Patent US2816988A successfully refreshed from Google Patents.
US3923866A
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US
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Process for producing indan derivatives
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1973-06-19
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Granted: 1975-12-02
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Expires: 1993-06-19
Abstract
Abstract 5-Cyclohexylindan-1-carboxylic acid or esters thereof or amide thereof can be prepared starting from 5-cyclohexylindan-1-ol through replacing hydroxyl group at 1-position with halogen or organic sulfonyl group followed by replacing the halogen or organic sulfonyl group with nitril group, then hydrolysis or alcoholysis. The 5-cyclohexylindan-1-carboxylic acid or esters thereof or amide thereof can be obtained in its 6-halogenated derivative by the substitution of halogenation step at optional intermediate steps. The thus obtained compound is useful as anti-inflammatory agent, analgesics, antipyretics, antirheumatics and so on for either human and veterinary use.
Inventors
- 👤 Yoichi Sawa
- 👤 Toshinori Hattori
- 👤 Susumu Katsube
- 👤 Akitoshio Goto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 07:22
CPC Classifications
C; C07; C07C; C07C45/00; C07C45/45; C07C45/46; C07C17/00; C07C17/093; C07C17/16; C07C309/00; C07C45/61; C07C45/65
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
9 words
A PROCESS FOR PRODUCING A COMPOUND OF THE FORMULA:
Claim 2
Dependent Claim
9 words
A PROCESS FOR PRODUCING A COMPOUND OF THE FORMULA:
Claim 3
Dependent Claim
78 words
A process according to claim 1 wherein the aromatic sulfonylating agent is tosyl chloride, employed in a proportion of 1 to 2 moles per mole of compound II, the halogenating agent for compound III is chlorine, bromine or iodine, the proportion of halogenating agent being about 1 to 2 moles of halogen per mole of compound III and the alkali metal cyanide is employed in an amount of about 1 to 5 moles per mole of compound IV.
Claim 4
Dependent Claim
6 words
A process for the production of
Claim 5
Dependent Claim
6 words
A process for the production of
Claim 6
Dependent Claim
82 words
A process according to claim 3 wherein the halogenating agent for compound II is hydrogen halide or thionyl chloride, employed in a proportion of 1 to 2 moles per mole of compound II, the halogenating agent for compound III is chlorine, bromine or iodine, the proportion of halogenating agent being 1 to 2 moles of halogen per mole of compound III and the alkali metal cyanide is employed in an amount of about 1 to 5 moles per mole of compound IV.
References Cited (Backward Citations)
US3324174A
Cited
US3435075A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-01 | 1979-06-02 | 1979-12-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-01 | 1983-06-02 | 1983-12-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-01 | 1987-06-02 | 1987-12-02 | $7700.00 | Window Closed / Lapsed |