US3915652A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Means for transferring a liquid in a capillary open at both ends to an analyzing system
Assignee: Individual
•
Filing: 1974-12-16
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Granted: 1975-10-28
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Expires: 1994-12-16
Abstract
Abstract In a system for analyzing a fluid such as blood or blood plasma contained in capillaries, the capillaries, open at both ends, are filled with the fluid to be analyzed. These capillaries are carefully calibrated and serve as disposable pipets. The filled capillaries are disposed around a turntable or on a linear transport means and are brought to a work station. Fluid and air are pumped continuously by peristaltic action on flexible tubing through a by-pass tube. When a capillary is brought into position, connection is made with a fluid hose on both ends of the capillaries. Valve means is provided which closes the by-pass and opens the hose leading to the capillary. The fluid and air are now pumped through the capillary. After a predetermined time, the fluid hose leading to the capillary is closed and the capillary is removed. The valve in the by-pass system is now opened so that fluid now passes through the by-pass system. A second capillary is brought into place and the process is repeated until all the capillaries have been processed. The contents of the capillary are washed out, reagents are added, heating takes place if necessary, and finally the component being assayed is evaluated at a readout station.
Inventors
- 👤 Samuel Natelson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 11:59
CPC Classifications
G; G01; G01N; G01N35/00; G01N35/10; G01N35/1095; G01N35/1097; B; B01; B01L; B01L9/00; B01L9/06; B01L9/065; G01N2035/00178; G01N2035/00237; G01N2035/1027; G01N2035/1034; G01N2035/1039
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
75 words
AN ARRANGEMENT FOR INTRODUCING MINUTE QUANTITIES OF LIQIUDS INTO AN ANALYTICAL SYSTEM FOR ASSAY OF ITS COMPONENTS COMPRISING IN COMBINATION A. MOVING MEANS GOING ALONG A PREDETERMINED TRAVEL PATH TO A WORK STATION SAID MOVING MEANS HAVING THEREON A RETAINING BLOCK HORIZONTALLY BORED TO FORM CAPILLARIES OPEN AT BOTH ENDS IN SAID BLOCK, SO THAT A LIQUID SAMPLE MAY BE INSERTED INTO SAID CAPILLARY, B. MEANS FOR SEQUENTIALLY PRESENTING SAID CAPILLARIES TO SAID WORK STATION,
Claim 2
Dependent Claim
75 words
AN ARRANGEMENT FOR INTRODUCING MINUTE QUANTITIES OF LIQIUDS INTO AN ANALYTICAL SYSTEM FOR ASSAY OF ITS COMPONENTS COMPRISING IN COMBINATION A. MOVING MEANS GOING ALONG A PREDETERMINED TRAVEL PATH TO A WORK STATION SAID MOVING MEANS HAVING THEREON A RETAINING BLOCK HORIZONTALLY BORED TO FORM CAPILLARIES OPEN AT BOTH ENDS IN SAID BLOCK, SO THAT A LIQUID SAMPLE MAY BE INSERTED INTO SAID CAPILLARY, B. MEANS FOR SEQUENTIALLY PRESENTING SAID CAPILLARIES TO SAID WORK STATION,
Claim 3
Dependent Claim
92 words
An arrangement as claimed in claim 1, wherein said retaining block is bored for more than one capillary in vertical alignment and a corresponding number of sealing means operatively connected to said moving means and said work station for sequentially sealing the capillaries in vertical alignment simultaneously and linking them in a continuous flow system to separate inlet and outlet tubes so that the contents of each of said capillaries in vertical alignment may be transferred to each of separate analytical systems for multiple simultaneous analysis for various components in the samples.
Claim 4
Dependent Claim
94 words
An arrangement as claimed in claim 2 wherein said moving means is a rectangular rack having two flat outer walls and having therein resilient bed forms shaped and disposed to receive capillaries therein, first and second plates at said work station having connecting tubing terminating therein, said plates being disposed on both sides of said rack walls as the walls pass said work station so that said capillaries will be horizontally aligned with said tubing and spring means constantly biasing said plates against said walls to seal said inlets, outlets and wall against leakage.
Claim 5
Dependent Claim
58 words
An arrangement as claimed in claim 3 wherein said rack is a solid plastic rectangular rack and said plate is a solid flat plate disposed to engage said rack having thereon a plurality of nipples disposed to engage said inlets and outlets with spring means urging said nipples into contact with said inlets, outlets and said rack wall.
Claim 6
Dependent Claim
16 words
An arrangement as claimed in claim 1 including dispenser means operatively coupled to said inlet tube.
Claim 7
Dependent Claim
17 words
An arrangement as claimed in claim 1 including a peristaltic pump operatively coupled to said outlet tube.
Claim 8
Independent Claim
95 words
A method for introducing minute quantities of liquids into an analytical system comprising the steps of a. introducing said liquids to capillaries; b. disposing said capillaries in a horizontal row on moving means; c. moving said moving means along a travel path to a work station to sequentially present said capillaries while sealing said capillaries against leakage; d. ejecting said sample at said work station by coupling inlet and outlet tubes to the capillaries; and, e. permitting a wash solution to flow across said inlet, outlet tubes and capillaries to an analytical system for analysis.
Claim 9
Independent Claim
95 words
A method for introducing minute quantities of liquids into an analytical system comprising the steps of a. introducing said liquids to capillaries; b. disposing said capillaries in a horizontal row on moving means; c. moving said moving means along a travel path to a work station to sequentially present said capillaries while sealing said capillaries against leakage; d. ejecting said sample at said work station by coupling inlet and outlet tubes to the capillaries; and, e. permitting a wash solution to flow across said inlet, outlet tubes and capillaries to an analytical system for analysis.
Claim 10
Dependent Claim
20 words
A method as claimed in claim 7 wherein said capillaries arE disposed on a block which serves as moving means.
Claim 11
Dependent Claim
20 words
A method as claimed in claim 7 wherein said wash solution is squirted into the inlet tube by a syringe.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-10-27 | 1979-04-28 | 1979-10-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-10-27 | 1983-04-28 | 1983-10-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-10-27 | 1987-04-28 | 1987-10-28 | $7700.00 | Window Closed / Lapsed |