said container in the molten state and permitted to solidify therein.
Claim 6
Dependent Claim
39 words
The method of claim 1 wherein the exposed surface of said solid for contact with said medium is formed into an arcuate concave configuration defining a segment of a cylinder wall the axis of which lies within said slot.
Claim 7
Dependent Claim
37 words
adjusting the dimensions (a), (L), and ( Theta ), wherein ( Theta ) is the angle subtended by the side walls of said cavity, so that said rate R is achieved and is defined by the expression
Claim 8
Dependent Claim
37 words
adjusting the dimensions (a), (L), and ( Theta ), wherein ( Theta ) is the angle subtended by the side walls of said cavity, so that said rate R is achieved and is defined by the expression
Claim 9
Dependent Claim
100 words
The method of claim 1 wherein said solid is introduced into said container to form therein a uniform dispersion thereof in a solid matrix, said matrix being insoluble in said fluid medium and permeable to said solid, said matrix being characterized by diffusion constant (Dm) and partition coefficient (K) relative to said solid and said fluid medium, and suitably adjusting said angle ( Theta ), slot length (L), slot width (a), matrix diffusion constant (Dm), and matrix partition coefficient (K) to achieve the desired release rate (R) of the solid through the slot, said rate being defined by the expression
Claim 10
Dependent Claim
33 words
The method of claim 4 wherein prior to introduction said matrix is in the liquid state, said solid being dissolved or uniformly suspended therein and after said introduction the liquid matrix is solidified.
Claim 11
Dependent Claim
30 words
The method of claim 5 wherein said matrix prior to introduction is molten and said method is carried out at a temperature lower than the solidification temperature of said matrix.
Claim 12
Dependent Claim
12 words
The method of claim 6 wherein said matrix is white wax, USP.
Claim 13
Dependent Claim
20 words
The method of claim 5 wherein said liquid matrix is a polymerizable composition, and solidifiCation is accomplished by polymerization thereof.
Claim 14
Dependent Claim
14 words
The method of claim 8 wherein said polymerizable composition comprises a silicone rubber elastomer.
Claim 15
Dependent Claim
12 words
The method of claim 5 wherein said matrix is a thixotropic gel.
Claim 16
Dependent Claim
28 words
The method of claim 10 wherein said thixotropic gel is an aqueous composition containing a gelling agent selected from the group consisting of carboxypolymethylene, carboxymethylcellulose, and polyethylene glycol.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-08 | 1979-06-09 | 1979-12-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-08 | 1983-06-09 | 1983-12-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-08 | 1987-06-09 | 1987-12-09 | $7700.00 | Window Closed / Lapsed |