US3915949A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Solid phase synthesis of ACTH
Assignee: Armour Pharmaceutical Co
•
Filing: 1974-02-12
•
Granted: 1975-10-28
•
Expires: 1994-02-12
Abstract
Abstract Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing R -CH2-Phe-Glu at one end of an amino acid chain, R being the resin and Phe and Glu being the residues of the amino acids phenylalanine and glutamic acid; and processes for the preparation of such resin peptides. Resin peptides are disclosed which contain amino acid chains identical with the amino acid chains of natural peptides having biological activity. Other resin peptides are disclosed which contain amino acid chains in which the amino acid residues differ in kind and sequence from amino acid chains of natural biologically active peptides but from which peptides having biological activity may be derived.
Inventors
- 👤 Robert L Colescott
- 👤 Emil Kaiser
- 👤 Charles D Bossinger
- 👤 Paul I Cook
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 18:10
CPC Classifications
C; C08; C08H; C08H1/00; A; A61; A61P; A61P5/00; A61P5/38; C07; C07K; C07K1/00; C07K1/04; C07K1/042; C07K14/00; C07K14/435; C07K14/665; C07K14/695; C08F; C08F8/00; C08F8/30; A61K; A61K38/00; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/28
Claims Analysis
Total Claims: 52
Claim 1
Independent Claim
5 words
A peptide having the structure:
Claim 2
Dependent Claim
5 words
A peptide having the structure:
Claim 3
Dependent Claim
5 words
A peptide having the structure:
Claim 4
Dependent Claim
5 words
A peptide having the structure:
Claim 5
Dependent Claim
6 words
A resin peptide having the structure:
Claim 6
Dependent Claim
6 words
A resin peptide having the structure:
Claim 7
Dependent Claim
6 words
A resin peptide having the structure:
Claim 8
Dependent Claim
6 words
A resin peptide having the structure:
Claim 9
Dependent Claim
6 words
A resin peptide having the structure:
Claim 10
Dependent Claim
6 words
A resin peptide having the structure:
Claim 11
Dependent Claim
6 words
A resin peptide having the structure:
Claim 12
Dependent Claim
6 words
A resin peptide having the structure:
Claim 13
Dependent Claim
6 words
A resin peptide having the structure:
Claim 14
Dependent Claim
6 words
A resin peptide having the structure:
Claim 15
Dependent Claim
6 words
A resin peptide having the structure:
Claim 16
Dependent Claim
6 words
A resin peptide having the structure:
Claim 17
Dependent Claim
6 words
A resin peptide having the structure:
Claim 18
Dependent Claim
6 words
A resin peptide having the structure:
Claim 19
Dependent Claim
6 words
A resin peptide having the structure:
Claim 20
Dependent Claim
6 words
A resin peptide having the structure:
Claim 21
Dependent Claim
17 words
In a process for synthesizing a resin peptide, the step of coupling NH2-Phe-CH2- R with the reactant
Claim 22
Dependent Claim
17 words
In a process for synthesizing a resin peptide, the step of coupling NH2-Phe-CH2- R with the reactant
Claim 23
Dependent Claim
24 words
The process of claim 11 including the additional step of contacting the reaction product of claim 11 with an acid to remove P therefrom.
Claim 24
Dependent Claim
11 words
The process of claim 11 including the additional step of coupling
Claim 25
Dependent Claim
27 words
The process of claim 13 including the additional step of contacting the reaction product of claim 13 with an acid to cleave P from said reaction product.
Claim 26
Dependent Claim
11 words
IN APROCESS FOR SYNTHESIZING A RESIN PEPTIDE, THE STEP OF COUPLING.
Claim 27
Dependent Claim
11 words
IN APROCESS FOR SYNTHESIZING A RESIN PEPTIDE, THE STEP OF COUPLING.
Claim 28
Dependent Claim
32 words
The process of claim 15 including the additional step of contacting the reaction product of claim 15 with anhydrous hydrogen fluoride to remove the R -CH2, Bz, T, Y and W groups.
Claim 29
Dependent Claim
33 words
The process of claim 16 in which V is trifluoracetyl and including the additional step of dissolving the reaction product of claim 16 in an aqueous base to remove the trifluoroacetyl protecting groups.
Claim 30
Dependent Claim
12 words
In a process for synthesizing a resin peptide, the step of coupling
Claim 31
Dependent Claim
12 words
In a process for synthesizing a resin peptide, the step of coupling
Claim 32
Dependent Claim
32 words
The process of claim 18 including the additional step of contacting the reaction product of claim 18 with anhydrous hydrogen fluoride to remove the R -CH2, BZ, T, Y and W groups.
Claim 33
Dependent Claim
33 words
The process of claim 19 in which V is trifluoroacetyl and including the additional step of contacting the reaction product of claim 19 with an aqueous base to remove the trifluoroacetyl protecting groups.
Claim 34
Dependent Claim
14 words
A resin peptide as set forth in claim 3 in which Bz is benzyl.
Claim 35
Dependent Claim
14 words
A resin peptide as set forth in claim 4 in which Bz is benzyl.
Claim 36
Dependent Claim
14 words
A resin peptide as set forth in claim 5 in which Bz is benzyl.
Claim 37
Dependent Claim
14 words
A resin peptide as set forth in claim 7 in which T is tosyl.
Claim 38
Dependent Claim
18 words
A resin peptide as set forth in claim 7 in which V is trifluoroacetyl and Bz is benzyl.
Claim 39
Dependent Claim
14 words
A resin peptide as set forth in claim 8 in which Bz is benzyl.
Claim 40
Dependent Claim
14 words
A resin peptide as set forth in claim 9 in which V is trifluoroacetyl.
Claim 41
Dependent Claim
14 words
A resin peptide as set forth in claim 10 in which V is trifluoracetyl.
Claim 42
Dependent Claim
14 words
A resin peptide as set forth in claim 10 in which T is tosyl.
Claim 43
Dependent Claim
18 words
A resin peptide as set forth in claim 10 in which V is trifluoracetyl and Bz is benzyl.
Claim 44
Dependent Claim
13 words
A process as set forth in claim 11 in which Bz is benzyl.
Claim 45
Dependent Claim
13 words
A process as set forth in claim 13 in which BZ is benzyl.
Claim 46
Dependent Claim
13 words
A process as set forth in claim 18 in which Bz is benzyl.
Claim 47
Dependent Claim
13 words
A process as set forth in claim 18 in which V is trifluoracetyl.
Claim 48
Dependent Claim
13 words
A process as set forth in claim 18 in which T is tosyl.
Claim 49
Dependent Claim
15 words
A process as set forth in claim 11 in which said diimide is dicyclohexyl carbodiimide.
Claim 50
Dependent Claim
15 words
A process as set forth in claim 13 in which said diimide is dicyclohexyl carbodiimide.
Claim 51
Dependent Claim
15 words
A process as set forth in claim 15 in which said diimide is dicyclohexyl carbodiimide.
Claim 52
Dependent Claim
15 words
A process as set forth in claim 18 in which said diimide is dicyclohexyl carbodiimide.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-10-27 | 1979-04-28 | 1979-10-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-10-27 | 1983-04-28 | 1983-10-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-10-27 | 1987-04-28 | 1987-10-28 | $7700.00 | Window Closed / Lapsed |