US3920334A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dual purpose detector for a liquid chromatograph
Assignee: EIDP Inc
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Filing: 1973-11-13
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Granted: 1975-11-18
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Expires: 1993-11-13
Abstract
Abstract Disclosed herein is a detector, for use in a liquid chromatographic system, which permits the simultaneous measurement of the optical absorbance and fluorescence of the effluent from a liquid chromatographic column.
Inventors
- 👤 John Carl Steichen
- 👤 Jr Sydnor H Bryne
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 02:04
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/62; G01N21/63; G01N21/64; G01N21/645; G01N30/00; G01N30/02; G01N30/62; G01N30/74; G01N21/17; G01N2021/1734; G01N2021/1748; G01N2021/1751; G01N2021/6491; G01N21/84; G01N21/85
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
180 words
A detector to monitor the constituents of the effluent emerging from a liquid chromatographic column, comprising a. a longitudinal flow cell for the liquid emerging from the column, said flow cell having a longitudinal axis parallel to the path of liquid flow through the flow cell, at least one side wall with a portion transparent to fluorescent radiation, and end walls, each of which comprises a window; b. illuminating means disposed adjacent to a window at one end of said flow cell for passing a beam of radiation through said flow cell, said windows being transparent to the radiation emanating from said illuminating means; c. monitoring means disposed adjacent to the window at the other end of said flow cell for detecting changes in the intensity of the radiation emerging from said flow cell, said illuminating means and said monitoring means being located on the longitudinal axis of said flow cell; and d. fluorescence detector means, disposed relative to the transparent portion of the side wall of said flow cell for detecting fluorescent radiation emanating from within said flow cell.
Claim 2
Dependent Claim
180 words
A detector to monitor the constituents of the effluent emerging from a liquid chromatographic column, comprising a. a longitudinal flow cell for the liquid emerging from the column, said flow cell having a longitudinal axis parallel to the path of liquid flow through the flow cell, at least one side wall with a portion transparent to fluorescent radiation, and end walls, each of which comprises a window; b. illuminating means disposed adjacent to a window at one end of said flow cell for passing a beam of radiation through said flow cell, said windows being transparent to the radiation emanating from said illuminating means; c. monitoring means disposed adjacent to the window at the other end of said flow cell for detecting changes in the intensity of the radiation emerging from said flow cell, said illuminating means and said monitoring means being located on the longitudinal axis of said flow cell; and d. fluorescence detector means, disposed relative to the transparent portion of the side wall of said flow cell for detecting fluorescent radiation emanating from within said flow cell.
Claim 3
Dependent Claim
15 words
The liquid chromatographic system of claim 1 wherein said fluorescence detector means is a photomultiplier.
Claim 4
Dependent Claim
57 words
The liquid chromatographic system of claim 1 further comprising a reflective housing means to reflect light emanating from within said flow cell to said fluorescence detector means, said housing means being disposed relative to the transparent portions of the side wall of said flow cell to define in conjunction therewith a fluorescence chamber in said flow cell.
Claim 5
Dependent Claim
37 words
The liquid chromatographic system of claim 3 further comprising an emission filter located between said fluorescence detector means and said reflective housing means to prevent radiation emanating from said illuminating means from reaching said fluorescence detector means.
Claim 6
Dependent Claim
21 words
The liquid chromatographic system of claim 1 wherein said flow cell comprises a quartz tube and said windows are quartz windows.
Claim 7
Dependent Claim
42 words
The liquid chromatographic system of claim 5 further comprising flow rings disposed between said quartz tube and said quartz windows, each flow ring having a narrow orifice through which liquid is supplied to the flow cell and removed from the flow cell.
Claim 8
Dependent Claim
47 words
The liquid chromatographic system of claim 6 further comprising scatter-baffle means, disposed outside of and adjacent to the ends of said flow cell, to prevent any radiation scattered at the ends of said flow cell from entering the fluorescence chamber and producing a high fluorescence background signal.
References Cited (Backward Citations)
US3010798A
Cited
US3292484A
Cited
US3390605A
Cited
US3527538A
Cited
US3788744A
Cited
US3734620A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-11-17 | 1979-05-19 | 1979-11-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-11-17 | 1983-05-19 | 1983-11-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-11-17 | 1987-05-19 | 1987-11-18 | $7700.00 | Window Closed / Lapsed |