US3914254A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Basic esters of polyhydro-2-phenanthrylidene-acetic acids
Assignee: STWB Inc
•
Filing: 1969-11-25
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Granted: 1975-10-21
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Expires: 1989-11-25
Abstract
Abstract Alkyl polyhydro-2-phenanthrylideneacetates are prepared by interacting the corresponding 2-oxopolyhydrophenanthrenes with a tri-lower-alkyl Alpha -phosphono-lower-alkanoate. Said alkyl polyhydro-2-phenanthrylideneacetates are hydrolyzed to the free acid, and then reesterified via the acid chloride with a tertiaryamino-lower-alkanol to give basic esters having cardiotonic activity.
Inventors
- 👤 Philip E Shaw
- 👤 Sol J Daum
- 👤 Robert L Clarke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 20:13
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; C07C; C07C59/00; C07C59/40; C07C59/42; C07C59/46; C07C59/56; C07C59/58; C07C59/72; C07C59/76; C07C59/80; C07C59/82; C07C59/86; C07C59/90; C07D317/00; C07D317/08; C07D317/72; C07D339/00; C07D339/08; C07C2603/00; C07C2603/02; C07C2603/04; C07C2603/22; C07C2603/26
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
5 words
A COMPOUND OF THE FORMULA
Claim 2
Dependent Claim
5 words
A COMPOUND OF THE FORMULA
Claim 3
Dependent Claim
20 words
A compound according to claim 1, sub-paragraph (A) wherein R is di-lower-alkylamino-lower-alkyl, X is H2 and Z is O C.
Claim 4
Dependent Claim
19 words
A compound according to claim 1, sub-paragraph (A) wherein R is di-lower-alkylamino-lower-alkyl, X is H2 and Z is (HO)CH.
Claim 5
Dependent Claim
18 words
A compound according to claim 1, sub-paragraph (A) wherein R is di-lower-alkylamino-lower-alkyl, X is H2 and Z is
Claim 6
Dependent Claim
31 words
2-Dimethylaminoethyl 7,7-ethylenedisulfonyl-3,4,4a Alpha ,4b Beta ,5,6,7,8,8a Alpha ,9,10,10a Beta -dodecahydro- Delta 2(1H), -phenanthreneacetate, according to claim 4 where R is dimethylaminoethyl, R'', R'''' and R* are hydrogen and n is 2.
Claim 7
Dependent Claim
36 words
A compound selected from the group consisting of di-lower-alkylamino-lower-alkyl 3,4,4a Alpha ,4b,5,6,7,8,8a Alpha ,9,10, 10a Beta -dodecahydro-4b Beta ,8,8-trimethyl-7 Beta -hydroxy-Delta 2(1H), -phenanthreneacetate and di-lower-alkylamino-lower-alkyl 3,4,4a Alpha ,4b,5,6,7,-8,10,10a Beta -decahydro-4b Beta , 8,8-trimethyl-7-oxo- Delta 2(1H), -phenanthreneacetate.
Claim 8
Dependent Claim
36 words
A compound selected from the group consisting of di-lower-alkylamino-lower-alkyl 3,4,4a Alpha ,4b,5,6,7,8,8a Alpha ,9,10, 10a Beta -dodecahydro-4b Beta ,8,8-trimethyl-7 Beta -hydroxy-Delta 2(1H), -phenanthreneacetate and di-lower-alkylamino-lower-alkyl 3,4,4a Alpha ,4b,5,6,7,-8,10,10a Beta -decahydro-4b Beta , 8,8-trimethyl-7-oxo- Delta 2(1H), -phenanthreneacetate.
Claim 9
Dependent Claim
15 words
2-Dimethylaminoethyl 3,4,4a Alpha ,4b,5,6,7,8,10,10a Beta -decahydro-4b Beta ,8,8-trimethyl-7-oxo- Delta 2(1H), -phenanthreneacetate, according to claim 6.
Claim 10
Dependent Claim
14 words
A mixture of the two corresponding geometric isomers chosen from the compounds of formula:
Claim 11
Dependent Claim
14 words
A mixture of the two corresponding geometric isomers chosen from the compounds of formula:
Claim 12
Dependent Claim
20 words
A mixture according to claim 8, in which the geometric isomers thereof are 3-hydroxy-4,4,14-desmethyl-cassenic and -isocassenic acid Beta -dimethyl-aminoethyl ester.
Claim 13
Dependent Claim
20 words
A mixture according to claim 8, in which the geometric isomers thereof are 3-hydroxy-4,4-desmethyl-14-epicassenic and -isocassenic acid Beta -dimethyl-aminoethyl ester.
References Cited (Backward Citations)
US3553251A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-10-20 | 1979-04-21 | 1979-10-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-10-20 | 1983-04-21 | 1983-10-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-10-20 | 1987-04-21 | 1987-10-21 | $7700.00 | Window Closed / Lapsed |