US3922259A
Expired / Lapsed
US
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Polymers of the Kunitz inhibitors, new medicaments containing these polymers and method for their manufacture
Assignee: Choay SA
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Filing: 1972-11-27
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Granted: 1975-11-25
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Expires: 1992-11-27
Abstract
Abstract Polymers or condensation products of the Kunitz inhibitor contain several Kunitz inhibitor molecules linked together, if necessary, by coupling groups such as those derived from glutaraldehyde. The products, especially the soluble polymers, having a molecular weight from about 12,000 to about 150,000, are valuable in the treatment of shock.
Inventors
- 👤 Edgar Sach
- 👤 Claude Raby
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 23:52
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/81; C07K14/8107; C07K14/811; C07K14/8114; A; A61; A61K; A61K31/00; A61K31/74; A61K31/785; A61K38/00
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
14 words
A DUNITZ INHIBITOR POLYMER WHICH HAS AT LEAST THE MOLECULAR WEIGHT OF A DIMER.
Claim 2
Dependent Claim
14 words
A DUNITZ INHIBITOR POLYMER WHICH HAS AT LEAST THE MOLECULAR WEIGHT OF A DIMER.
Claim 3
Dependent Claim
8 words
The soluble Kunitz inhibitor polymer of claim 1.
Claim 4
Dependent Claim
19 words
The polymer of claim 4 wherein the molecular weight of the polymer is from about 12,000 to about 150,000.
Claim 5
Dependent Claim
14 words
The polymer of claim 3 having a molecular weight from about 12,000 to 14,000.
Claim 6
Dependent Claim
12 words
The polymer of claim 3 having a molecular weight about 20, 000.
Claim 7
Dependent Claim
12 words
The polymer of claim 4 having a molecular weight about 65, 000.
Claim 8
Dependent Claim
30 words
Method for the preparation of a Kunitz inhibitor polymer, which comprises polymerizing by reacting a Kunitz inhibitor in a saline solution at ambient temperature, and separating the Kunitz inhibitor polymer.
Claim 9
Dependent Claim
30 words
Method for the preparation of a Kunitz inhibitor polymer, which comprises polymerizing by reacting a Kunitz inhibitor in a saline solution at ambient temperature, and separating the Kunitz inhibitor polymer.
Claim 10
Dependent Claim
16 words
Method according to claim 7, wherein the polymerization is carried out in the presence of glutaraldehyde.
Claim 11
Dependent Claim
26 words
Method aCcording to claim 8, wherein the polymerization is conducted in a buffer solution whose pH lies in the range from about 3 to about 7.
Claim 12
Dependent Claim
40 words
Method according to claim 9, wherein the reaction is carried out in a buffer solution whose pH lies in the range from about 3 to about 4 and the concentration of glutaraldehyde of the medium being between 0.1 and 5%.
Claim 13
Dependent Claim
18 words
Method according to claim 10, wherein the concentration of glutaraldhyde of the medium is between 0.1 and 1%.
Claim 14
Dependent Claim
23 words
Method according to claim 9, wherein the initial concentration of the Kunitz inhibitor in the medium is between about 1 and about 10%.
Claim 15
Dependent Claim
8 words
A soluble Kunitz inhibitor polymer having protein-coupled groups.
Claim 16
Dependent Claim
8 words
A soluble Kunitz inhibitor polymer having protein-coupled groups.
Claim 17
Dependent Claim
13 words
The Kunitz inhibitor polymer of claim 13 wherein the protein-coupled groups are glutaraldehyde-coupled.
Claim 18
Dependent Claim
13 words
The Kunitz inhibitor polymer of claim 2 which is soluble in physiological serum.
Claim 19
Dependent Claim
15 words
The Kunitz inhibitor polymer of claim 2 which is soluble in a solution of glucose.
Claim 20
Dependent Claim
8 words
A Kunitz inhibitor polymer which is a trimer.
Claim 21
Dependent Claim
8 words
A Kunitz inhibitor polymer which is a trimer.
Claim 22
Dependent Claim
8 words
A Kunitz inhibitor polymer which is a dimer.
Claim 23
Dependent Claim
8 words
A Kunitz inhibitor polymer which is a dimer.
Claim 24
Dependent Claim
9 words
An aquous solution of the polymer of claim 2.
Claim 25
Dependent Claim
11 words
The solution of the polymer of claim 19 which is buffered.
Claim 26
Dependent Claim
16 words
The solution of claim 20 which has a pH in the range of 3 to 4.
Claim 27
Dependent Claim
15 words
The process of claim 7 wherein the polymerization is carried out in a buffered solution.
Claim 28
Dependent Claim
16 words
The process of claim 7 wherein the polymerization is carried out at a pH above 7.
Claim 29
Dependent Claim
27 words
The process of claim 7 wherein a Kunitz inhibitor monomer is mixed with glutaraldhyde, the polymerization carried out, the polymer formed and separating the Kunitz inhibitor polymer.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-11-24 | 1979-05-26 | 1979-11-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-11-24 | 1983-05-26 | 1983-11-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-11-24 | 1987-05-26 | 1987-11-25 | $7700.00 | Window Closed / Lapsed |