US3904593A
Expired / Lapsed
US
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Peptide derivatives having an ' -hydrazide linkage and preparation thereof
Assignee: Wyeth LLC
•
Filing: 1973-02-07
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Granted: 1975-09-09
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Expires: 1993-02-07
Abstract
Abstract Peptide derivatives having an Alpha -hydrazide linkage and methods for their preparation are disclosed. The derivatives are embodied by the hexapeptide derivatives H-Ala-PheN(N(R1)(R2))CHR3CO-Gly-Leu-Met-NH2 and H-Ala-Phe-Val-GlyN(N(R1)(R2))CHR3CONHCH(CH2CH23)CONH2 in which R1 and R2 are each lower alkyl and R3 is an amino acid side chain. The hexapeptide derivatives possess hypotensive activity and methods for their use are given.
Inventors
- 👤 Hans U Immer
- 👤 Verner R Nelson
- 👤 Manfred K Gotz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 17:55
CPC Classifications
C; C07; C07C; C07C243/00; C07K; C07K7/00; C07K7/04; C07K7/22; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
5 words
A COMPOUND OF FORMULA 1
Claim 2
Dependent Claim
5 words
A COMPOUND OF FORMULA 1
Claim 3
Dependent Claim
6 words
A compund of the formula 1
Claim 4
Dependent Claim
6 words
A compund of the formula 1
Claim 5
Dependent Claim
17 words
A pharmaceutically acceptable acid addition salt of the compound of formula 1 as claimed in claim 1.
Claim 6
Dependent Claim
15 words
The corresponding t-butoxycarbonyl derivative of the compound of formula 1 as claimed in claim 1.
Claim 7
Dependent Claim
1 words
Alanylphenylalanyl(N-(dimethylamino)-DL-valyl)-glycylleucylmethioninamide.
Claim 8
Dependent Claim
1 words
Alanylphenylalanyl(N-(dimethylamino)-DL-valyl)-glycylleucylmethioninamide.
Claim 9
Dependent Claim
1 words
Alanylphenylalanylvalylglycyl(N-(dimethylamino)DL-leucyl)-DL-methioninamide.
Claim 10
Dependent Claim
1 words
Alanylphenylalanylvalylglycyl(N-(dimethylamino)DL-leucyl)-DL-methioninamide.
Claim 11
Dependent Claim
2 words
N-(t-Butoxycarbonyl)alanylphenylalanyl(N-(dimethylamino)-DL -valyl)glycylleucylmethioninamide.
Claim 12
Dependent Claim
2 words
N-(t-Butoxycarbonyl)alanylphenylalanyl(N-(dimethylamino)-DL -valyl)glycylleucylmethioninamide.
Claim 13
Dependent Claim
2 words
N-(t-Butoxycarbonyl)alanylphenylalanylvalylglycyl(N-(dimethylamino)-DL -leucyl)-DL-methioninamide.
Claim 14
Dependent Claim
2 words
N-(t-Butoxycarbonyl)alanylphenylalanylvalylglycyl(N-(dimethylamino)-DL -leucyl)-DL-methioninamide.
Claim 15
Dependent Claim
6 words
A compound of the formula 2
Claim 16
Dependent Claim
6 words
A compound of the formula 2
Claim 17
Dependent Claim
3 words
N-(t-Butoxycarbonyl)phenylalanyl(N-(dimethylamino)-DL-valyl)glycine ethyl ester.
Claim 18
Dependent Claim
3 words
N-(t-Butoxycarbonyl)phenylalanyl(N-(dimethylamino)-DL-valyl)glycine ethyl ester.
Claim 19
Dependent Claim
3 words
N-(t-Butoxycarbonyl)glycyl(N-(dimethylamino)-DLleucyl)-DL-methionine ethyl ester.
Claim 20
Dependent Claim
3 words
N-(t-Butoxycarbonyl)glycyl(N-(dimethylamino)-DLleucyl)-DL-methionine ethyl ester.
Claim 21
Dependent Claim
2 words
N-(t-Butoxycarbonyl)phenylalanyl(N-(dimethylamino)-DL -valyl)glycylleucylmethioninamide.
Claim 22
Dependent Claim
2 words
N-(t-Butoxycarbonyl)phenylalanyl(N-(dimethylamino)-DL -valyl)glycylleucylmethioninamide.
Claim 23
Dependent Claim
1 words
N-(t-Butoxycarbonyl)glycyl(N-(dimethylamino)-DL-leucyl)-DL-methioninamide.
Claim 24
Dependent Claim
1 words
N-(t-Butoxycarbonyl)glycyl(N-(dimethylamino)-DL-leucyl)-DL-methioninamide.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-09-08 | 1979-03-10 | 1979-09-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-09-08 | 1983-03-10 | 1983-09-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-09-08 | 1987-03-10 | 1987-09-09 | $7700.00 | Window Closed / Lapsed |