US3920819A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nonaqueous vehicle for oral pharmaceutical suspensions
Assignee: Eli Lilly and Co
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Filing: 1974-12-02
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Granted: 1975-11-18
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Expires: 1994-12-02
Abstract
Abstract A nonaqueous vehicle for oral pharmaceutical suspensions is described which has a satisfactory taste, low toxicity, good flow properties and is highly resistant to settling and caking of the suspended material. Such a vehicle is comprised principally of refined fractionated coconut oil, hydrogenated castor oil, lecithin, aluminum stearate and an oil isoluble excipient such as sucrose. This nonaqueous vehicle is useful for preparing readyto-use oral pharmaceutical suspension of water degradable physiologically active agents.
Inventors
- 👤 Verlin C Stephens
- 👤 Kenneth S E Su
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 03:04
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/0095
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
69 words
A NONAQUEOUS VEHICLE FOR USE IN AN ORAL PHARMACEUTICAL SUSPENSION COMPRISED OF: (A) REFINED FRACTIONATED COCONUT OIL HAVING A SAPONIFICATION VALUE NOT LESS THAN 335 AND NOT MORE THAN 360, (HYDROGENATED CASTPR OR OIL HAVING AN IODINE NUMBER BELOW 6, (C) LECITHIN REFINED GRADE, (D) ALUMINUM STEARATE, AND (E) AN OIL INSOLUBLE EXCIPIENT OR COMBINATION EXCIPIENTS SELECTED FROM THE GROUP CONSISTING OF DEXTROSE, FRUCTOSE, GLUCOSE, MALTOSE, MANNITOL AND SUCROSE.
Claim 2
Dependent Claim
69 words
A NONAQUEOUS VEHICLE FOR USE IN AN ORAL PHARMACEUTICAL SUSPENSION COMPRISED OF: (A) REFINED FRACTIONATED COCONUT OIL HAVING A SAPONIFICATION VALUE NOT LESS THAN 335 AND NOT MORE THAN 360, (HYDROGENATED CASTPR OR OIL HAVING AN IODINE NUMBER BELOW 6, (C) LECITHIN REFINED GRADE, (D) ALUMINUM STEARATE, AND (E) AN OIL INSOLUBLE EXCIPIENT OR COMBINATION EXCIPIENTS SELECTED FROM THE GROUP CONSISTING OF DEXTROSE, FRUCTOSE, GLUCOSE, MALTOSE, MANNITOL AND SUCROSE.
Claim 3
Dependent Claim
12 words
The vehicle of claim 1 wherein said oil insoluble excipient is sucrose.
Claim 4
Dependent Claim
89 words
The vehicle of claim 1 wherein said vehicle is comprised of from about 0.7 to about 2.6 percent (W/V) of the aluminum stearate, from about 0.2 to about 0.8 percent (W/V) of the hydrogenated castor oil, from about 0.6 to 0.8 percent (W/V) of the lecithin refined grade, from about 24 to about 40 peRcent (W/V) of the oil insoluble excipient selected from the group consisting of dextrose, fructose, glucose, maltose, mannitol, sorbitol and sucrose, and from about 50 to about 85 percent (V/V) of refined fractionated coconut oil.
Claim 5
Dependent Claim
12 words
The vehicle of claim 3 wherein said oil insoluble excipient is sucrose.
Claim 6
Dependent Claim
70 words
A nonaqueous oral pharmaceutical suspension comprised of: (a) an oil insoluble physiologically active agent, (b) refined fractionated coconut oil having a saponification value of not less than 335 and not more than 360, (c) hydrogenated castor oil having an iodine number below 6, (d) lecithin refined grade, (e) aluminum stearate, and (f) an oil insoluble excipient selected from the group consisting of dextrose, fructose, glucose, maltose, mannitol, sorbitol and sucrose.
Claim 7
Dependent Claim
70 words
A nonaqueous oral pharmaceutical suspension comprised of: (a) an oil insoluble physiologically active agent, (b) refined fractionated coconut oil having a saponification value of not less than 335 and not more than 360, (c) hydrogenated castor oil having an iodine number below 6, (d) lecithin refined grade, (e) aluminum stearate, and (f) an oil insoluble excipient selected from the group consisting of dextrose, fructose, glucose, maltose, mannitol, sorbitol and sucrose.
Claim 8
Dependent Claim
15 words
The nonaqueous oral pharmaceutical suspension of claim 5 wherein said oil insoluble excipient is sucrose.
Claim 9
Dependent Claim
108 words
The nonaqueous oral pharmaceutical suspension of claim 6 comprised of (a) from about 2.5 to about 10.0 percent (W/V) of said physiologically active agent, (b) from about 0.7 to about 2.6 percent (W/V) of the aluminum stearate, (c) from about 0.2 to about 0.8 percent (W/V) of the hydrogenated castor oil, (d) from about 0.2 to about 0.8 percent (W/V) of the lecithin refined grade, (e) from about 28.0 to about 40.0 percent (W/V) of the oil insoluble excipient selected from the group consisting of dextrose, fructose, glucose, maltose, mannitol and sucrose, and (f) from about 50 to about 80 percent (V/V) of the refined fractionated coconut oil.
Claim 10
Dependent Claim
14 words
The nonaqueous pharmaceutical suspension of claim 7 wherein said oil insoluble excipient is sucrose.
Claim 11
Dependent Claim
15 words
The nonaqueous pharmaceutical suspension of claim 7 wherein said physiologically active agent is cephalexin monohydrate.
Claim 12
Dependent Claim
80 words
A nonaqueous oral pharmaceutical suspension comprised of: (a) about 5.5 percent (W/V) of cephalexin monohydrate, (b) about 1.0 percent (W/V) of aluminum stearate, (c) about 0.7 percent (W/V) of lecithin refined grade, (d) about 0.35 percent of castor oil hydrogenated having an iodine number of less than 6, (e) about 30.0 percent (W/V) of sucrose, and (f) about 74.0 percent (V/V) of refined fractionated coconut oil having a saponification value of not less than 335 and not more than 360.
Claim 13
Dependent Claim
80 words
A nonaqueous oral pharmaceutical suspension comprised of: (a) about 5.5 percent (W/V) of cephalexin monohydrate, (b) about 1.0 percent (W/V) of aluminum stearate, (c) about 0.7 percent (W/V) of lecithin refined grade, (d) about 0.35 percent of castor oil hydrogenated having an iodine number of less than 6, (e) about 30.0 percent (W/V) of sucrose, and (f) about 74.0 percent (V/V) of refined fractionated coconut oil having a saponification value of not less than 335 and not more than 360.
References Cited (Backward Citations)
US2867565A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-11-17 | 1979-05-19 | 1979-11-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-11-17 | 1983-05-19 | 1983-11-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-11-17 | 1987-05-19 | 1987-11-18 | $7700.00 | Window Closed / Lapsed |