US3917704A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Alpha-aminoalkyl-4-hydroxy-3-alkylsulfonylmethylbenzyl alcohols
Assignee: GlaxoSmithKline LLC
•
Filing: 1973-05-10
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Granted: 1975-11-04
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Expires: 1993-05-10
Abstract
Abstract Alpha -Aminoalkyl-4-hydroxy-3-alkylsulfonylmethylbenzyl alcohols having Beta -adrenergic stimulant activity, particularly as selected bronchodilators, are prepared from 4hydroxyphenones by conversion to a 3-alkylsulfonylmethylphenone, bromination of these phenones and treatment of the resulting Alpha -bromo derivatives with an N-benzyl secondary amine, followed by catalytic hydrogenation to remove the benzyl groups and reduce the ketone moiety.
Inventors
- 👤 Carl Kaiser
- 👤 Stephen T Ross
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 20:23
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
6 words
A CHEMICAL COMPOUND OF THE FORMULA:
Claim 2
Dependent Claim
6 words
A CHEMICAL COMPOUND OF THE FORMULA:
Claim 3
Dependent Claim
12 words
A chemical compound according to claim 1 in which R is methyl.
Claim 4
Dependent Claim
12 words
A chemical compound according to claim 2 in which R2 is hydrogen.
Claim 5
Dependent Claim
13 words
A chemical compound according to claim 3, being the compound Alpha -(t-butylaminomethyl)-4-hydroxy-3-(methylsulfonylmethyl)benzyl alcohol.
Claim 6
Dependent Claim
13 words
A chemical compound according to claim 3, being the compound Alpha -(cyclopentylaminomethyl)-4-hydroxy-3-(methylsulfonylmethyl)benzyl alcohol.
Claim 7
Dependent Claim
16 words
A chemical compound according to claim 1 in which R is ethyl and R2 is hydrogen.
Claim 8
Dependent Claim
14 words
A chemical compound according to claim 2, being the compound 4-hydroxy- Alpha -isopropylaminomethyl-3-(methylsulfonylmethyl)-benzyl alcohol.
Claim 9
Dependent Claim
14 words
A chemical compound according to claim 2 in which R2 is methyl or ethyl.
Claim 10
Dependent Claim
13 words
A chemical compound according to claim 8, being the compound Alpha -(1-t-butylaminopropyl)-4-hydroxy-3-(methylsulfonylmethyl)-benzyl alcohol.
Claim 11
Dependent Claim
13 words
A chemical compound according to claim 8, beIng the compound Alpha -(1-t-butylaminoethyl)-4-hydroxy-3-(methylsulfonylmethyl)-benzyl alcohol.
Claim 12
Dependent Claim
14 words
A chemical compound according to claim 4 in the form of a hydrochloride salt.
References Cited (Backward Citations)
US3701808A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-11-03 | 1979-05-05 | 1979-11-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-11-03 | 1983-05-05 | 1983-11-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-11-03 | 1987-05-05 | 1987-11-04 | $7700.00 | Window Closed / Lapsed |