US3917608A
Expired / Lapsed
US
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Substituted 6,7 dihydro-1-oxo N(1H-tetrazol-5-yl)-1H,5H-benzo{8 ij{9 quinolizine carboxamides
Assignee: Allen and Hanburys Ltd
•
Filing: 1974-03-27
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Granted: 1975-11-04
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Expires: 1994-03-27
Abstract
Abstract Compounds of the general formula (I): and pharmaceutically acceptable salts thereof in which: R1 represents a hydrogen atom, an alkyl group, or the group OR3 where R3 is a hydrogen atom or an acyl group, or an alkenyl group or an alkyl group which alkyl group may optionally be substituted by amino, alkylamino, dialkylamino, alkylaralkylamino, aryl, aryloxy, acyloxy, alkoxy, hydroxy or tetrahydropyranyloxy groups; and up to 3 groups R1, which may be the same or different, are present; and R2 represents a hydrogen atom or an alkyl group. The compounds have utility for the treatment of conditions in which combination of an antigen with a reaginic anitbody is primarily responsible.
Inventors
- 👤 Gwynn Pennant Ellis
- 👤 Heulwen Moira Ridgway
- 👤 David Edmund Bays
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 09:54
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/04; C07D215/06; C07D455/00; C07D455/03; C07D455/04
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
5 words
COMPOUNDS OF THE FORMULA (I):
Claim 2
Dependent Claim
5 words
COMPOUNDS OF THE FORMULA (I):
Claim 3
Dependent Claim
36 words
Compounds as claimed in claim 1 in which R1 is selected from the group consisting of hydrogen, isopropyl, hydroxy, methoxy, ethoxy, isopropoxy, benzyloxy, allyloxy, 2-ethoxyethoxy, 2-hydroxyethoxy, 2-dimethylaminoethoxy, 2-methylbenzylaminoethoxy, trifluoroacetoxy, and 2-(tetrahydropyranyloxy)-ethoxy; R2 is hydrogen or methyl.
Claim 4
Dependent Claim
13 words
Compounds as claimed in claim 1 in which R2 represents hydrogen or alkyl.
Claim 5
Dependent Claim
11 words
A compound as claimed in claim 1 which is 6,7-dihydro-1-oxo-N(1H-tetrazol-5-yl)-1H,5H-benzo(ij) quinolizine-2-carboxamide.
Claim 6
Dependent Claim
11 words
A compound as claimed in claim 1 which is 6,7-dihydro-9-methoxy-1-oxo-N(1H-tetrazol-5yl)-1H,5H-benzo(ij)quinolizine-2 -carboxamide.
Claim 7
Dependent Claim
11 words
A compound as claimed in claim 1 which is 9-ethoxy-6,7-dihydro-1-oxo-N(1H-tetrazol-5-yl)-1H,5H-benzo(ij)quinolizine-2 -carboxamide.
Claim 8
Dependent Claim
11 words
A compound as claimed in claim 1 which is 9-(2-ethoxyethoxy)-6,7-dihydro-1-oxo-N(1H-tetrazol-5-yl)-1H,5H -benzo(ij)quinolizine-2-carboxamide.
Claim 9
Dependent Claim
10 words
A compound as claimed in claim 1 which is 6,7-dihydro-1-oxo-9-(2''-(2''''-tetrahydropyranyloxy)ethoxy)N(1H-tetrazol-5-yl)-1H,5H-benzo(ij)quinolizine-2-carboxamide.
Claim 10
Dependent Claim
11 words
A compound as claimed in claim 1 which is 6,7-dihydro-9-isopropoxy-1-oxo-N(1H-tetrazol-5-yl)-1H,5H -benzo(ij)quinolizine-2-carboxamide.
Claim 11
Dependent Claim
9 words
A compound in claim 1 which is 9-allyloxy-6,7-dihydro-1-oxo-N(1H-tetrazol-5-yl)-1H,5H-benzo(ij)quinolizine -2-carboxamide.
Claim 12
Dependent Claim
10 words
A compound as claimed in claim 1 which is 9-benzyloxy-6,7-dihydro-1-oxo-N(1H-tetrazol-5-yl)-1H,5H-benzo(ij)quinolizine-2-carboxamide.
Claim 13
Dependent Claim
13 words
A compound as claimed in claim 1 which is 9-(2-(N-benzyl-N-methylamino)ethoxy)-6,7-dihydro-1-oxo-N(1H-tetrazol-5-yl) -1H,5H-benzo(ij)quinolizine-2-carboxamide, hydrochloride, monohydrate.
Claim 14
Dependent Claim
11 words
A compound as claimed in claim 1 which is 6,7-dihydro-1-oxo-N(1H-tetrazol-5-yl)-9-(2''-(trifluoroacetoxy)ethoxy)-1H,5H -benzo(ij)quinolizine-2-carboxamide.
Claim 15
Dependent Claim
11 words
A compound as claimed in claim 1 which is 6,7-dihydro-9-(2-hydroxyethoxy)-1-oxo-N(1H-tetrazol-5-yl)-1H,5H -benzo(ij)quinolizine-2-carboxamide.
Claim 16
Dependent Claim
12 words
A compound as claimed in claim 1 which is 9-benzyloxy-6,7-dihydro-1-oxo-N(1H-tetrazol-5-yl)-1H,5H-benzo(ij)quinolizine-2-carboxamide, sodium salt.
Claim 17
Dependent Claim
11 words
A compound as claimed in claim 1 which is 6,7-dihydro-5-methyl-1-oxo-N(1H-tetrazol-5-yl)-1H,5H-benzo(ij)quinolizine-2 -carboxamide.
Claim 18
Dependent Claim
10 words
A compound as claimed in claim 1 which is 6,7-dihydro-9-isopropyl-1-oxo-N(1H-tetrazol-5-yl)-1H,5H-benzo(ij)quinolizine-2-carboxamide.
Claim 19
Dependent Claim
10 words
A compound as claimed in claim 1 which is 6,7-dihydro-9-hydroxy-1-oxo-N(1H-tetrazol-5-yl)-1H,5H-benzo(ij)quinolizine-2-carboxamide.
References Cited (Backward Citations)
US3728350A
Cited
US3793328A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-11-03 | 1979-05-05 | 1979-11-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-11-03 | 1983-05-05 | 1983-11-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-11-03 | 1987-05-05 | 1987-11-04 | $7700.00 | Window Closed / Lapsed |