US3912748A
Expired / Lapsed
US
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Benzoxazole derivatives
Assignee: Lilly Industries Ltd
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Filing: 1973-05-01
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Granted: 1975-10-14
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Expires: 1993-05-01
Abstract
Abstract The invention provides novel 5- and 6-benzoxazolyl alkanoic acids, optionally substituted in the 2-position, and derivatives thereof which possess anti-inflammatory, anti-pyretic and analgesic activity. Also provided is a process for preparing such compounds by cyclising an appropriately substituted o-aminophenol and, if necessary, converting the resultant benzoxazole to the desired compound.
Inventors
- 👤 Delme Evans
- 👤 David William Dunwell
- 👤 Terence Alan Hicks
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 04:36
CPC Classifications
C; C07; C07D; C07D263/00; C07D263/52; C07D263/54; C07D263/56; A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/34; A61K31/38; A61K31/395; A61K31/435; A61K31/44; A61K31/495; A61P; A61P25/00; A61P25/04; A61P29/00; C07C; C07C255/00; C07D263/57; C07D263/58
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
4 words
COMPOUND OF THE FORMULA:
Claim 2
Dependent Claim
4 words
COMPOUND OF THE FORMULA:
Claim 3
Dependent Claim
41 words
Compound according to claim 1, wherein R1 is hydrogen, R2 is methyl, R3 is -COOR5, where R5 is C1-4 alkyl; or -COOH or an alkali or alkaline earth metal, aluminum or ammonium salt thereof, and R4 is phenyl, monohalogenophenyl or dihalogenophenyl.
Claim 4
Dependent Claim
56 words
A compound according to claim 1 in which R1 is H, R2 is H or CH3, R3 is COOH or CONH2, the group CR1R2R3 is in the 5 position of the benzoxazole nucleus and R4 is pyridyl phenyl or phenyl substituted by one or two groups selected from halogen, methyl, methoxy, acetyl, methylsulphonyl, nitro or hydroxy.
Claim 5
Dependent Claim
31 words
Compound according to claim 1, wherein R1 is hydrogen, R2 is methyl and R4 is phenyl optionally substituted by one or two substituents selected from halogen, methyl, methoxy, nitro or hydroxy.
Claim 6
Dependent Claim
13 words
Compound accordIng to claim 2 wherein said compound is 2-(2-p-chlorophenyl-5- or 6-benzoxazolyl)propionic acid.
Claim 7
Dependent Claim
13 words
Compound according to claim 2, wherein said compound is 2-(2-p-fluorophenyl-5- or 6-benzoxazolyl)propionic acid.
Claim 8
Dependent Claim
13 words
Compound according to claim 2, wherein said compound is 2-(2-(2,4-dichlorophenyl)-5- or 6-benzoxazoly)propionic acid.
References Cited (Backward Citations)
US3136773A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-10-13 | 1979-04-14 | 1979-10-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-10-13 | 1983-04-14 | 1983-10-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-10-13 | 1987-04-14 | 1987-10-14 | $7700.00 | Window Closed / Lapsed |